丙二酸（CAS 141-82-2）：分子式 C3H4O4、分子量 104.06；类别 食品添加剂。
| CAS号 | 141-82-2 |
|---|---|
| 分子式 | C3H4O4 |
| 分子量 | 104.06 |
| 熔点 | 276.1 °F (NTP, 1992) |
| 沸点 | Decomposes above 140 °C |
| LogP | -0.8 |
| 应用领域 | Uses: CIR ingredient: Malonic Acid、Used to make barbiturates、[Merck Index]、Intermediate for barbiturates and pharmaceuticals.、Malonic acid is used for the introduction of an acetic acid moiety under mild conditions by Knoevenagel condensation and subsequent decarboxylation. Examples include the preparation of cinnamic acid、used for the production of the anti-inflammatory cinmetacin and 3、4、5-trimethoxycinnamic acid、the key intermediate of the vasodilators cinepazet and cinepazide. The fragrance gamma-nonanoic lactone is available by Knoevenagel condensation of malonic acid with heptaldehyde followed by ring closure.、...、The、diethyl ester is used in syntheses of vitamins B1 and B6、barbiturates、and numerous other valuable compounds. Malonic acid itself is rather unstable and has few applications.、Malonic acid may be used as a cross-linking agent between corn starch and potato starch to improve its mechanical properties.、MEDICATION (VET)、Use Classification: Cosmetics -> Buffering、Industry Uses: Chelating agent、Etching agent、Plating agent、Abrasives、Methods of Manufacturing: Malonic acid is usually produced by hydrolysis of cyanoacetic acid or by acid saponification of malonates. Alternative more recently reported methods for the preparation of malonic acid are the ozonolysis of cyclopentadiene、the palladium-catalyzed air oxidation of 1、3-propanediol、the platinum group metalcatalyzed oxidation of 3-hydroxypropionaldehyde or 3-hydroxypropionic acid and the use of malononitrile as a substrate for a nitrilase.、From monochloroacetic acid by reaction with potassium cyanide followed by hydrolysis.、U.S. Production: 2023: <75、000 lb、2022: <75、2021: <75、2020: <75、Non-confidential 2016 Chemical Data Reporting (CDR) information on the production and use of chemicals manufactured or imported into the United States. Chemical: Malonic acid:、Table: National Aggregate Production Volume (pounds) [Table#8507]、General Manufacturing Information: All Other Chemical Product and Preparation Manufacturing、Propanedioic acid: ACTIVE、The occurrence of malonic acid has been reported in the leaves of lucerne and in green wheat plants. This acid is well known as a competitive inhibitor of succinic dehydrogenase、and has been used extensively in investigations of the tricarboxylic acid cycle. |
| 类别 | 其他食品添加剂 |
登记用途：Uses: CIR ingredient: Malonic Acid、Used to make barbiturates、[Merck Index]、Intermediate for barbiturates and pharmaceuticals.、Malonic acid is used for the introduction of an acetic acid moiety under mild conditions by Knoevenagel condensation and subsequent decarboxylation. Examples include the preparation of cinnamic acid、used for the production of the anti-inflammatory cinmetacin and 3、4、5-trimethoxycinnamic acid、the key intermediate of the vasodilators cinepazet and cinepazide. The fragrance gamma-nonanoic lactone is available by Knoevenagel condensation of malonic acid with heptaldehyde followed by ring closure.、...、The、diethyl ester is used in syntheses of vitamins B1 and B6、barbiturates、and numerous other valuable compounds. Malonic acid itself is rather unstable and has few applications.、Malonic acid may be used as a cross-linking agent between corn starch and potato starch to improve its mechanical properties.、MEDICATION (VET)、Use Classification: Cosmetics -> Buffering、Industry Uses: Chelating agent、Etching agent、Plating agent、Abrasives、Methods of Manufacturing: Malonic acid is usually produced by hydrolysis of cyanoacetic acid or by acid saponification of malonates. Alternative more recently reported methods for the preparation of malonic acid are the ozonolysis of cyclopentadiene、the palladium-catalyzed air oxidation of 1、3-propanediol、the platinum group metalcatalyzed oxidation of 3-hydroxypropionaldehyde or 3-hydroxypropionic acid and the use of malononitrile as a substrate for a nitrilase.、From monochloroacetic acid by reaction with potassium cyanide followed by hydrolysis.、U.S. Production: 2023: <75、000 lb、2022: <75、2021: <75、2020: <75、Non-confidential 2016 Chemical Data Reporting (CDR) information on the production and use of chemicals manufactured or imported into the United States. Chemical: Malonic acid:、Table: National Aggregate Production Volume (pounds) [Table#8507]、General Manufacturing Information: All Other Chemical Product and Preparation Manufacturing、Propanedioic acid: ACTIVE、The occurrence of malonic acid has been reported in the leaves of lucerne and in green wheat plants. This acid is well known as a competitive inhibitor of succinic dehydrogenase、and has been used extensively in investigations of the tricarboxylic acid cycle.。
