L-Histidine（CAS 71-00-1）：分子式 C6H9N3O2、分子量 155.15；类别 食品添加剂。
| CAS号 | 71-00-1 |
|---|---|
| 分子式 | C6H9N3O2 |
| 分子量 | 155.15 |
| 熔点 | 287 |
| LogP | -3.32 |
| 应用领域 | Uses: CIR ingredient: Histidine、An essential amino acid、[Merck Index] Used as a medicine、feed additive、dietary supplement、in biochemical research、infusion solutions、diagnostic aids、and as a starting material for peptide drugs、[HSDB] Used as a flavoring agent and nutritional supplement for foods、[FDA]、Farming (Feed Additives) [Category: Industry]、Medicine、biochemical research、Infusion solutions、raw material (peptide drugs)、Use (kg、approx.) in Germany (2009): >10000、Consumption (g per capita、approx.) in Germany (2009): 0.122、Calculated removal (%): 75.1、The actions of supplemental L-histidine are entirely unclear. It may have some immunomodulatory as well as antioxidant activity. L-histidine may be indicated for use in some with rheumatoid arthritis. It is not indicated for treatment of anemia or uremia or for lowering serum cholesterol.、Use Classification: Flavouring Agent -> FLAVOURING_AGENT -> JECFA Functional Classes、Flavoring Agents -> JECFA Flavorings Index、Cosmetics -> Skin conditioning、Antistatic、Humectant、Household Products: Information on 165 consumer products that contain Histidine in the following categories is provided:、• Personal Care、Methods of Manufacturing: ISOLATED FROM BLOOD CORPUSCLES BY METHOD OF ELECTRICAL TRANSPORT... BY PRECIPITATION WITH MERCURIC CHLORIDE... CONVENIENT LAB PROCEDURES: FOSTER、SHEMIN、ORG SYN COLL VOL II、330 (1943). SYNTHESIS BY CONDENSING 4-CHLOROMETHYLGLYOXALINE WITH ETHYLCHLOROMALONATE: PYMAN、J CHEM SOC 99、668、1386 (1911)...、...BY CONDENSING GLYOXALINE FORMALDEHYDE WITH HIPPURIC ACID: PYMAN、J CHEM SOC 109、186 (1916).、From blood corpuscles、organic synthesis、Formulations、Preparations: ECRISTIDINE、& LAROSTIDIN.、L-HISTIDINE MONOHYDROCHLORIDE、Available commercially as L(+)-histidine hydrochloride and as the free base.、Found naturally in the L(-) form.、General Manufacturing Information: L-Histidine: ACTIVE、Histidine: ACTIVE |
| 类别 | 营养强化剂 |
登记用途：Uses: CIR ingredient: Histidine、An essential amino acid、[Merck Index] Used as a medicine、feed additive、dietary supplement、in biochemical research、infusion solutions、diagnostic aids、and as a starting material for peptide drugs、[HSDB] Used as a flavoring agent and nutritional supplement for foods、[FDA]、Farming (Feed Additives) [Category: Industry]、Medicine、biochemical research、Infusion solutions、raw material (peptide drugs)、Use (kg、approx.) in Germany (2009): >10000、Consumption (g per capita、approx.) in Germany (2009): 0.122、Calculated removal (%): 75.1、The actions of supplemental L-histidine are entirely unclear. It may have some immunomodulatory as well as antioxidant activity. L-histidine may be indicated for use in some with rheumatoid arthritis. It is not indicated for treatment of anemia or uremia or for lowering serum cholesterol.、Use Classification: Flavouring Agent -> FLAVOURING_AGENT -> JECFA Functional Classes、Flavoring Agents -> JECFA Flavorings Index、Cosmetics -> Skin conditioning、Antistatic、Humectant、Household Products: Information on 165 consumer products that contain Histidine in the following categories is provided:、• Personal Care、Methods of Manufacturing: ISOLATED FROM BLOOD CORPUSCLES BY METHOD OF ELECTRICAL TRANSPORT... BY PRECIPITATION WITH MERCURIC CHLORIDE... CONVENIENT LAB PROCEDURES: FOSTER、SHEMIN、ORG SYN COLL VOL II、330 (1943). SYNTHESIS BY CONDENSING 4-CHLOROMETHYLGLYOXALINE WITH ETHYLCHLOROMALONATE: PYMAN、J CHEM SOC 99、668、1386 (1911)...、...BY CONDENSING GLYOXALINE FORMALDEHYDE WITH HIPPURIC ACID: PYMAN、J CHEM SOC 109、186 (1916).、From blood corpuscles、organic synthesis、Formulations、Preparations: ECRISTIDINE、& LAROSTIDIN.、L-HISTIDINE MONOHYDROCHLORIDE、Available commercially as L(+)-histidine hydrochloride and as the free base.、Found naturally in the L(-) form.、General Manufacturing Information: L-Histidine: ACTIVE、Histidine: ACTIVE。
L-Histidine 是一种食品级化合物，登记 CAS 号为 71-00-1，分子式 C6H9N3O2（分子量 155.15），归属于食品添加剂大类化工原料。
