氟替卡松（CAS 90566-53-3）：分子式 C22H27F3O4S、分子量 444.5。
| CAS号 | 90566-53-3 |
|---|---|
| 分子式 | C22H27F3O4S |
| 分子量 | 444.5 |
| LogP | 3.2 |
| 应用领域 | Uses: Relieve inflammatory and pruritic symptoms of dermatoses and psoriases、intranasally to manage symptoms of allergic and non-allergic rhinitis、and orally for the treatment of asthma、Fluticasone propionate、Fluticasone propionate is claimed to exert a topical effect on the lungs without significant systemic effects、due to its low systemic bioavailability.、THERAP CAT: Antiallergic、antiasthmatic、anti-inflammatory、Medication、Use (kg、approx.) in Germany (2009): >75、Consumption (g per capita、approx.) in Germany (2009): 0.000916、Calculated removal (%): 2、Impurities: 6alpha、9-difluoro-11beta-hydroxy-16alpha-methyl-3-oxo-17-propanoyloxy)androsta-1、4-diene-17beta-carboxylic acid、[(6alpha、9-difluoro-11beta-hydroxy-16alpha-methyl-3-oxo-17-(propanoyloxy)androsta-1、4-dien-17beta-yl]carbonyl]sulphenic acid、6alpha、9-difluoro-17-[[(fluoromethyl)sulpanyl]carbonyl]-11beta-hydroxy-16alpha-methyl-3-oxoandrosta-1、4-dien-17alpha-yl acetate、9-difluoro-17-[(methylsulphanyl)carbonyl]-11beta-hydroxy-16alpha-methyl-3-oxoandrosta-1、4-dien-17alpha-yl propanoate、For more Impurities (Complete) data for Fluticasone (9 total)、please visit the HSDB record page.、Formulations、Preparations: Fluticasone propionate nasal spray is an aqueous suspension of microfine fluticasone propionate for topical administration to the nasal mucosa by means of a metering、atomizing spray pump. Fluticasone propionate nasal spray also contains microcrystalline cellulose and carboxymethylcellulose sodium、dextrose、0.02% w、w benzalkonium chloride、polysorbate 80、and 0.25% w、w phenylethyl alcohol、and has a pH between 5 and 7.、Each gram of fluticasone propionate cream contains fluticasone propionate 0.5 mg in a base of propylene glycol、mineral oil、cetostearyl alcohol、Ceteth-20、isopropyl myristate、dibasic sodium phosphate、citric acid、purified water、and imidurea as preservative.、Each gram of fluticasone propionate ointment contains fluticasone propionate 0.05 mg in a base of liquid paraffin、microcrystalline wax、propylene glycol、and sorbitan sesquioleate.、Fluticasone propionate Diskus is a specially designed plastic inhalation delivery system containing a double-foil blister strip of a powder formulation of fluticasone propionate intended for oral inhalation only. The Diskus inhalation unit、which is the delivery component、is an integral part of the drug product. Each blister on the double-foil strip within the unit contains 50 mcg of microfine fluticasone propionate in 12.5 mg of formulation containing lactose (which contains milk proteins).、Fluticasone propionate HFA inhalation aerosols (44、110、220 ug) are pressurized metered-dose aerosol units fitted with a counter. ... Each unit contains a microcrystalline suspension of fluticasone propionate (micronized) in propellant HFA-134a (1、1、2-tetrafluoroethane). It contains no other excipients.、General Manufacturing Information: Medium-potency synthetic corticosteroid |
登记用途：Uses: Relieve inflammatory and pruritic symptoms of dermatoses and psoriases、intranasally to manage symptoms of allergic and non-allergic rhinitis、and orally for the treatment of asthma、Fluticasone propionate、Fluticasone propionate is claimed to exert a topical effect on the lungs without significant systemic effects、due to its low systemic bioavailability.、THERAP CAT: Antiallergic、antiasthmatic、anti-inflammatory、Medication、Use (kg、approx.) in Germany (2009): >75、Consumption (g per capita、approx.) in Germany (2009): 0.000916、Calculated removal (%): 2、Impurities: 6alpha、9-difluoro-11beta-hydroxy-16alpha-methyl-3-oxo-17-propanoyloxy)androsta-1、4-diene-17beta-carboxylic acid、[(6alpha、9-difluoro-11beta-hydroxy-16alpha-methyl-3-oxo-17-(propanoyloxy)androsta-1、4-dien-17beta-yl]carbonyl]sulphenic acid、6alpha、9-difluoro-17-[[(fluoromethyl)sulpanyl]carbonyl]-11beta-hydroxy-16alpha-methyl-3-oxoandrosta-1、4-dien-17alpha-yl acetate、9-difluoro-17-[(methylsulphanyl)carbonyl]-11beta-hydroxy-16alpha-methyl-3-oxoandrosta-1、4-dien-17alpha-yl propanoate、For more Impurities (Complete) data for Fluticasone (9 total)、please visit the HSDB record page.、Formulations、Preparations: Fluticasone propionate nasal spray is an aqueous suspension of microfine fluticasone propionate for topical administration to the nasal mucosa by means of a metering、atomizing spray pump. Fluticasone propionate nasal spray also contains microcrystalline cellulose and carboxymethylcellulose sodium、dextrose、0.02% w、w benzalkonium chloride、polysorbate 80、and 0.25% w、w phenylethyl alcohol、and has a pH between 5 and 7.