Nafcillin sodium (CAS 985-16-0) — formula C21H22N2O5S, molecular weight 414.5; category organic chemicals.
| CAS Number | 985-16-0 |
|---|---|
| Molecular Formula | C21H22N2O5S |
| Molecular Weight | 414.5 |
| LogP | 3.3 |
| Applications | Uses: MEDICATION, MEDICATION (VET), Use Classification: Pharmaceuticals, Methods of Manufacturing: 6-AMINOPENICILLANIC ACID IS ACYLATED BY TREATMENT WITH 2-ETHOXY-1-NAPHTHOYL CHLORIDE IN ANHYDROUS ORG SOLVENT CONTAINING TRIETHYLAMINE. AQ EXTRACT OF THIS...IS ADMIXED WITH WATER-IMMISCIBLE SOLVENT & NAFCILLIN PPTD BY ADDN OF SULFURIC ACID. NAFCILLIN SODIUM IS PPTD BY MIXING ETHANOLIC SOLN OF ACID & SODIUM ETHYLHEXANOATE, Formulations, Preparations: POWDER FOR INJECTION IS BUFFERED WITH 40 MG SODIUM CITRATE, G OF DRUG, CAPSULES & TABLETS ARE BUFFERED WITH CALCIUM CARBONATE., NAFCILLIN SODIUM, USP (UNIPEN)...AVAILABLE FOR ORAL & PARENTERAL USE. CAPSULES USUALLY CONTAIN 250 MG...DRUG. SOLN IS ALSO MARKETED FOR ORAL USE. STERILE PREPN FOR INJECTION...AMPULS CONTAINING 500 MG, 1 G, OR 2 G OF SALT., General Manufacturing Information: ...A SEMISYNTHETIC PENICILLIN, DERIVED FROM 6-AMINOPENICILLANIC ACID, IS HIGHLY RESISTANT TO PENICILLINASE..., PATENTS: US PATENT 3, 157, 639., POTENCY: NOT LESS THAN 820 UG OF NAFCILLIN, MG., Doyle et al. Brit pat 880, 400 (1961 to Beecham), Nafcillin sodium |
| Category | Organic Chemicals |
Documented applications: Uses: MEDICATION, MEDICATION (VET), Use Classification: Pharmaceuticals, Methods of Manufacturing: 6-AMINOPENICILLANIC ACID IS ACYLATED BY TREATMENT WITH 2-ETHOXY-1-NAPHTHOYL CHLORIDE IN ANHYDROUS ORG SOLVENT CONTAINING TRIETHYLAMINE. AQ EXTRACT OF THIS...IS ADMIXED WITH WATER-IMMISCIBLE SOLVENT & NAFCILLIN PPTD BY ADDN OF SULFURIC ACID. NAFCILLIN SODIUM IS PPTD BY MIXING ETHANOLIC SOLN OF ACID & SODIUM ETHYLHEXANOATE, Formulations, Preparations: POWDER FOR INJECTION IS BUFFERED WITH 40 MG SODIUM CITRATE, G OF DRUG, CAPSULES & TABLETS ARE BUFFERED WITH CALCIUM CARBONATE., NAFCILLIN SODIUM, USP (UNIPEN)...AVAILABLE FOR ORAL & PARENTERAL USE. CAPSULES USUALLY CONTAIN 250 MG...DRUG. SOLN IS ALSO MARKETED FOR ORAL USE. STERILE PREPN FOR INJECTION...AMPULS CONTAINING 500 MG, 1 G, OR 2 G OF SALT., General Manufacturing Information: ...A SEMISYNTHETIC PENICILLIN, DERIVED FROM 6-AMINOPENICILLANIC ACID, IS HIGHLY RESISTANT TO PENICILLINASE..., PATENTS: US PATENT 3, 157, 639., POTENCY: NOT LESS THAN 820 UG OF NAFCILLIN, MG., Doyle et al. Brit pat 880, 400 (1961 to Beecham), Nafcillin sodium.
Nafcillin sodium is a carbon-based organic compound with CAS registry number 985-16-0 and molecular formula C21H22N2O5S (molecular weight 414.5), belonging to the organic chemicals segment of chemical raw materials.
CAS number: 985-16-0
Its molecular formula C21H22N2O5S comprises 21 C, 22 H, 2 N, 5 O, 1 S atoms.
