rifampicin (CAS 13292-46-1) — formula C43H58N4O12, molecular weight 822.9; category organic chemicals.
| CAS Number | 13292-46-1 |
|---|---|
| Molecular Formula | C43H58N4O12 |
| Molecular Weight | 822.9 |
| Melting Point | 183 |
| LogP | 2.7 |
| Applications | Uses: Antibacterial (tuberculostatic), MEDICATION, Use (kg, approx.) in Germany (2009): >1000, Use (kg) in France (2004): 2383, Consumption (g per capita, approx.) in Germany (2009): 0.0122, Consumption (g per capita) in France (2004): 0.0394, Excretion rate: 0.18, Calculated removal (%): 42.1, For the treatment of Tuberculosis and Tuberculosis-related mycobacterial infections., Methods of Manufacturing: Rifamycin sv ... is converted to 8-carboxaldehyde derivative, known ... as 3-formylrifamycin sv, and this is condensed with 1-amino-4-methylpiperazine in schiff base reaction to yield rifampin., Rifamycin SV + dimethylformamide + N-methyl-piperazine (Vilsmeier reaction, diazotisation, reduction, imine formation), Semisynthetic antibiotic obtained by reacting 3-formylrifamycin SV with 1-amino-4-methylpiperazine in tetrahydrofuran., Formulations, Preparations: Oral: Capsules: 150 mg, Rifadin (Aventis), Rifampin Capsules (Eon), 300 mg, Rimacetane (with parabens) (Sandoz). Parenteral: For Injection: 600 mg Rifadin IV (with sodium formaldehyde sulfoxylate) (Aventis), Rifampin for Injection (Bedford)., General Manufacturing Information: The rifamycins are a group of structurally similar, complex macrocyclic antibiotics produced by Streptomyces mediterranei, rifampin ... is a semisynthetic derivative of one of these -- rifamycin B. |
| Category | Organic Chemicals |
Documented applications: Uses: Antibacterial (tuberculostatic), MEDICATION, Use (kg, approx.) in Germany (2009): >1000, Use (kg) in France (2004): 2383, Consumption (g per capita, approx.) in Germany (2009): 0.0122, Consumption (g per capita) in France (2004): 0.0394, Excretion rate: 0.18, Calculated removal (%): 42.1, For the treatment of Tuberculosis and Tuberculosis-related mycobacterial infections., Methods of Manufacturing: Rifamycin sv ... is converted to 8-carboxaldehyde derivative, known ... as 3-formylrifamycin sv, and this is condensed with 1-amino-4-methylpiperazine in schiff base reaction to yield rifampin., Rifamycin SV + dimethylformamide + N-methyl-piperazine (Vilsmeier reaction, diazotisation, reduction, imine formation), Semisynthetic antibiotic obtained by reacting 3-formylrifamycin SV with 1-amino-4-methylpiperazine in tetrahydrofuran., Formulations, Preparations: Oral: Capsules: 150 mg, Rifadin (Aventis), Rifampin Capsules (Eon), 300 mg, Rimacetane (with parabens) (Sandoz). Parenteral: For Injection: 600 mg Rifadin IV (with sodium formaldehyde sulfoxylate) (Aventis), Rifampin for Injection (Bedford)., General Manufacturing Information: The rifamycins are a group of structurally similar, complex macrocyclic antibiotics produced by Streptomyces mediterranei, rifampin ... is a semisynthetic derivative of one of these -- rifamycin B..
rifampicin is a carbon-based organic compound with CAS registry number 13292-46-1 and molecular formula C43H58N4O12 (molecular weight 822.9), belonging to the organic chemicals segment of chemical raw materials.
CAS number: 13292-46-1
Its molecular formula C43H58N4O12 comprises 43 C, 58 H, 4 N, 12 O atoms.
Also known as: rifampicin · 利福平
Category: organic chemicals
The CAS registry number of rifampicin is 13292-46-1.
Molecular formula C43H58N4O12, molecular weight 822.9.
It is also registered under: rifampicin, 利福平.
