CLONIDINE (CAS 4205-90-7) — formula C9H9Cl2N3, molecular weight 230.09; category organic chemicals.
| CAS Number | 4205-90-7 |
|---|---|
| Molecular Formula | C9H9Cl2N3 |
| Molecular Weight | 230.09 |
| Melting Point | 130 |
| LogP | 1.59 |
| Applications | Uses: MEDICATION, Use (kg, approx.) in Germany (2009): >10, Use (kg) in USA (2002): 69, Consumption (g per capita, approx.) in Germany (2009): 0.000122, Consumption (g per capita) in the USA (2002): 0.000245, Calculated removal (%): 9, May be used as an adjunct in the treatment of hypertension, as an epidural infusion as an adjunct treatment in the management of severe cancer pain that is not relieved by opiate analgesics alone, for differential diagnosis of pheochromocytoma in hypertensive patients, prophylaxis of vascular migraine headaches, treatment of severe dysmenorrhea, management of vasomotor symptoms associated with menopause, rapid detoxification in the management of opiate withdrawal, treatment of alcohol withdrawal used in conjunction with benzodiazepines, management of nicotine dependence, topical use to reduce intraocular pressure in the treatment of open-angle and secondary glaucoma and hemorrhagic glaucoma associated with hypertension, and in the treatment of attention-deficit hyperactivity disorder (ADHD)., Use Classification: Pharmaceuticals, Methods of Manufacturing: Ammonium thiocyanate converts 2, 6-dichloroaniline to the thiourea, which is treated with methyl iodide to yield the S-methylthiouronium salt. The latter compound, with ethylenediamine, closes the imidazoline ring to afford the product., Clonidine hydrochloride, Zeile et al, US patent 3, 202, 660 (1965 to Boehringer Ing). ... In shaving soap formulations, 190, 802 (1965 to Boehringer Ing)., Formulations, Preparations: Table: Clonidine hydrochloride Preparations [Table#4364], Table: Clonidine Preparations [Table#4365] |
| Category | Organic Chemicals |
Documented applications: Uses: MEDICATION, Use (kg, approx.) in Germany (2009): >10, Use (kg) in USA (2002): 69, Consumption (g per capita, approx.) in Germany (2009): 0.000122, Consumption (g per capita) in the USA (2002): 0.000245, Calculated removal (%): 9, May be used as an adjunct in the treatment of hypertension, as an epidural infusion as an adjunct treatment in the management of severe cancer pain that is not relieved by opiate analgesics alone, for differential diagnosis of pheochromocytoma in hypertensive patients, prophylaxis of vascular migraine headaches, treatment of severe dysmenorrhea, management of vasomotor symptoms associated with menopause, rapid detoxification in the management of opiate withdrawal, treatment of alcohol withdrawal used in conjunction with benzodiazepines, management of nicotine dependence, topical use to reduce intraocular pressure in the treatment of open-angle and secondary glaucoma and hemorrhagic glaucoma associated with hypertension, and in the treatment of attention-deficit hyperactivity disorder (ADHD)., Use Classification: Pharmaceuticals, Methods of Manufacturing: Ammonium thiocyanate converts 2, 6-dichloroaniline to the thiourea, which is treated with methyl iodide to yield the S-methylthiouronium salt. The latter compound, with ethylenediamine, closes the imidazoline ring to afford the product., Clonidine hydrochloride, Zeile et al, US patent 3, 202, 660 (1965 to Boehringer Ing). ... In shaving soap formulations, 190, 802 (1965 to Boehringer Ing)., Formulations, Preparations: Table: Clonidine hydrochloride Preparations [Table#4364], Table: Clonidine Preparations [Table#4365].
CLONIDINE is a carbon-based organic compound with CAS registry number 4205-90-7 and molecular formula C9H9Cl2N3 (molecular weight 230.09), belonging to the organic chemicals segment of chemical raw materials.
CAS number: 4205-90-7
Its molecular formula C9H9Cl2N3 comprises 9 C, 9 H, 2 Cl, 3 N atoms.
