可乐定（CAS 4205-90-7）：分子式 C9H9Cl2N3、分子量 230.09。
| CAS号 | 4205-90-7 |
|---|---|
| 分子式 | C9H9Cl2N3 |
| 分子量 | 230.09 |
| 熔点 | 130 |
| LogP | 1.59 |
| 应用领域 | Uses: MEDICATION、Use (kg、approx.) in Germany (2009): >10、Use (kg) in USA (2002): 69、Consumption (g per capita、approx.) in Germany (2009): 0.000122、Consumption (g per capita) in the USA (2002): 0.000245、Calculated removal (%): 9、May be used as an adjunct in the treatment of hypertension、as an epidural infusion as an adjunct treatment in the management of severe cancer pain that is not relieved by opiate analgesics alone、for differential diagnosis of pheochromocytoma in hypertensive patients、prophylaxis of vascular migraine headaches、treatment of severe dysmenorrhea、management of vasomotor symptoms associated with menopause、rapid detoxification in the management of opiate withdrawal、treatment of alcohol withdrawal used in conjunction with benzodiazepines、management of nicotine dependence、topical use to reduce intraocular pressure in the treatment of open-angle and secondary glaucoma and hemorrhagic glaucoma associated with hypertension、and in the treatment of attention-deficit hyperactivity disorder (ADHD).、Use Classification: Pharmaceuticals、Methods of Manufacturing: Ammonium thiocyanate converts 2、6-dichloroaniline to the thiourea、which is treated with methyl iodide to yield the S-methylthiouronium salt. The latter compound、with ethylenediamine、closes the imidazoline ring to afford the product.、Clonidine hydrochloride、Zeile et al、US patent 3、202、660 (1965 to Boehringer Ing). ... In shaving soap formulations、190、802 (1965 to Boehringer Ing).、Formulations、Preparations: Table: Clonidine hydrochloride Preparations [Table#4364]、Table: Clonidine Preparations [Table#4365] |
登记用途：Uses: MEDICATION、Use (kg、approx.) in Germany (2009): >10、Use (kg) in USA (2002): 69、Consumption (g per capita、approx.) in Germany (2009): 0.000122、Consumption (g per capita) in the USA (2002): 0.000245、Calculated removal (%): 9、May be used as an adjunct in the treatment of hypertension、as an epidural infusion as an adjunct treatment in the management of severe cancer pain that is not relieved by opiate analgesics alone、for differential diagnosis of pheochromocytoma in hypertensive patients、prophylaxis of vascular migraine headaches、treatment of severe dysmenorrhea、management of vasomotor symptoms associated with menopause、rapid detoxification in the management of opiate withdrawal、treatment of alcohol withdrawal used in conjunction with benzodiazepines、management of nicotine dependence、topical use to reduce intraocular pressure in the treatment of open-angle and secondary glaucoma and hemorrhagic glaucoma associated with hypertension、and in the treatment of attention-deficit hyperactivity disorder (ADHD).、Use Classification: Pharmaceuticals、Methods of Manufacturing: Ammonium thiocyanate converts 2、6-dichloroaniline to the thiourea、which is treated with methyl iodide to yield the S-methylthiouronium salt. The latter compound、with ethylenediamine、closes the imidazoline ring to afford the product.、Clonidine hydrochloride、Zeile et al、US patent 3、202、660 (1965 to Boehringer Ing). ... In shaving soap formulations、190、802 (1965 to Boehringer Ing).、Formulations、Preparations: Table: Clonidine hydrochloride Preparations [Table#4364]、Table: Clonidine Preparations [Table#4365]。