Recorded applications: Uses: Antibacterial (tuberculostatic), MEDICATION, Use (kg, approx.) in Germany (2009): >1000, Use (kg) in France (2004): 2383, Consumption (g per capita, approx.) in Germany (2009): 0.0122, Consumption (g per capita) in France (2004): 0.0394, Excretion rate: 0.18, Calculated removal (%): 42.1, For the treatment of Tuberculosis and Tuberculosis-related mycobacterial infections., Methods of Manufacturing: Rifamycin sv ... is converted to 8-carboxaldehyde derivative, known ... as 3-formylrifamycin sv, and this is condensed with 1-amino-4-methylpiperazine in schiff base reaction to yield rifampin., Rifamycin SV + dimethylformamide + N-methyl-piperazine (Vilsmeier reaction, diazotisation, reduction, imine formation), Semisynthetic antibiotic obtained by reacting 3-formylrifamycin SV with 1-amino-4-methylpiperazine in tetrahydrofuran., Formulations, Preparations: Oral: Capsules: 150 mg, Rifadin (Aventis), Rifampin Capsules (Eon), 300 mg, Rimacetane (with parabens) (Sandoz). Parenteral: For Injection: 600 mg Rifadin IV (with sodium formaldehyde sulfoxylate) (Aventis), Rifampin for Injection (Bedford)., General Manufacturing Information: The rifamycins are a group of structurally similar, complex macrocyclic antibiotics produced by Streptomyces mediterranei, rifampin ... is a semisynthetic derivative of one of these -- rifamycin B..
Category: Organic Chemicals.
Independent reference data for rifampicin (CAS 13292-46-1), compiled from public chemistry databases.
| CAS Registry Number | 13292-46-1 |
|---|---|
| PubChem CID | 135398735 |
| Molecular formula | C43H58N4O12 |
| IUPAC name | [(7S,9E,11S,12R,13S,14R,15R,16R,17S,18S,19E,21Z)-2,15,17,27,29-pentahydroxy-11-methoxy-3,7,12,14,16,18,22-heptamethyl-26-[(E)-(4-methylpiperazin-1-yl)iminomethyl]-6,23-dioxo-8,30-dioxa-24-azatetracyclo[23.3.1.14,7.05,28]triaconta-1(29),2,4,9,19,21,25,27-octaen-13-yl] acetate |
| UNII (FDA) | VJT6J7R4TR |
| Molecular Weight | 822.9 |
|---|---|
| XLogP3 | 4.9 |
| Hydrogen Bond Donor Count | 6 |
| Hydrogen Bond Acceptor Count | 15 |
| Rotatable Bond Count | 5 |
| Exact Mass | 822.40512330 |
| Monoisotopic Mass | 822.40512330 |
| Topological Polar Surface Area | 220 |
| Heavy Atom Count | 59 |
| Melting Point | 183 |
|---|---|
| Melting Point | Decomposes 183-188 °C |
| Solubility | 1400 |
| Solubility | In water, 1,400 mg/L at 25 °C |
| LogP | 2.7 |
| Dissociation Constants | 1.7 |
Rifampicin; rifampin; 13292-46-1; Rifaldazine; Rifamycin AMP; Rifaprodin; Rifoldin; Rifa; Rifampicinum; Riforal; Abrifam; Eremfat; L-5103 Lepetit; Rifaldin; Rifoldine; R/AMP
| Reported hazard statements | H302 (98.4%), H315 (85.2%), H319 (85.2%), H335 (83.6%) |
|---|
H302 (98.4%): Harmful if swallowed [Warning Acute toxicity, oral]
H315 (85.2%): Causes skin irritation [Warning Skin corrosion/irritation]
rifampicin · CAS 13292-46-1 · C43H58N4O12. UNII VJT6J7R4TR. Melting Point: 183; Melting Point: Decomposes 183-188 °C; Solubility: 1400.
Source: PubChem / Wikidata; the batch COA governs where values differ.
Supplier: Jinan Shenghe Chemical Co., Ltd.
中文页面: 利福平