Also known as: CLONIDINE · 可乐定
Category: organic chemicals
The CAS registry number of CLONIDINE is 4205-90-7.
Molecular formula C9H9Cl2N3, molecular weight 230.09.
It is also registered under: CLONIDINE, 可乐定.
Recorded applications: Uses: MEDICATION, Use (kg, approx.) in Germany (2009): >10, Use (kg) in USA (2002): 69, Consumption (g per capita, approx.) in Germany (2009): 0.000122, Consumption (g per capita) in the USA (2002): 0.000245, Calculated removal (%): 9, May be used as an adjunct in the treatment of hypertension, as an epidural infusion as an adjunct treatment in the management of severe cancer pain that is not relieved by opiate analgesics alone, for differential diagnosis of pheochromocytoma in hypertensive patients, prophylaxis of vascular migraine headaches, treatment of severe dysmenorrhea, management of vasomotor symptoms associated with menopause, rapid detoxification in the management of opiate withdrawal, treatment of alcohol withdrawal used in conjunction with benzodiazepines, management of nicotine dependence, topical use to reduce intraocular pressure in the treatment of open-angle and secondary glaucoma and hemorrhagic glaucoma associated with hypertension, and in the treatment of attention-deficit hyperactivity disorder (ADHD)., Use Classification: Pharmaceuticals, Methods of Manufacturing: Ammonium thiocyanate converts 2, 6-dichloroaniline to the thiourea, which is treated with methyl iodide to yield the S-methylthiouronium salt. The latter compound, with ethylenediamine, closes the imidazoline ring to afford the product., Clonidine hydrochloride, Zeile et al, US patent 3, 202, 660 (1965 to Boehringer Ing). ... In shaving soap formulations, 190, 802 (1965 to Boehringer Ing)., Formulations, Preparations: Table: Clonidine hydrochloride Preparations [Table#4364], Table: Clonidine Preparations [Table#4365].
Category: Organic Chemicals.
Independent reference data for CLONIDINE (CAS 4205-90-7), compiled from public chemistry databases.
| CAS 号 | 4205-90-7 |
|---|---|
| PubChem CID | 2803 |
| 分子式 | C9H9Cl2N3 |
| IUPAC 名称 | N-(2,6-dichlorophenyl)-4,5-dihydro-1H-imidazol-2-amine |
| UNII（FDA） | MN3L5RMN02 |
| Molecular Weight | 230.09 |
|---|---|
| XLogP3 | 1.6 |
| Hydrogen Bond Donor Count | 2 |
| Hydrogen Bond Acceptor Count | 1 |
| Rotatable Bond Count | 2 |
| Exact Mass | 229.0173527 |
| Monoisotopic Mass | 229.0173527 |
| Topological Polar Surface Area | 36.4 |
| Heavy Atom Count | 14 |
| Melting Point | 130 |
|---|---|
| Melting Point | 130 °C |
| Solubility | 4.80e-01 g/L |
| LogP | 1.59 |
| LogP | log Kow = 1.57 |
| LogP | 2.7 |
| Dissociation Constants | 8.05 (at 25 °C) |
| Dissociation Constants | pKa = 8.05 |
clonidine; 4205-90-7; Clonidin; N-(2,6-Dichlorophenyl)-4,5-dihydro-1H-imidazol-2-amine; Chlornidinum; Catapres-TTS; ST-155-BS; Catapresan; Catapressan; Clonidina; ST 155BS; CATAPRES-TTS-1; CATAPRES-TTS-2; CATAPRES-TTS-3; Clonidinum; Catarpres-TTS
| 已通报的危害声明 | H301 (100%), H310 (55.8%), H330 (56.8%) |
|---|
可乐定 · CAS 4205-90-7 · C9H9Cl2N3. UNII MN3L5RMN02. Melting Point: 130; Melting Point: 130 °C; Solubility: 4.80e-01 g/L.
Source: PubChem / Wikidata; the batch COA governs where values differ.
Supplier: Jinan Shenghe Chemical Co., Ltd.
中文页面: 可乐定