fluticasone (CAS 90566-53-3) — formula C22H27F3O4S, molecular weight 444.5; category organic chemicals.
| CAS Number | 90566-53-3 |
|---|---|
| Molecular Formula | C22H27F3O4S |
| Molecular Weight | 444.5 |
| LogP | 3.2 |
| Applications | Uses: Relieve inflammatory and pruritic symptoms of dermatoses and psoriases, intranasally to manage symptoms of allergic and non-allergic rhinitis, and orally for the treatment of asthma, Fluticasone propionate, Fluticasone propionate is claimed to exert a topical effect on the lungs without significant systemic effects, due to its low systemic bioavailability., THERAP CAT: Antiallergic, antiasthmatic, anti-inflammatory, Medication, Use (kg, approx.) in Germany (2009): >75, Consumption (g per capita, approx.) in Germany (2009): 0.000916, Calculated removal (%): 2, Impurities: 6alpha, 9-difluoro-11beta-hydroxy-16alpha-methyl-3-oxo-17-propanoyloxy)androsta-1, 4-diene-17beta-carboxylic acid, [(6alpha, 9-difluoro-11beta-hydroxy-16alpha-methyl-3-oxo-17-(propanoyloxy)androsta-1, 4-dien-17beta-yl]carbonyl]sulphenic acid, 6alpha, 9-difluoro-17-[[(fluoromethyl)sulpanyl]carbonyl]-11beta-hydroxy-16alpha-methyl-3-oxoandrosta-1, 4-dien-17alpha-yl acetate, 9-difluoro-17-[(methylsulphanyl)carbonyl]-11beta-hydroxy-16alpha-methyl-3-oxoandrosta-1, 4-dien-17alpha-yl propanoate, For more Impurities (Complete) data for Fluticasone (9 total), please visit the HSDB record page., Formulations, Preparations: Fluticasone propionate nasal spray is an aqueous suspension of microfine fluticasone propionate for topical administration to the nasal mucosa by means of a metering, atomizing spray pump. Fluticasone propionate nasal spray also contains microcrystalline cellulose and carboxymethylcellulose sodium, dextrose, 0.02% w, w benzalkonium chloride, polysorbate 80, and 0.25% w, w phenylethyl alcohol, and has a pH between 5 and 7., Each gram of fluticasone propionate cream contains fluticasone propionate 0.5 mg in a base of propylene glycol, mineral oil, cetostearyl alcohol, Ceteth-20, isopropyl myristate, dibasic sodium phosphate, citric acid, purified water, and imidurea as preservative., Each gram of fluticasone propionate ointment contains fluticasone propionate 0.05 mg in a base of liquid paraffin, microcrystalline wax, propylene glycol, and sorbitan sesquioleate., Fluticasone propionate Diskus is a specially designed plastic inhalation delivery system containing a double-foil blister strip of a powder formulation of fluticasone propionate intended for oral inhalation only. The Diskus inhalation unit, which is the delivery component, is an integral part of the drug product. Each blister on the double-foil strip within the unit contains 50 mcg of microfine fluticasone propionate in 12.5 mg of formulation containing lactose (which contains milk proteins)., Fluticasone propionate HFA inhalation aerosols (44, 110, 220 ug) are pressurized metered-dose aerosol units fitted with a counter. ... Each unit contains a microcrystalline suspension of fluticasone propionate (micronized) in propellant HFA-134a (1, 1, 2-tetrafluoroethane). It contains no other excipients., General Manufacturing Information: Medium-potency synthetic corticosteroid |
| Category | Organic Chemicals |
