L-脯氨酸（CAS 147-85-3）：分子式 C5H9NO2、分子量 115.13；类别 食品添加剂。
| CAS号 | 147-85-3 |
|---|---|
| 分子式 | C5H9NO2 |
| 分子量 | 115.13 |
| 熔点 | 221 |
| LogP | -2.54 |
| 应用领域 | Uses: CIR ingredient: Proline、A non-essential amino acid、[Merck Index] Used in biochemical and nutritional research、pharmaceuticals for injection or infusion、microbiological tests、culture media、as a lab reagent、nutritional supplement、and starting material for captopril and enalapril、[HSDB] Used as a flavoring agent and nutritional supplement for foods、[FDA]、Reported uses (ppm):、Table: Reported uses (ppm): (Flavor and Extract Manufacturers' Association、1994) [Table#2999]、Biochemical and nutritional research、dietary supplement、lab reagent. Available commercially as the L(-)-proline.、Proline、Medical use: parenteral nutrition、...starting material for captopril and enalapril.、Used in pharmaceutical preparations for injection or infusion. Reactivation of nerve function、dietary supplement and flavor compounds in maillard reaction products、For more Uses (Complete) data for (L)-PROLINE (6 total)、please visit the HSDB record page.、Use (kg、approx.) in Germany (2009): >10000、Consumption (g per capita、approx.) in Germany (2009): 0.122、Calculated removal (%): 92.1、L-Proline is extremely important for the proper functioning of joints and tendons and also helps maintain and strengthen heart muscles.、Use Classification: Flavouring Agent -> FLAVOURING_AGENT -> JECFA Functional Classes、Flavoring Agents -> JECFA Flavorings Index、Cosmetics -> Antistatic、Skin conditioning、Hair conditioning、Industry Uses: Catalyst、Consumer Uses: Catalyst、Household Products: Information on 32 consumer products that contain Proline in the following categories is provided:、• Personal Care、Methods of Manufacturing: From alpha-piperidone、from cyclopentantone、from l-glutamic acid、Synthesis starting with gamma-bromopropylmalonic ester、... from gamma-phthalimidopropylmalonic ester、...from arylpiperidines、... from alpha-piperidone、... from alpha-pyrrolidonecarboxylic ester、... from cyclopentanone、... from levo-pyroglutamic acid.、Hydrolysis of protein、also synthetically and by recombinant DNA techniques.、L-Proline is still produced to a small extent by isolation from protein hydrolysates、but today direct fermentation using analogue-resistant mutants of coryneform bacteria or Serratia marcescens is an economic alternative production method. An isoleucine auxotrophic mutant of Brevibacterium flavum having resistance to sulfaguanidine and d、l-3、4-dehydroproline (DP) is able to accumulate 40 g、L l-proline. Brevibacterium flavum AP113 is claimed to produce 97.5 g、L l-proline、this mutant is characterized by isoleucine auxotrophy、resistance to DP、and osmotic pressure and incapable to degrade l-proline. A proline oxidase-less strain of Serratia marcescens、having resistance to DP、thiazoline-4-carboxylate and azetidine-2-carboxylate、overproduces 58.5 g、L l-proline into the culture medium. By amplification of the genes proA and proB in this type of regulatory mutant、a construct was obtained which yields 75 g、L l-proline.、Formulations、Preparations: USP and FCC grades、U.S. Production: 2023: 25、110 lb、2022: 30、820 lb、2021: 38、413 lb、2020: 31、226 lb、World market for L-proline in 1982: 100 tonnes、from table、World market for L-proline in 2005: 800 t、a、General Manufacturing Information: Pharmaceutical and Medicine Manufacturing、L-Proline: ACTIVE、Proline: ACTIVE、L-Proline is one of the twenty amino acids used in living organisms as the building blocks of proteins. Proline is sometimes called an imino acid、although the IUPAC definition of an imine requires a carbon-nitrogen double bond. Proline is a non-essential amino acid that is synthesized from glutamic acid.