丙二酸 是一种食品级化合物，登记 CAS 号为 141-82-2，分子式 C3H4O4（分子量 104.06），归属于食品添加剂大类化工原料。
登记 CAS 号：141-82-2
其分子式 C3H4O4 由 3 个碳、4 个氢、4 个氧 组成。
别名/同义词：丙二酸 · malonic acid · Dicarboxylic acid
所属分类：食品添加剂
丙二酸 的 CAS 登记号为 141-82-2。
分子式 C3H4O4，分子量 104.06。
别名/同义词：丙二酸、malonic acid、Dicarboxylic acid。
登记用途：Uses: CIR ingredient: Malonic Acid、Used to make barbiturates、[Merck Index]、Intermediate for barbiturates and pharmaceuticals.、Malonic acid is used for the introduction of an acetic acid moiety under mild conditions by Knoevenagel condensation and subsequent decarboxylation. Examples include the preparation of cinnamic acid、used for the production of the anti-inflammatory cinmetacin and 3、4、5-trimethoxycinnamic acid、the key intermediate of the vasodilators cinepazet and cinepazide. The fragrance gamma-nonanoic lactone is available by Knoevenagel condensation of malonic acid with heptaldehyde followed by ring closure.、...、The、diethyl ester is used in syntheses of vitamins B1 and B6、barbiturates、and numerous other valuable compounds. Malonic acid itself is rather unstable and has few applications.、Malonic acid may be used as a cross-linking agent between corn starch and potato starch to improve its mechanical properties.、MEDICATION (VET)、Use Classification: Cosmetics -> Buffering、Industry Uses: Chelating agent、Etching agent、Plating agent、Abrasives、Methods of Manufacturing: Malonic acid is usually produced by hydrolysis of cyanoacetic acid or by acid saponification of malonates. Alternative more recently reported methods for the preparation of malonic acid are the ozonolysis of cyclopentadiene、the palladium-catalyzed air oxidation of 1、3-propanediol、the platinum group metalcatalyzed oxidation of 3-hydroxypropionaldehyde or 3-hydroxypropionic acid and the use of malononitrile as a substrate for a nitrilase.、From monochloroacetic acid by reaction with potassium cyanide followed by hydrolysis.、U.S. Production: 2023: <75、000 lb、2022: <75、2021: <75、2020: <75、Non-confidential 2016 Chemical Data Reporting (CDR) information on the production and use of chemicals manufactured or imported into the United States. Chemical: Malonic acid:、Table: National Aggregate Production Volume (pounds) [Table#8507]、General Manufacturing Information: All Other Chemical Product and Preparation Manufacturing、Propanedioic acid: ACTIVE、The occurrence of malonic acid has been reported in the leaves of lucerne and in green wheat plants. This acid is well known as a competitive inhibitor of succinic dehydrogenase、and has been used extensively in investigations of the tricarboxylic acid cycle.。
所属分类：其他食品添加剂。
丙二酸（CAS 141-82-2）的独立参考数据，整理自公开化学数据库。
| CAS Registry Number | 141-82-2 |
|---|---|
| PubChem CID | 867 |
| Molecular formula | C3H4O4 |
| IUPAC name | propanedioic acid |
| UNII (FDA) | 9KX7ZMG0MK |
| Molecular Weight | 104.06 |
|---|---|
| XLogP3 | -0.8 |
| Hydrogen Bond Donor Count | 2 |
| Hydrogen Bond Acceptor Count | 4 |
| Rotatable Bond Count | 2 |
| Exact Mass | 104.01095860 |
| Monoisotopic Mass | 104.01095860 |
| Topological Polar Surface Area | 74.6 |
| Heavy Atom Count | 7 |
| Boiling Point | Decomposes above 140 °C |
|---|---|
| Melting Point | 276.1 °F (NTP, 1992) |
| Melting Point | 135 |
| Melting Point | 135-137 °C |
| Melting Point | 135 °C |
| Solubility | 763000 |
| Solubility | In water, 6.23X10+5 mg/L at 25 °C |
| Solubility | 763.0 mg/mL |
| Density | Density: 1.619 g/cu cm at 10 °C |
| Density | 1.6 g/cm³ |
malonic acid; propanedioic acid; 141-82-2; Dicarboxymethane; Carboxyacetic acid; Methanedicarboxylic acid; malonate; Kyselina malonova; USAF EK-695; 1,3-Propanedioic acid; DTXSID7021659; 9KX7ZMG0MK; NSC-8124; DTXCID401659; CHEBI:30794; malonyl
| Regulatory & Food Contact | EU Flavoring substances Flavoring Agents CIR / INCI: Cosmetic ingredients (Malonic Acid) -> CIR (Cosmetic Ingredient Review) |
|---|---|
| GHS notification summary | 1.4% (6 / 443) |
| GHS notification summary | 1.4% (6 / 443) |
|---|---|
| Reported hazard statements | H302 (47.2%), H315 (28.2%), H318 (49.7%), H319 (49%), H335 (11.5%) |
This chemical does not meet GHS hazard criteria for 1.4% (6 of 443) of reports.
H302 (47.2%): Harmful if swallowed [Warning Acute toxicity, oral]
Dicarboxylic acid · CAS 141-82-2 · C3H4O4. UNII 9KX7ZMG0MK. Boiling Point: Decomposes above 140 °C; Melting Point: 276.1 °F (NTP, 1992); Melting Point: 135.
数据来源：PubChem / Wikidata；与随货 COA 不一致时以 COA 为准。
English page: malonic acid