利福平（CAS 13292-46-1）：分子式 C43H58N4O12、分子量 822.9。
| CAS号 | 13292-46-1 |
|---|---|
| 分子式 | C43H58N4O12 |
| 分子量 | 822.9 |
| 熔点 | 183 |
| LogP | 2.7 |
| 应用领域 | Uses: Antibacterial (tuberculostatic)、MEDICATION、Use (kg、approx.) in Germany (2009): >1000、Use (kg) in France (2004): 2383、Consumption (g per capita、approx.) in Germany (2009): 0.0122、Consumption (g per capita) in France (2004): 0.0394、Excretion rate: 0.18、Calculated removal (%): 42.1、For the treatment of Tuberculosis and Tuberculosis-related mycobacterial infections.、Methods of Manufacturing: Rifamycin sv ... is converted to 8-carboxaldehyde derivative、known ... as 3-formylrifamycin sv、and this is condensed with 1-amino-4-methylpiperazine in schiff base reaction to yield rifampin.、Rifamycin SV + dimethylformamide + N-methyl-piperazine (Vilsmeier reaction、diazotisation、reduction、imine formation)、Semisynthetic antibiotic obtained by reacting 3-formylrifamycin SV with 1-amino-4-methylpiperazine in tetrahydrofuran.、Formulations、Preparations: Oral: Capsules: 150 mg、Rifadin (Aventis)、Rifampin Capsules (Eon)、300 mg、Rimacetane (with parabens) (Sandoz). Parenteral: For Injection: 600 mg Rifadin IV (with sodium formaldehyde sulfoxylate) (Aventis)、Rifampin for Injection (Bedford).、General Manufacturing Information: The rifamycins are a group of structurally similar、complex macrocyclic antibiotics produced by Streptomyces mediterranei、rifampin ... is a semisynthetic derivative of one of these -- rifamycin B. |
登记用途：Uses: Antibacterial (tuberculostatic)、MEDICATION、Use (kg、approx.) in Germany (2009): >1000、Use (kg) in France (2004): 2383、Consumption (g per capita、approx.) in Germany (2009): 0.0122、Consumption (g per capita) in France (2004): 0.0394、Excretion rate: 0.18、Calculated removal (%): 42.1、For the treatment of Tuberculosis and Tuberculosis-related mycobacterial infections.、Methods of Manufacturing: Rifamycin sv ... is converted to 8-carboxaldehyde derivative、known ... as 3-formylrifamycin sv、and this is condensed with 1-amino-4-methylpiperazine in schiff base reaction to yield rifampin.、Rifamycin SV + dimethylformamide + N-methyl-piperazine (Vilsmeier reaction、diazotisation、reduction、imine formation)、Semisynthetic antibiotic obtained by reacting 3-formylrifamycin SV with 1-amino-4-methylpiperazine in tetrahydrofuran.、Formulations、Preparations: Oral: Capsules: 150 mg、Rifadin (Aventis)、Rifampin Capsules (Eon)、300 mg、Rimacetane (with parabens) (Sandoz). Parenteral: For Injection: 600 mg Rifadin IV (with sodium formaldehyde sulfoxylate) (Aventis)、Rifampin for Injection (Bedford).、General Manufacturing Information: The rifamycins are a group of structurally similar、complex macrocyclic antibiotics produced by Streptomyces mediterranei、rifampin ... is a semisynthetic derivative of one of these -- rifamycin B.。
利福平 是一种化工化合物，登记 CAS 号为 13292-46-1，分子式 C43H58N4O12（分子量 822.9）。
登记 CAS 号：13292-46-1
其分子式 C43H58N4O12 由 43 个碳、58 个氢、4 个氮、12 个氧 组成。
别名/同义词：利福平 · rifampicin