登记 CAS 号：71-00-1
其分子式 C6H9N3O2 由 6 个碳、9 个氢、3 个氮、2 个氧 组成。
别名/同义词：L-Histidine
所属分类：食品添加剂
L-Histidine 的 CAS 登记号为 71-00-1。
分子式 C6H9N3O2，分子量 155.15。
别名/同义词：L-Histidine。
登记用途：Uses: CIR ingredient: Histidine、An essential amino acid、[Merck Index] Used as a medicine、feed additive、dietary supplement、in biochemical research、infusion solutions、diagnostic aids、and as a starting material for peptide drugs、[HSDB] Used as a flavoring agent and nutritional supplement for foods、[FDA]、Farming (Feed Additives) [Category: Industry]、Medicine、biochemical research、Infusion solutions、raw material (peptide drugs)、Use (kg、approx.) in Germany (2009): >10000、Consumption (g per capita、approx.) in Germany (2009): 0.122、Calculated removal (%): 75.1、The actions of supplemental L-histidine are entirely unclear. It may have some immunomodulatory as well as antioxidant activity. L-histidine may be indicated for use in some with rheumatoid arthritis. It is not indicated for treatment of anemia or uremia or for lowering serum cholesterol.、Use Classification: Flavouring Agent -> FLAVOURING_AGENT -> JECFA Functional Classes、Flavoring Agents -> JECFA Flavorings Index、Cosmetics -> Skin conditioning、Antistatic、Humectant、Household Products: Information on 165 consumer products that contain Histidine in the following categories is provided:、• Personal Care、Methods of Manufacturing: ISOLATED FROM BLOOD CORPUSCLES BY METHOD OF ELECTRICAL TRANSPORT... BY PRECIPITATION WITH MERCURIC CHLORIDE... CONVENIENT LAB PROCEDURES: FOSTER、SHEMIN、ORG SYN COLL VOL II、330 (1943). SYNTHESIS BY CONDENSING 4-CHLOROMETHYLGLYOXALINE WITH ETHYLCHLOROMALONATE: PYMAN、J CHEM SOC 99、668、1386 (1911)...、...BY CONDENSING GLYOXALINE FORMALDEHYDE WITH HIPPURIC ACID: PYMAN、J CHEM SOC 109、186 (1916).、From blood corpuscles、organic synthesis、Formulations、Preparations: ECRISTIDINE、& LAROSTIDIN.、L-HISTIDINE MONOHYDROCHLORIDE、Available commercially as L(+)-histidine hydrochloride and as the free base.、Found naturally in the L(-) form.、General Manufacturing Information: L-Histidine: ACTIVE、Histidine: ACTIVE。
所属分类：营养强化剂。
L-Histidine（CAS 71-00-1）的独立参考数据，整理自公开化学数据库。
| CAS 号 | 71-00-1 |
|---|---|
| PubChem CID | 6274 |
| 分子式 | C6H9N3O2 |
| 分子量 | 155.07 g/mol |
| IUPAC 名称 | (2S)-2-amino-3-(1H-imidazol-5-yl)propanoic acid |
| InChIKey | HNDVDQJCIGZPNO-YFKPBYRVSA-N |
| UNII（FDA） | 4QD397987E |
| ChEBI 编号 | CHEBI:15971 |
| FEMA 编号 | 3694 |
| JECFA 编号 | 1431 |
| Molecular Weight | 155.15 |
|---|---|
| XLogP3 | -3.2 |
| Hydrogen Bond Donor Count | 3 |
| Hydrogen Bond Acceptor Count | 4 |
| Rotatable Bond Count | 3 |
| Exact Mass | 155.069476538 |
| Monoisotopic Mass | 155.069476538 |
| Topological Polar Surface Area | 92 |
| Heavy Atom Count | 11 |
| Melting Point | 287 |
|---|---|
| Melting Point | 287 °C (decomp) |
| Melting Point | 287 °C |
| Solubility | 45600 |
| Solubility | In water, 4.56X10+4 mg/l @ 25 °C |
| Solubility | 45.6 mg/mL |
| Vapor Pressure | 0.00000001 [mmHg] |
| LogP | -3.32 |
| LogP | log Kow= -3.32 |
| Ionization Efficiency | 3.04 |
L-histidine; histidine; 71-00-1; glyoxaline-5-alanine; L-(-)-Histidine; histidina; Istidina; HISTIDINE, L-; L-Histidin; (2S)-2-amino-3-(1H-imidazol-4-yl)propanoic acid; (S)-4-(2-Amino-2-carboxyethyl)imidazole; FEMA No. 3694; L-His; (S)-alpha-amino-1H-imidazole-4-propanoic acid; Histidinum; 4-(2-Amino-2-carboxyethyl)imidazole
| 法规与食品接触 | EU Flavoring substances FDA Substance added to food: FLAVOR ENHANCER, FLAVORING AGENT OR ADJUVANT, NUTRIENT SUPPLEMENT Flavoring Agents FLAVOURING_AGENT: Flavouring Agent No safety concern at current levels of intake when used as a flavouring agent TRS 928-JECFA 63/98 |
|---|---|
| GHS 通报统计 | 74.1% (237 / 320) |
| GHS 通报统计 | 74.1% (237 / 320) |
|---|---|
| 已通报的危害声明 | H302 (25.3%), H315 (25.9%), H319 (25.9%), H332 (25.3%) |
L-Histidine 的 CAS 号为 71-00-1，分子式 C6H9N3O2，分子量 155.07 g/mol。 UNII 4QD397987E; ChEBI 15971; InChIKey HNDVDQJCIGZPNO-YFKPBYRVSA-N. Melting Point: 287; Melting Point: 287 °C (decomp); Melting Point: 287 °C.
数据来源：PubChem / Wikidata；与随货 COA 不一致时以 COA 为准。
English page: L-Histidine