RUBRATOXINA (CAS 22467-31-8) — formula C26H32O11, molecular weight 520.5; category organic chemicals.
| CAS Number | 22467-31-8 |
|---|---|
| Molecular Formula | C26H32O11 |
| Molecular Weight | 520.5 |
| Melting Point | 210-214 °C (dec.) |
| LogP | 1.4 |
| Applications | Uses: Hepatotoxic metabolite from the molds Penicillium rubrum and P. purpurogenum, Often found growing in feedstuffs with Aspergillus sp., May coexist with aflatoxins, [HSDB], Rubratoxin A is a mycotoxin produced by fungi such as Penicillum rubrum and Penicillum purpurogenum, which are common soil fungi that sometimes contaminate animal feeds. (A2985, A2988), Methods of Manufacturing: A STERILE GLUCOSE-MINERAL SALTS BROTH WAS INOCULATED WITH SPORE SUSPENSIONS OR MYCELIAL PELLETS OF PENICILLIUM RUBRUM AND INCUBATED QUIESCENTLY FOR 14 DAYS. RUBRATOXINS WERE RECOVERED FROM CULTURE FILTRATES BY ETHER EXTRACTION AND RESOLVED BY TLC. TOXIN FORMATION WAS ENHANCED BY MALONATE BUT WAS NOT MARKEDLY AFFECTED BY ETHYL MALONATE, SHIKIMATE, AND ACETATE OR BY ISOCITRATE OR OXALOACETATE ADDED IN THE PRESENCE OF MALONATE. CITRATE, CIS-ACONITATE, ALPHA-KETOGLUTARATE, SUCCINATE, FUMARATE AND MALONATE WHEN PRESENT IN THE MEDIUM ALONE OR IN CONJUNCTION WITH MALONATE CAUSED A 15-50% REDUCTION IN RUBRATOXIN FORMATION. ACETYL-COA (10-15 MOL, FLAS) CAUSED AN 80% INCREASE IN TOXIN YIELD. AT 10-3 MOLAR, CITRATE STIMULATED RUBRATOXIN A PRODUCTION BY AS MUCH AS 100%. ABOVE 10-3 MOLAR, CITRATE INHIBITED TOXIN PRODUCTION. INCORPORATION OF (2-14)C-ACETATE INTO RUBRATOXIN WAS ENHANCED BY MALONATE AND FUMARATE + MALONATE. PYRUVATE + MALONATE PRODUCED A 40% INCREASE IN (2-14)C-ACETATE INCORPORATION INTO RUBRATOXIN. THE HIGHEST REDUCTION OF LABELED ACETATE INCORPORATION (36%) WAS CAUSED BY SUCCINATE OR ALPHA-KETOGLUTARATE COMBINED WITH MALONATE., General Manufacturing Information: MAXIMUM MOLD GROWTH AND TOXIN PRODUCTION WAS FAVORED BY 20% GLUCOSE. THE HIGHEST YIELD OF RUBRATOXIN A APPEARED IN 6 DAYS. |
| Category | Organic Chemicals |
Documented applications: Uses: Hepatotoxic metabolite from the molds Penicillium rubrum and P. purpurogenum, Often found growing in feedstuffs with Aspergillus sp., May coexist with aflatoxins, [HSDB], Rubratoxin A is a mycotoxin produced by fungi such as Penicillum rubrum and Penicillum purpurogenum, which are common soil fungi that sometimes contaminate animal feeds. (A2985, A2988), Methods of Manufacturing: A STERILE GLUCOSE-MINERAL SALTS BROTH WAS INOCULATED WITH SPORE SUSPENSIONS OR MYCELIAL PELLETS OF PENICILLIUM RUBRUM AND INCUBATED QUIESCENTLY FOR 14 DAYS. RUBRATOXINS WERE RECOVERED FROM CULTURE FILTRATES BY ETHER EXTRACTION AND RESOLVED BY TLC. TOXIN FORMATION WAS ENHANCED BY MALONATE BUT WAS NOT MARKEDLY AFFECTED BY ETHYL MALONATE, SHIKIMATE, AND ACETATE OR BY ISOCITRATE OR OXALOACETATE ADDED IN THE PRESENCE OF MALONATE. CITRATE, CIS-ACONITATE, ALPHA-KETOGLUTARATE, SUCCINATE, FUMARATE AND MALONATE WHEN PRESENT IN THE MEDIUM ALONE OR IN CONJUNCTION WITH MALONATE CAUSED A 15-50% REDUCTION IN RUBRATOXIN FORMATION. ACETYL-COA (10-15 MOL, FLAS) CAUSED AN 80% INCREASE IN TOXIN YIELD. AT 10-3 MOLAR, CITRATE STIMULATED RUBRATOXIN A PRODUCTION BY AS MUCH AS 100%. ABOVE 10-3 MOLAR, CITRATE INHIBITED TOXIN PRODUCTION. INCORPORATION OF (2-14)C-ACETATE INTO RUBRATOXIN WAS ENHANCED BY MALONATE AND FUMARATE + MALONATE. PYRUVATE + MALONATE PRODUCED A 40% INCREASE IN (2-14)C-ACETATE INCORPORATION INTO RUBRATOXIN. THE HIGHEST REDUCTION OF LABELED ACETATE INCORPORATION (36%) WAS CAUSED BY SUCCINATE OR ALPHA-KETOGLUTARATE COMBINED WITH MALONATE., General Manufacturing Information: MAXIMUM MOLD GROWTH AND TOXIN PRODUCTION WAS FAVORED BY 20% GLUCOSE. THE HIGHEST YIELD OF RUBRATOXIN A APPEARED IN 6 DAYS..