利福平 的 CAS 登记号为 13292-46-1。
分子式 C43H58N4O12，分子量 822.9。
别名/同义词：利福平、rifampicin。
登记用途：Uses: Antibacterial (tuberculostatic)、MEDICATION、Use (kg、approx.) in Germany (2009): >1000、Use (kg) in France (2004): 2383、Consumption (g per capita、approx.) in Germany (2009): 0.0122、Consumption (g per capita) in France (2004): 0.0394、Excretion rate: 0.18、Calculated removal (%): 42.1、For the treatment of Tuberculosis and Tuberculosis-related mycobacterial infections.、Methods of Manufacturing: Rifamycin sv ... is converted to 8-carboxaldehyde derivative、known ... as 3-formylrifamycin sv、and this is condensed with 1-amino-4-methylpiperazine in schiff base reaction to yield rifampin.、Rifamycin SV + dimethylformamide + N-methyl-piperazine (Vilsmeier reaction、diazotisation、reduction、imine formation)、Semisynthetic antibiotic obtained by reacting 3-formylrifamycin SV with 1-amino-4-methylpiperazine in tetrahydrofuran.、Formulations、Preparations: Oral: Capsules: 150 mg、Rifadin (Aventis)、Rifampin Capsules (Eon)、300 mg、Rimacetane (with parabens) (Sandoz). Parenteral: For Injection: 600 mg Rifadin IV (with sodium formaldehyde sulfoxylate) (Aventis)、Rifampin for Injection (Bedford).、General Manufacturing Information: The rifamycins are a group of structurally similar、complex macrocyclic antibiotics produced by Streptomyces mediterranei、rifampin ... is a semisynthetic derivative of one of these -- rifamycin B.。
利福平（CAS 13292-46-1）的独立参考数据，整理自公开化学数据库。
| CAS Registry Number | 13292-46-1 |
|---|---|
| PubChem CID | 135398735 |
| Molecular formula | C43H58N4O12 |
| IUPAC name | [(7S,9E,11S,12R,13S,14R,15R,16R,17S,18S,19E,21Z)-2,15,17,27,29-pentahydroxy-11-methoxy-3,7,12,14,16,18,22-heptamethyl-26-[(E)-(4-methylpiperazin-1-yl)iminomethyl]-6,23-dioxo-8,30-dioxa-24-azatetracyclo[23.3.1.14,7.05,28]triaconta-1(29),2,4,9,19,21,25,27-octaen-13-yl] acetate |
| UNII (FDA) | VJT6J7R4TR |
| Molecular Weight | 822.9 |
|---|---|
| XLogP3 | 4.9 |
| Hydrogen Bond Donor Count | 6 |
| Hydrogen Bond Acceptor Count | 15 |
| Rotatable Bond Count | 5 |
| Exact Mass | 822.40512330 |
| Monoisotopic Mass | 822.40512330 |
| Topological Polar Surface Area | 220 |
| Heavy Atom Count | 59 |
| Melting Point | 183 |
|---|---|
| Melting Point | Decomposes 183-188 °C |
| Solubility | 1400 |
| Solubility | In water, 1,400 mg/L at 25 °C |
| LogP | 2.7 |
| Dissociation Constants | 1.7 |
Rifampicin; rifampin; 13292-46-1; Rifaldazine; Rifamycin AMP; Rifaprodin; Rifoldin; Rifa; Rifampicinum; Riforal; Abrifam; Eremfat; L-5103 Lepetit; Rifaldin; Rifoldine; R/AMP
| Reported hazard statements | H302 (98.4%), H315 (85.2%), H319 (85.2%), H335 (83.6%) |
|---|
H302 (98.4%): Harmful if swallowed [Warning Acute toxicity, oral]
H315 (85.2%): Causes skin irritation [Warning Skin corrosion/irritation]
rifampicin · CAS 13292-46-1 · C43H58N4O12. UNII VJT6J7R4TR. Melting Point: 183; Melting Point: Decomposes 183-188 °C; Solubility: 1400.
数据来源：PubChem / Wikidata；与随货 COA 不一致时以 COA 为准。
English page: rifampicin