可乐定 是一种化工化合物，登记 CAS 号为 4205-90-7，分子式 C9H9Cl2N3（分子量 230.09）。
登记 CAS 号：4205-90-7
其分子式 C9H9Cl2N3 由 9 个碳、9 个氢、2 个氯、3 个氮 组成。
别名/同义词：可乐定 · CLONIDINE
可乐定 的 CAS 登记号为 4205-90-7。
分子式 C9H9Cl2N3，分子量 230.09。
别名/同义词：可乐定、CLONIDINE。
登记用途：Uses: MEDICATION、Use (kg、approx.) in Germany (2009): >10、Use (kg) in USA (2002): 69、Consumption (g per capita、approx.) in Germany (2009): 0.000122、Consumption (g per capita) in the USA (2002): 0.000245、Calculated removal (%): 9、May be used as an adjunct in the treatment of hypertension、as an epidural infusion as an adjunct treatment in the management of severe cancer pain that is not relieved by opiate analgesics alone、for differential diagnosis of pheochromocytoma in hypertensive patients、prophylaxis of vascular migraine headaches、treatment of severe dysmenorrhea、management of vasomotor symptoms associated with menopause、rapid detoxification in the management of opiate withdrawal、treatment of alcohol withdrawal used in conjunction with benzodiazepines、management of nicotine dependence、topical use to reduce intraocular pressure in the treatment of open-angle and secondary glaucoma and hemorrhagic glaucoma associated with hypertension、and in the treatment of attention-deficit hyperactivity disorder (ADHD).、Use Classification: Pharmaceuticals、Methods of Manufacturing: Ammonium thiocyanate converts 2、6-dichloroaniline to the thiourea、which is treated with methyl iodide to yield the S-methylthiouronium salt. The latter compound、with ethylenediamine、closes the imidazoline ring to afford the product.、Clonidine hydrochloride、Zeile et al、US patent 3、202、660 (1965 to Boehringer Ing). ... In shaving soap formulations、190、802 (1965 to Boehringer Ing).、Formulations、Preparations: Table: Clonidine hydrochloride Preparations [Table#4364]、Table: Clonidine Preparations [Table#4365]。
可乐定（CAS 4205-90-7）的独立参考数据，整理自公开化学数据库。
| CAS 号 | 4205-90-7 |
|---|---|
| PubChem CID | 2803 |
| 分子式 | C9H9Cl2N3 |
| IUPAC 名称 | N-(2,6-dichlorophenyl)-4,5-dihydro-1H-imidazol-2-amine |
| UNII（FDA） | MN3L5RMN02 |
| Molecular Weight | 230.09 |
|---|---|
| XLogP3 | 1.6 |
| Hydrogen Bond Donor Count | 2 |
| Hydrogen Bond Acceptor Count | 1 |
| Rotatable Bond Count | 2 |
| Exact Mass | 229.0173527 |
| Monoisotopic Mass | 229.0173527 |
| Topological Polar Surface Area | 36.4 |
| Heavy Atom Count | 14 |
| Melting Point | 130 |
|---|---|
| Melting Point | 130 °C |
| Solubility | 4.80e-01 g/L |
| LogP | 1.59 |
| LogP | log Kow = 1.57 |
| LogP | 2.7 |
| Dissociation Constants | 8.05 (at 25 °C) |
| Dissociation Constants | pKa = 8.05 |
clonidine; 4205-90-7; Clonidin; N-(2,6-Dichlorophenyl)-4,5-dihydro-1H-imidazol-2-amine; Chlornidinum; Catapres-TTS; ST-155-BS; Catapresan; Catapressan; Clonidina; ST 155BS; CATAPRES-TTS-1; CATAPRES-TTS-2; CATAPRES-TTS-3; Clonidinum; Catarpres-TTS
| 已通报的危害声明 | H301 (100%), H310 (55.8%), H330 (56.8%) |
|---|
可乐定 · CAS 4205-90-7 · C9H9Cl2N3. UNII MN3L5RMN02. Melting Point: 130; Melting Point: 130 °C; Solubility: 4.80e-01 g/L.
数据来源：PubChem / Wikidata；与随货 COA 不一致时以 COA 为准。
English page: CLONIDINE