Also known as: Nafcillin sodium · 萘夫西林钠
Category: organic chemicals
The CAS registry number of Nafcillin sodium is 985-16-0.
Molecular formula C21H22N2O5S, molecular weight 414.5.
It is also registered under: Nafcillin sodium, 萘夫西林钠.
Recorded applications: Uses: MEDICATION, MEDICATION (VET), Use Classification: Pharmaceuticals, Methods of Manufacturing: 6-AMINOPENICILLANIC ACID IS ACYLATED BY TREATMENT WITH 2-ETHOXY-1-NAPHTHOYL CHLORIDE IN ANHYDROUS ORG SOLVENT CONTAINING TRIETHYLAMINE. AQ EXTRACT OF THIS...IS ADMIXED WITH WATER-IMMISCIBLE SOLVENT & NAFCILLIN PPTD BY ADDN OF SULFURIC ACID. NAFCILLIN SODIUM IS PPTD BY MIXING ETHANOLIC SOLN OF ACID & SODIUM ETHYLHEXANOATE, Formulations, Preparations: POWDER FOR INJECTION IS BUFFERED WITH 40 MG SODIUM CITRATE, G OF DRUG, CAPSULES & TABLETS ARE BUFFERED WITH CALCIUM CARBONATE., NAFCILLIN SODIUM, USP (UNIPEN)...AVAILABLE FOR ORAL & PARENTERAL USE. CAPSULES USUALLY CONTAIN 250 MG...DRUG. SOLN IS ALSO MARKETED FOR ORAL USE. STERILE PREPN FOR INJECTION...AMPULS CONTAINING 500 MG, 1 G, OR 2 G OF SALT., General Manufacturing Information: ...A SEMISYNTHETIC PENICILLIN, DERIVED FROM 6-AMINOPENICILLANIC ACID, IS HIGHLY RESISTANT TO PENICILLINASE..., PATENTS: US PATENT 3, 157, 639., POTENCY: NOT LESS THAN 820 UG OF NAFCILLIN, MG., Doyle et al. Brit pat 880, 400 (1961 to Beecham), Nafcillin sodium.
Category: Organic Chemicals.
Independent reference data for Nafcillin sodium (CAS 985-16-0), compiled from public chemistry databases.
| CAS Registry Number | 985-16-0 |
|---|---|
| PubChem CID | 8982 |
| Molecular formula | C21H22N2O5S |
| IUPAC name | (2S,5R,6R)-6-[(2-ethoxynaphthalene-1-carbonyl)amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid |
| UNII (FDA) | 4CNZ27M7RV |
| Molecular Weight | 414.5 |
|---|---|
| XLogP3 | 2.9 |
| Hydrogen Bond Donor Count | 2 |
| Hydrogen Bond Acceptor Count | 6 |
| Rotatable Bond Count | 5 |
| Exact Mass | 414.12494298 |
| Monoisotopic Mass | 414.12494298 |
| Topological Polar Surface Area | 121 |
| Heavy Atom Count | 29 |
| Solubility | 1.72e-02 g/L |
|---|---|
| LogP | 3.3 |
nafcillin; 147-52-4; Naphcillin; Nafcilina; Nafcilline; Nafcillinum; Nafcilin-1; (2-Ethoxy-1-naphthyl)penicillin; (2-ethoxy-1-naphthalenyl)penicillin; CHEBI:7447; Penicillin, (2-ethoxy-1-naphthalenyl)-; 4CNZ27M7RV; Penicillin, (2-ethoxy-1-naphthyl)-; 6-(2-ethoxy-1-naphthamido)penicillanic acid; DTXSID8023343; 4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 6-(2-ethoxy-1-naphthamido)-3,3-dimethyl-7-oxo-
| Reported hazard statements | H317 (100%), H334 (100%) |
|---|
H317 (100%): May cause an allergic skin reaction [Warning Sensitization, Skin]
H334 (100%): May cause allergy or asthma symptoms or breathing difficulties if inhaled [Danger Sensitization, respiratory]
Nafcillin sodium · CAS 985-16-0 · C21H22N2O5S. UNII 4CNZ27M7RV. Solubility: 1.72e-02 g/L; LogP: 3.3.
Source: PubChem / Wikidata; the batch COA governs where values differ.
Supplier: Jinan Shenghe Chemical Co., Ltd.
中文页面: 萘夫西林钠