、SRP: A non-essential amino acid is considered "non-essential" because it can be made in the human body.、It is an essential component of collagen and is important for proper functioning of joints and tendons.、Non-essential amino acid for human develoment.、Proline composition of selected proteins: 6.3 g、100 g gelatin、11.3 g、100 g casein、5.1 g、16 g total nitrogen serum albumin、8.1 g、100 g gamma-globulin、8.5 g、100 g horse hemoglobin、2.5 g、100 g insulin、100 g clostridium botulinum toxin.、From table |
| 类别 | 营养强化剂 |
登记用途：Uses: CIR ingredient: Proline、A non-essential amino acid、[Merck Index] Used in biochemical and nutritional research、pharmaceuticals for injection or infusion、microbiological tests、culture media、as a lab reagent、nutritional supplement、and starting material for captopril and enalapril、[HSDB] Used as a flavoring agent and nutritional supplement for foods、[FDA]、Reported uses (ppm):、Table: Reported uses (ppm): (Flavor and Extract Manufacturers' Association、1994) [Table#2999]、Biochemical and nutritional research、dietary supplement、lab reagent. Available commercially as the L(-)-proline.、Proline、Medical use: parenteral nutrition、...starting material for captopril and enalapril.、Used in pharmaceutical preparations for injection or infusion. Reactivation of nerve function、dietary supplement and flavor compounds in maillard reaction products、For more Uses (Complete) data for (L)-PROLINE (6 total)、please visit the HSDB record page.、Use (kg、approx.) in Germany (2009): >10000、Consumption (g per capita、approx.) in Germany (2009): 0.122、Calculated removal (%): 92.1、L-Proline is extremely important for the proper functioning of joints and tendons and also helps maintain and strengthen heart muscles.、Use Classification: Flavouring Agent -> FLAVOURING_AGENT -> JECFA Functional Classes、Flavoring Agents -> JECFA Flavorings Index、Cosmetics -> Antistatic、Skin conditioning、Hair conditioning、Industry Uses: Catalyst、Consumer Uses: Catalyst、Household Products: Information on 32 consumer products that contain Proline in the following categories is provided:、• Personal Care、Methods of Manufacturing: From alpha-piperidone、from cyclopentantone、from l-glutamic acid、Synthesis starting with gamma-bromopropylmalonic ester、... from gamma-phthalimidopropylmalonic ester、...from arylpiperidines、... from alpha-piperidone、... from alpha-pyrrolidonecarboxylic ester、... from cyclopentanone、... from levo-pyroglutamic acid.、Hydrolysis of protein、also synthetically and by recombinant DNA techniques.、L-Proline is still produced to a small extent by isolation from protein hydrolysates、but today direct fermentation using analogue-resistant mutants of coryneform bacteria or Serratia marcescens is an economic alternative production method. An isoleucine auxotrophic mutant of Brevibacterium flavum having resistance to sulfaguanidine and d、l-3、4-dehydroproline (DP) is able to accumulate 40 g、L l-proline. Brevibacterium flavum AP113 is claimed to produce 97.5 g、L l-proline、this mutant is characterized by isoleucine auxotrophy、resistance to DP、and osmotic pressure and incapable to degrade l-proline. A proline oxidase-less strain of Serratia marcescens、having resistance to DP、thiazoline-4-carboxylate and azetidine-2-carboxylate、overproduces 58.5 g、L l-proline into the culture medium. By amplification of the genes proA and proB in this type of regulatory mutant、a construct was obtained which yields 75 g、L l-proline.