hexadecylphosphocholine

Independent reference data for hexadecylphosphocholine (CAS 58066-85-6), compiled from public chemistry databases.

Registry identifiers across databases

Computed descriptors

Physicochemical values on record

Documented uses on record

For the treatment of mucosal (caused by Leishmania braziliensis), cutaneous (caused by L. braziliensis, L. guyanensis, and L. panamensis), and visceral leishmaniasis (caused by L. donovani). In comparing Leishmania drug susceptibility, it has been found that L. donovani is the most susceptible to miltefosine while L. major is the least susceptible. Off-label use includes treatment of free-living amebae (FLA) infections (unlabeled use; CDC, 2013).Miltefosine is an orally available, alkyl phospholipid that is used in the treatment of both cutaneous and visceral leishmaniasis. Miltefosine therapy is often accompanied by transient mild-to-moderate serum aminotransferase elevations during the first 1 or 2 weeks of treatment, but has not been implicated in cases of clinically apparent liver injury with jaundice.

Synonyms and trade names

Miltefosine; 58066-85-6; Hexadecylphosphocholine; Impavido; Miltex; HDPC; Hexadecylphosphorylcholine; Miltefosina; Miltefosinum; n-Hexadecylphosphorylcholine; hexadecyl 2-(trimethylazaniumyl)ethyl phosphate; D-18506; miltefosin; 53EY29W7EC; NSC-605583; DTXSID7045942

GHS hazard classification

Reported hazard statements	H301 (100%), H319 (11.4%), H334 (84.8%), H361 (12.7%), H372 (11.4%)

H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]

H319 (11.4%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]

What the public record says

hexadecylphosphocholine · CAS 58066-85-6 · C21H46NO4P. UNII 53EY29W7EC. Dissociation Constants: ~2.

Physical description and handling notes

Source: PubChem / Wikidata; the batch COA governs where values differ.