Documented applications: Uses: Relieve inflammatory and pruritic symptoms of dermatoses and psoriases, intranasally to manage symptoms of allergic and non-allergic rhinitis, and orally for the treatment of asthma, Fluticasone propionate, Fluticasone propionate is claimed to exert a topical effect on the lungs without significant systemic effects, due to its low systemic bioavailability., THERAP CAT: Antiallergic, antiasthmatic, anti-inflammatory, Medication, Use (kg, approx.) in Germany (2009): >75, Consumption (g per capita, approx.) in Germany (2009): 0.000916, Calculated removal (%): 2, Impurities: 6alpha, 9-difluoro-11beta-hydroxy-16alpha-methyl-3-oxo-17-propanoyloxy)androsta-1, 4-diene-17beta-carboxylic acid, [(6alpha, 9-difluoro-11beta-hydroxy-16alpha-methyl-3-oxo-17-(propanoyloxy)androsta-1, 4-dien-17beta-yl]carbonyl]sulphenic acid, 6alpha, 9-difluoro-17-[[(fluoromethyl)sulpanyl]carbonyl]-11beta-hydroxy-16alpha-methyl-3-oxoandrosta-1, 4-dien-17alpha-yl acetate, 9-difluoro-17-[(methylsulphanyl)carbonyl]-11beta-hydroxy-16alpha-methyl-3-oxoandrosta-1, 4-dien-17alpha-yl propanoate, For more Impurities (Complete) data for Fluticasone (9 total), please visit the HSDB record page., Formulations, Preparations: Fluticasone propionate nasal spray is an aqueous suspension of microfine fluticasone propionate for topical administration to the nasal mucosa by means of a metering, atomizing spray pump. Fluticasone propionate nasal spray also contains microcrystalline cellulose and carboxymethylcellulose sodium, dextrose, 0.02% w, w benzalkonium chloride, polysorbate 80, and 0.25% w, w phenylethyl alcohol, and has a pH between 5 and 7., Each gram of fluticasone propionate cream contains fluticasone propionate 0.5 mg in a base of propylene glycol, mineral oil, cetostearyl alcohol, Ceteth-20, isopropyl myristate, dibasic sodium phosphate, citric acid, purified water, and imidurea as preservative., Each gram of fluticasone propionate ointment contains fluticasone propionate 0.05 mg in a base of liquid paraffin, microcrystalline wax, propylene glycol, and sorbitan sesquioleate., Fluticasone propionate Diskus is a specially designed plastic inhalation delivery system containing a double-foil blister strip of a powder formulation of fluticasone propionate intended for oral inhalation only. The Diskus inhalation unit, which is the delivery component, is an integral part of the drug product. Each blister on the double-foil strip within the unit contains 50 mcg of microfine fluticasone propionate in 12.5 mg of formulation containing lactose (which contains milk proteins)., Fluticasone propionate HFA inhalation aerosols (44, 110, 220 ug) are pressurized metered-dose aerosol units fitted with a counter. ... Each unit contains a microcrystalline suspension of fluticasone propionate (micronized) in propellant HFA-134a (1, 1, 2-tetrafluoroethane). It contains no other excipients., General Manufacturing Information: Medium-potency synthetic corticosteroid.
fluticasone is a carbon-based organic compound with CAS registry number 90566-53-3 and molecular formula C22H27F3O4S (molecular weight 444.5), belonging to the organic chemicals segment of chemical raw materials.
CAS number: 90566-53-3
Its molecular formula C22H27F3O4S comprises 22 C, 27 H, 3 F, 4 O, 1 S atoms.
Also known as: fluticasone · 氟替卡松
Category: organic chemicals
The CAS registry number of fluticasone is 90566-53-3.
Molecular formula C22H27F3O4S, molecular weight 444.5.
It is also registered under: fluticasone, 氟替卡松.
