Mefloquine (CAS 53230-10-7) — formula C17H16F6N2O, molecular weight 378.31; category organic chemicals.
| CAS Number | 53230-10-7 |
|---|---|
| Molecular Formula | C17H16F6N2O |
| Molecular Weight | 378.31 |
| Melting Point | 250-254 |
| Boiling Point | 415.7±40.0 °C |
| LogP | 3.9 |
| Applications | Uses: Antimalarials, MEDICATION, Use (kg, approx.) in Germany (2009): >100, Consumption (g per capita, approx.) in Germany (2009): 0.00122, Calculated removal (%): 55.5, Methods of Manufacturing: Preparation of erythro-form: G. Grethe, T. Mitt, German patent 2806909, H. Bomches, B. Hardegger, United States of America patent 4507482 (1978, 1985 both to Hoffman-La Roche)., Formulations, Preparations: Fansimef is a combination of mefloquine with Fansidar (pyrimethamine and sulfadoxine), Mefloquine hydrochloride, Table: Mefloquine Hydrochloride Preparations [Table#6364], General Manufacturing Information: A 250 mg tablet is equivalent to 228 mg of mefloquine base. The product available in Canada and other countries is 250 mg of mefloquine base, equivalent to 274 mg of mefloquine hydrochloride. |
| Category | Organic Chemicals |
Documented applications: Uses: Antimalarials, MEDICATION, Use (kg, approx.) in Germany (2009): >100, Consumption (g per capita, approx.) in Germany (2009): 0.00122, Calculated removal (%): 55.5, Methods of Manufacturing: Preparation of erythro-form: G. Grethe, T. Mitt, German patent 2806909, H. Bomches, B. Hardegger, United States of America patent 4507482 (1978, 1985 both to Hoffman-La Roche)., Formulations, Preparations: Fansimef is a combination of mefloquine with Fansidar (pyrimethamine and sulfadoxine), Mefloquine hydrochloride, Table: Mefloquine Hydrochloride Preparations [Table#6364], General Manufacturing Information: A 250 mg tablet is equivalent to 228 mg of mefloquine base. The product available in Canada and other countries is 250 mg of mefloquine base, equivalent to 274 mg of mefloquine hydrochloride..
Mefloquine is a carbon-based organic compound with CAS registry number 53230-10-7 and molecular formula C17H16F6N2O (molecular weight 378.31), belonging to the organic chemicals segment of chemical raw materials.
CAS number: 53230-10-7
Its molecular formula C17H16F6N2O comprises 17 C, 16 H, 6 F, 2 N, 1 O atoms.
Also known as: Mefloquine · 甲氟喹
Category: organic chemicals
The CAS registry number of Mefloquine is 53230-10-7.
Molecular formula C17H16F6N2O, molecular weight 378.31.
It is also registered under: Mefloquine, 甲氟喹.
Recorded applications: Uses: Antimalarials, MEDICATION, Use (kg, approx.) in Germany (2009): >100, Consumption (g per capita, approx.) in Germany (2009): 0.00122, Calculated removal (%): 55.5, Methods of Manufacturing: Preparation of erythro-form: G. Grethe, T. Mitt, German patent 2806909, H. Bomches, B. Hardegger, United States of America patent 4507482 (1978, 1985 both to Hoffman-La Roche)., Formulations, Preparations: Fansimef is a combination of mefloquine with Fansidar (pyrimethamine and sulfadoxine), Mefloquine hydrochloride, Table: Mefloquine Hydrochloride Preparations [Table#6364], General Manufacturing Information: A 250 mg tablet is equivalent to 228 mg of mefloquine base. The product available in Canada and other countries is 250 mg of mefloquine base, equivalent to 274 mg of mefloquine hydrochloride..
Category: Organic Chemicals.
Independent reference data for Mefloquine (CAS 53230-10-7), compiled from public chemistry databases.
| CAS Registry Number | 53230-10-7 |
|---|---|
| PubChem CID | 4046 |
| Molecular formula | C17H16F6N2O |
| IUPAC name | [2,8-bis(trifluoromethyl)quinolin-4-yl]-piperidin-2-ylmethanol |
| UNII (FDA) | TML814419R |
| Molecular Weight | 378.31 |
|---|---|
| XLogP3 | 3.6 |
| Hydrogen Bond Donor Count | 2 |
| Hydrogen Bond Acceptor Count | 9 |
| Rotatable Bond Count | 2 |
| Exact Mass | 378.11668211 |
| Monoisotopic Mass | 378.11668211 |
| Topological Polar Surface Area | 45.2 |
| Heavy Atom Count | 26 |
| Boiling Point | 415.7±40.0 °C |
|---|---|
| Melting Point | 250-254 |
| Melting Point | 174-176 °C |
| Solubility | 1.806 |
| Solubility | 3.80e-02 g/L |
| LogP | 3.9 |
| Dissociation Constants | 8.6 |
mefloquine; Mefloquina; 53230-10-7; GNF-Pf-5544; Racemic mefloquine; [2,8-bis(trifluoromethyl)quinolin-4-yl]-piperidin-2-ylmethanol; Mefloquinum; Ro-215998; NSC-758233; Ro 21-5998; WR 142,490; DTXSID4037168; Mephloquine; (2,8-bis(trifluoromethyl)quinolin-4-yl)-piperidin-2-ylmethanol; RefChem:56342; CHEBI:63609
| Reported hazard statements | H302 |
|---|
H302: Harmful if swallowed [Warning Acute toxicity, oral]
P264, P270, P301+P317, P330, and P501 (click each P-code to see the statement)
Mefloquine · CAS 53230-10-7 · C17H16F6N2O. UNII TML814419R. Boiling Point: 415.7±40.0 °C; Melting Point: 250-254; Melting Point: 174-176 °C.
Source: PubChem / Wikidata; the batch COA governs where values differ.
Supplier: Jinan Shenghe Chemical Co., Ltd.
中文页面: 甲氟喹