RUBRATOXINA is a carbon-based organic compound with CAS registry number 22467-31-8 and molecular formula C26H32O11 (molecular weight 520.5), belonging to the organic chemicals segment of chemical raw materials.
CAS number: 22467-31-8
Its molecular formula C26H32O11 comprises 26 C, 32 H, 11 O atoms.
Also known as: RUBRATOXINA · 化合物 Rubratoxin A
Category: organic chemicals
The CAS registry number of RUBRATOXINA is 22467-31-8.
Molecular formula C26H32O11, molecular weight 520.5.
It is also registered under: RUBRATOXINA, 化合物 Rubratoxin A.
Recorded applications: Uses: Hepatotoxic metabolite from the molds Penicillium rubrum and P. purpurogenum, Often found growing in feedstuffs with Aspergillus sp., May coexist with aflatoxins, [HSDB], Rubratoxin A is a mycotoxin produced by fungi such as Penicillum rubrum and Penicillum purpurogenum, which are common soil fungi that sometimes contaminate animal feeds. (A2985, A2988), Methods of Manufacturing: A STERILE GLUCOSE-MINERAL SALTS BROTH WAS INOCULATED WITH SPORE SUSPENSIONS OR MYCELIAL PELLETS OF PENICILLIUM RUBRUM AND INCUBATED QUIESCENTLY FOR 14 DAYS. RUBRATOXINS WERE RECOVERED FROM CULTURE FILTRATES BY ETHER EXTRACTION AND RESOLVED BY TLC. TOXIN FORMATION WAS ENHANCED BY MALONATE BUT WAS NOT MARKEDLY AFFECTED BY ETHYL MALONATE, SHIKIMATE, AND ACETATE OR BY ISOCITRATE OR OXALOACETATE ADDED IN THE PRESENCE OF MALONATE. CITRATE, CIS-ACONITATE, ALPHA-KETOGLUTARATE, SUCCINATE, FUMARATE AND MALONATE WHEN PRESENT IN THE MEDIUM ALONE OR IN CONJUNCTION WITH MALONATE CAUSED A 15-50% REDUCTION IN RUBRATOXIN FORMATION. ACETYL-COA (10-15 MOL, FLAS) CAUSED AN 80% INCREASE IN TOXIN YIELD. AT 10-3 MOLAR, CITRATE STIMULATED RUBRATOXIN A PRODUCTION BY AS MUCH AS 100%. ABOVE 10-3 MOLAR, CITRATE INHIBITED TOXIN PRODUCTION. INCORPORATION OF (2-14)C-ACETATE INTO RUBRATOXIN WAS ENHANCED BY MALONATE AND FUMARATE + MALONATE. PYRUVATE + MALONATE PRODUCED A 40% INCREASE IN (2-14)C-ACETATE INCORPORATION INTO RUBRATOXIN. THE HIGHEST REDUCTION OF LABELED ACETATE INCORPORATION (36%) WAS CAUSED BY SUCCINATE OR ALPHA-KETOGLUTARATE COMBINED WITH MALONATE., General Manufacturing Information: MAXIMUM MOLD GROWTH AND TOXIN PRODUCTION WAS FAVORED BY 20% GLUCOSE. THE HIGHEST YIELD OF RUBRATOXIN A APPEARED IN 6 DAYS..
Category: Organic Chemicals.
Independent reference data for RUBRATOXINA (CAS 22467-31-8), compiled from public chemistry databases.
| CAS 号 | 22467-31-8 |
|---|---|
| PubChem CID | 56840856 |
| 分子式 | C26H32O11 |
| IUPAC 名称 | (3S)-3,13-dihydroxy-2-[(1S)-1-hydroxyheptyl]-10-[(S)-hydroxy-(6-oxo-2,3-dihydropyran-2-yl)methyl]-6,14-dioxatricyclo[10.3.0.04,8]pentadeca-1(12),4(8)-diene-5,7,15-trione |
| Molecular Weight | 520.5 |
|---|---|
| XLogP3 | 1.4 |
| Hydrogen Bond Donor Count | 4 |
| Hydrogen Bond Acceptor Count | 11 |
| Rotatable Bond Count | 8 |
| Exact Mass | 520.19446183 |
| Monoisotopic Mass | 520.19446183 |
| Topological Polar Surface Area | 177 |
| Heavy Atom Count | 37 |
| Melting Point | 210-214 °C (dec.) |
|---|
RUBRATOXIN A; 22467-31-8; BRN 1633008; HSDB 3532; DTXSID20176998; 5-19-08-00329 (Beilstein Handbook Reference); RefChem:180230; DTXCID6099489; RUBRATOXINA; HB4063
化合物 Rubratoxin A · CAS 22467-31-8 · C26H32O11. Melting Point: 210-214 °C (dec.).
Source: PubChem / Wikidata; the batch COA governs where values differ.
Supplier: Jinan Shenghe Chemical Co., Ltd.
中文页面: 化合物 Rubratoxin A