Recorded applications: Uses: Relieve inflammatory and pruritic symptoms of dermatoses and psoriases, intranasally to manage symptoms of allergic and non-allergic rhinitis, and orally for the treatment of asthma, Fluticasone propionate, Fluticasone propionate is claimed to exert a topical effect on the lungs without significant systemic effects, due to its low systemic bioavailability., THERAP CAT: Antiallergic, antiasthmatic, anti-inflammatory, Medication, Use (kg, approx.) in Germany (2009): >75, Consumption (g per capita, approx.) in Germany (2009): 0.000916, Calculated removal (%): 2, Impurities: 6alpha, 9-difluoro-11beta-hydroxy-16alpha-methyl-3-oxo-17-propanoyloxy)androsta-1, 4-diene-17beta-carboxylic acid, [(6alpha, 9-difluoro-11beta-hydroxy-16alpha-methyl-3-oxo-17-(propanoyloxy)androsta-1, 4-dien-17beta-yl]carbonyl]sulphenic acid, 6alpha, 9-difluoro-17-[[(fluoromethyl)sulpanyl]carbonyl]-11beta-hydroxy-16alpha-methyl-3-oxoandrosta-1, 4-dien-17alpha-yl acetate, 9-difluoro-17-[(methylsulphanyl)carbonyl]-11beta-hydroxy-16alpha-methyl-3-oxoandrosta-1, 4-dien-17alpha-yl propanoate, For more Impurities (Complete) data for Fluticasone (9 total), please visit the HSDB record page., Formulations, Preparations: Fluticasone propionate nasal spray is an aqueous suspension of microfine fluticasone propionate for topical administration to the nasal mucosa by means of a metering, atomizing spray pump. Fluticasone propionate nasal spray also contains microcrystalline cellulose and carboxymethylcellulose sodium, dextrose, 0.02% w, w benzalkonium chloride, polysorbate 80, and 0.25% w, w phenylethyl alcohol, and has a pH between 5 and 7., Each gram of fluticasone propionate cream contains fluticasone propionate 0.5 mg in a base of propylene glycol, mineral oil, cetostearyl alcohol, Ceteth-20, isopropyl myristate, dibasic sodium phosphate, citric acid, purified water, and imidurea as preservative., Each gram of fluticasone propionate ointment contains fluticasone propionate 0.05 mg in a base of liquid paraffin, microcrystalline wax, propylene glycol, and sorbitan sesquioleate., Fluticasone propionate Diskus is a specially designed plastic inhalation delivery system containing a double-foil blister strip of a powder formulation of fluticasone propionate intended for oral inhalation only. The Diskus inhalation unit, which is the delivery component, is an integral part of the drug product. Each blister on the double-foil strip within the unit contains 50 mcg of microfine fluticasone propionate in 12.5 mg of formulation containing lactose (which contains milk proteins)., Fluticasone propionate HFA inhalation aerosols (44, 110, 220 ug) are pressurized metered-dose aerosol units fitted with a counter. ... Each unit contains a microcrystalline suspension of fluticasone propionate (micronized) in propellant HFA-134a (1, 1, 2-tetrafluoroethane). It contains no other excipients., General Manufacturing Information: Medium-potency synthetic corticosteroid.
Category: Organic Chemicals.
Independent reference data for fluticasone (CAS 90566-53-3), compiled from public chemistry databases.
| CAS Registry Number | 90566-53-3 |
|---|---|
| PubChem CID | 5311101 |
| Molecular formula | C22H27F3O4S |
| IUPAC name | S-(fluoromethyl) (6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-difluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthrene-17-carbothioate |
| UNII (FDA) | CUT2W21N7U |
| Molecular Weight | 444.5 |
|---|---|
| XLogP3 | 3.2 |
| Hydrogen Bond Donor Count | 2 |
| Hydrogen Bond Acceptor Count | 8 |
| Rotatable Bond Count | 3 |
| Exact Mass | 444.15821500 |
| Monoisotopic Mass | 444.15821500 |
| Topological Polar Surface Area | 99.9 |
| Heavy Atom Count | 30 |
fluticasone; 90566-53-3; Fluticasona; Fluticasonum; Fluticaps; Optinose; CUT2W21N7U; Opn-375; CHEBI:5134; DTXSID0044022; HFA, Flovent; Propionate, Fluticasone; RefChem:55221; DTXCID60820064; Flunase; Fluticaps (TN)
| Reported hazard statements | H302 (100%), H312 (100%), H315 (100%), H319 (100%), H332 (100%) |
|---|
H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
H312 (100%): Harmful in contact with skin [Warning Acute toxicity, dermal]
fluticasone · CAS 90566-53-3 · C22H27F3O4S. UNII CUT2W21N7U.
Source: PubChem / Wikidata; the batch COA governs where values differ.
Supplier: Jinan Shenghe Chemical Co., Ltd.
中文页面: 氟替卡松