Istradefylline

Independent reference data for Istradefylline (CAS 155270-99-8), compiled from public chemistry databases.

Registry identifiers across databases

Computed descriptors

Physicochemical values on record

Documented uses on record

Istradefylline is indicated in adjunct to levodopa and carbidopa in the treatment of Parkinson's disease.Istradefylline is an adenosine receptor antagonist that is used as adjunctive therapy to levodopa/carbidopa in patients with Parkinson disease experiencing difficulty with “off” episodes when motor symptoms breakthrough on treatment. Istradefylline has been associated with a low rate of serum enzyme elevations during therapy, but has not been linked to cases of clinically apparent liver injury with jaundice.

Synonyms and trade names

Istradefylline; 155270-99-8; KW-6002; nouriast; Nourianz; KW 6002; 8-[(E)-2-(3,4-dimethoxyphenyl)ethenyl]-1,3-diethyl-7-methylpurine-2,6-dione; istradefilina; DTXSID7057652; 2GZ0LIK7T4; (E)-8-(3,4-Dimethoxystyryl)-1,3-diethyl-7-methyl-3,7-dihydro-1H-purine-2,6-dione; DTXCID8031441; istradefyllinum; 8-((E)-2-(3,4-dimethoxyphenyl)ethenyl)-1,3-diethyl-7-methylpurine-2,6-dione; RefChem:57357; 8-(2-(3,4-dimethoxyphenyl)ethenyl)-1,3-diethyl-3,7-dihydro-7-methyl-1H-purine-2,6-dione

GHS hazard classification

Reported hazard statements	H301 (97.4%)

H301 (97.4%): Toxic if swallowed [Danger Acute toxicity, oral]

P264, P270, P301+P316, P321, P330, P405, and P501 (click each P-code to see the statement)

What the public record says

Istradefylline · CAS 155270-99-8 · C20H24N4O4. UNII 2GZ0LIK7T4. Boiling Point: 601; Melting Point: 189-193; Solubility: 0.5µg/mL.

Physical description and handling notes

Source: PubChem / Wikidata; the batch COA governs where values differ.