、Formulations、Preparations: USP and FCC grades、U.S. Production: 2023: 25、110 lb、2022: 30、820 lb、2021: 38、413 lb、2020: 31、226 lb、World market for L-proline in 1982: 100 tonnes、from table、World market for L-proline in 2005: 800 t、a、General Manufacturing Information: Pharmaceutical and Medicine Manufacturing、L-Proline: ACTIVE、Proline: ACTIVE、L-Proline is one of the twenty amino acids used in living organisms as the building blocks of proteins. Proline is sometimes called an imino acid、although the IUPAC definition of an imine requires a carbon-nitrogen double bond. Proline is a non-essential amino acid that is synthesized from glutamic acid.、SRP: A non-essential amino acid is considered "non-essential" because it can be made in the human body.、It is an essential component of collagen and is important for proper functioning of joints and tendons.、Non-essential amino acid for human develoment.、Proline composition of selected proteins: 6.3 g、100 g gelatin、11.3 g、100 g casein、5.1 g、16 g total nitrogen serum albumin、8.1 g、100 g gamma-globulin、8.5 g、100 g horse hemoglobin、2.5 g、100 g insulin、100 g clostridium botulinum toxin.、From table。
L-脯氨酸 是一种食品级化合物，登记 CAS 号为 147-85-3，分子式 C5H9NO2（分子量 115.13），归属于食品添加剂大类化工原料。
登记 CAS 号：147-85-3
其分子式 C5H9NO2 由 5 个碳、9 个氢、1 个氮、2 个氧 组成。
别名/同义词：L-脯氨酸 · L(-)-Proline
所属分类：食品添加剂
L-脯氨酸 的 CAS 登记号为 147-85-3。
分子式 C5H9NO2，分子量 115.13。
别名/同义词：L-脯氨酸、L(-)-Proline。
登记用途：Uses: CIR ingredient: Proline、A non-essential amino acid、[Merck Index] Used in biochemical and nutritional research、pharmaceuticals for injection or infusion、microbiological tests、culture media、as a lab reagent、nutritional supplement、and starting material for captopril and enalapril、[HSDB] Used as a flavoring agent and nutritional supplement for foods、[FDA]、Reported uses (ppm):、Table: Reported uses (ppm): (Flavor and Extract Manufacturers' Association、1994) [Table#2999]、Biochemical and nutritional research、dietary supplement、lab reagent. Available commercially as the L(-)-proline.、Proline、Medical use: parenteral nutrition、...starting material for captopril and enalapril.、Used in pharmaceutical preparations for injection or infusion. Reactivation of nerve function、dietary supplement and flavor compounds in maillard reaction products、For more Uses (Complete) data for (L)-PROLINE (6 total)、please visit the HSDB record page.、Use (kg、approx.) in Germany (2009): >10000、Consumption (g per capita、approx.) in Germany (2009): 0.122、Calculated removal (%): 92.1、L-Proline is extremely important for the proper functioning of joints and tendons and also helps maintain and strengthen heart muscles.、Use Classification: Flavouring Agent -> FLAVOURING_AGENT -> JECFA Functional Classes、Flavoring Agents -> JECFA Flavorings Index、Cosmetics -> Antistatic、Skin conditioning、Hair conditioning、Industry Uses: Catalyst、Consumer Uses: Catalyst、Household Products: Information on 32 consumer products that contain Proline in the following categories is provided:、• Personal Care、Methods of Manufacturing: From alpha-piperidone、from cyclopentantone、from l-glutamic acid、Synthesis starting with gamma-bromopropylmalonic ester、... from gamma-phthalimidopropylmalonic ester、...from arylpiperidines、... from alpha-piperidone、... from alpha-pyrrolidonecarboxylic ester、... from cyclopentanone、... from levo-pyroglutamic acid.、Hydrolysis of protein、also synthetically and by recombinant DNA techniques.、L-Proline is still produced to a small extent by isolation from protein hydrolysates、but today direct fermentation using analogue-resistant mutants of coryneform bacteria or Serratia marcescens is an economic alternative production method. An isoleucine auxotrophic mutant of Brevibacterium flavum having resistance to sulfaguanidine and d、l-3、4-dehydroproline (DP) is able to accumulate 40 g、L l-proline. Brevibacterium flavum AP113 is claimed to produce 97.5 g、L l-proline、this mutant is characterized by isoleucine auxotrophy、resistance to DP、and osmotic pressure and incapable to degrade l-proline. A proline oxidase-less strain of Serratia marcescens、having resistance to DP、thiazoline-4-carboxylate and azetidine-2-carboxylate、overproduces 58.5 g、L l-proline into the culture medium. By amplification of the genes proA and proB in this type of regulatory mutant、a construct was obtained which yields 75 g、L l-proline.、Formulations、Preparations: USP and FCC grades、U.S. Production: 2023: 25、110 lb、2022: 30、820 lb、2021: 38、413 lb、2020: 31、226 lb、World market for L-proline in 1982: 100 tonnes、from table、World market for L-proline in 2005: 800 t、a、General Manufacturing Information: Pharmaceutical and Medicine Manufacturing、L-Proline: ACTIVE、Proline: ACTIVE、L-Proline is one of the twenty amino acids used in living organisms as the building blocks of proteins. Proline is sometimes called an imino acid、although the IUPAC definition of an imine requires a carbon-nitrogen double bond. Proline is a non-essential amino acid that is synthesized from glutamic acid.、SRP: A non-essential amino acid is considered "non-essential" because it can be made in the human body.、It is an essential component of collagen and is important for proper functioning of joints and tendons.、Non-essential amino acid for human develoment.、Proline composition of selected proteins: 6.3 g、100 g gelatin、11.3 g、100 g casein、5.1 g、16 g total nitrogen serum albumin、8.1 g、100 g gamma-globulin、8.5 g、100 g horse hemoglobin、2.5 g、100 g insulin、100 g clostridium botulinum toxin.、From table。
所属分类：营养强化剂。
L-脯氨酸（CAS 147-85-3）的独立参考数据，整理自公开化学数据库。
| CAS 号 | 147-85-3 |
|---|---|
| PubChem CID | 145742 |
| 分子式 | C5H9NO2 |
| 分子量 | 115.06 g/mol |
| IUPAC 名称 | (2S)-pyrrolidine-2-carboxylic acid |
| InChIKey | ONIBWKKTOPOVIA-BYPYZUCNSA-N |
| UNII（FDA） | 9DLQ4CIU6V |
| ChEBI 编号 | CHEBI:17203 |
| FEMA 编号 | 3319 |
| JECFA 编号 | 1425 |
| Molecular Weight | 115.13 |
|---|---|
| XLogP3 | -2.5 |
| Hydrogen Bond Donor Count | 2 |
| Hydrogen Bond Acceptor Count | 3 |
| Rotatable Bond Count | 1 |
| Exact Mass | 115.063328530 |
| Monoisotopic Mass | 115.063328530 |
| Topological Polar Surface Area | 49.3 |
| Heavy Atom Count | 8 |
| Melting Point | 221 |
|---|---|
| Melting Point | 220-222 °C, decomposes |
| Melting Point | 221 °C |
| Solubility | 162000 |
| Solubility | 162.0 mg/mL |
| Density | 1.064 at 24 °C |
| LogP | -2.54 |
| LogP | log Kow = -2.54 |
| Ionization Efficiency | 2.63 |
| Ionization Efficiency | 2.7 |
L-proline; 147-85-3; proline; L-(-)-Proline; (2S)-pyrrolidine-2-carboxylic acid; (S)-Pyrrolidine-2-carboxylic acid; (-)-Proline; 2-pyrrolidinecarboxylic acid; (-)-(S)-Proline; (S)-2-Pyrrolidinecarboxylic acid; prolina; Prolinum; (S)-Proline; (-)-2-Pyrrolidinecarboxylic acid; L-Prolin; L-alpha-Pyrrolidinecarboxylic acid
| 法规与食品接触 | EU Flavoring substances FDA Substance added to food: FLAVOR ENHANCER, FLAVORING AGENT OR ADJUVANT, NUTRIENT SUPPLEMENT Flavoring Agents FLAVOURING_AGENT: Flavouring Agent Mouthfeel No safety concern at current levels of intake when used as a flavouring agent |
|---|---|
| GHS 通报统计 | 99.1% (419 / 423) |
| GHS 通报统计 | 99.1% (419 / 423) |
|---|
L-脯氨酸 的 CAS 号为 147-85-3，分子式 C5H9NO2，分子量 115.06 g/mol。 UNII 9DLQ4CIU6V; ChEBI 17203; InChIKey ONIBWKKTOPOVIA-BYPYZUCNSA-N. Melting Point: 221; Melting Point: 220-222 °C, decomposes; Melting Point: 221 °C.
数据来源：PubChem / Wikidata；与随货 COA 不一致时以 COA 为准。
English page: L(-)-Proline