、Each gram of fluticasone propionate cream contains fluticasone propionate 0.5 mg in a base of propylene glycol、mineral oil、cetostearyl alcohol、Ceteth-20、isopropyl myristate、dibasic sodium phosphate、citric acid、purified water、and imidurea as preservative.、Each gram of fluticasone propionate ointment contains fluticasone propionate 0.05 mg in a base of liquid paraffin、microcrystalline wax、propylene glycol、and sorbitan sesquioleate.、Fluticasone propionate Diskus is a specially designed plastic inhalation delivery system containing a double-foil blister strip of a powder formulation of fluticasone propionate intended for oral inhalation only. The Diskus inhalation unit、which is the delivery component、is an integral part of the drug product. Each blister on the double-foil strip within the unit contains 50 mcg of microfine fluticasone propionate in 12.5 mg of formulation containing lactose (which contains milk proteins).、Fluticasone propionate HFA inhalation aerosols (44、110、220 ug) are pressurized metered-dose aerosol units fitted with a counter. ... Each unit contains a microcrystalline suspension of fluticasone propionate (micronized) in propellant HFA-134a (1、1、2-tetrafluoroethane). It contains no other excipients.、General Manufacturing Information: Medium-potency synthetic corticosteroid。
氟替卡松 是一种化工化合物，登记 CAS 号为 90566-53-3，分子式 C22H27F3O4S（分子量 444.5）。
登记 CAS 号：90566-53-3
其分子式 C22H27F3O4S 由 22 个碳、27 个氢、3 个氟、4 个氧、1 个硫 组成。
别名/同义词：氟替卡松 · fluticasone
氟替卡松 的 CAS 登记号为 90566-53-3。
分子式 C22H27F3O4S，分子量 444.5。
别名/同义词：氟替卡松、fluticasone。
登记用途：Uses: Relieve inflammatory and pruritic symptoms of dermatoses and psoriases、intranasally to manage symptoms of allergic and non-allergic rhinitis、and orally for the treatment of asthma、Fluticasone propionate、Fluticasone propionate is claimed to exert a topical effect on the lungs without significant systemic effects、due to its low systemic bioavailability.、THERAP CAT: Antiallergic、antiasthmatic、anti-inflammatory、Medication、Use (kg、approx.) in Germany (2009): >75、Consumption (g per capita、approx.) in Germany (2009): 0.000916、Calculated removal (%): 2、Impurities: 6alpha、9-difluoro-11beta-hydroxy-16alpha-methyl-3-oxo-17-propanoyloxy)androsta-1、4-diene-17beta-carboxylic acid、[(6alpha、9-difluoro-11beta-hydroxy-16alpha-methyl-3-oxo-17-(propanoyloxy)androsta-1、4-dien-17beta-yl]carbonyl]sulphenic acid、6alpha、9-difluoro-17-[[(fluoromethyl)sulpanyl]carbonyl]-11beta-hydroxy-16alpha-methyl-3-oxoandrosta-1、4-dien-17alpha-yl acetate、9-difluoro-17-[(methylsulphanyl)carbonyl]-11beta-hydroxy-16alpha-methyl-3-oxoandrosta-1、4-dien-17alpha-yl propanoate、For more Impurities (Complete) data for Fluticasone (9 total)、please visit the HSDB record page.、Formulations、Preparations: Fluticasone propionate nasal spray is an aqueous suspension of microfine fluticasone propionate for topical administration to the nasal mucosa by means of a metering、atomizing spray pump. Fluticasone propionate nasal spray also contains microcrystalline cellulose and carboxymethylcellulose sodium、dextrose、0.02% w、w benzalkonium chloride、polysorbate 80、and 0.25% w、w phenylethyl alcohol、and has a pH between 5 and 7.、Each gram of fluticasone propionate cream contains fluticasone propionate 0.5 mg in a base of propylene glycol、mineral oil、cetostearyl alcohol、Ceteth-20、isopropyl myristate、dibasic sodium phosphate、citric acid、purified water、and imidurea as preservative.、Each gram of fluticasone propionate ointment contains fluticasone propionate 0.05 mg in a base of liquid paraffin、microcrystalline wax、propylene glycol、and sorbitan sesquioleate.、Fluticasone propionate Diskus is a specially designed plastic inhalation delivery system containing a double-foil blister strip of a powder formulation of fluticasone propionate intended for oral inhalation only. The Diskus inhalation unit、which is the delivery component、is an integral part of the drug product. Each blister on the double-foil strip within the unit contains 50 mcg of microfine fluticasone propionate in 12.5 mg of formulation containing lactose (which contains milk proteins).、Fluticasone propionate HFA inhalation aerosols (44、110、220 ug) are pressurized metered-dose aerosol units fitted with a counter. ... Each unit contains a microcrystalline suspension of fluticasone propionate (micronized) in propellant HFA-134a (1、1、2-tetrafluoroethane). It contains no other excipients.、General Manufacturing Information: Medium-potency synthetic corticosteroid。
氟替卡松（CAS 90566-53-3）的独立参考数据，整理自公开化学数据库。
| CAS Registry Number | 90566-53-3 |
|---|---|
| PubChem CID | 5311101 |
| Molecular formula | C22H27F3O4S |
| IUPAC name | S-(fluoromethyl) (6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-difluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthrene-17-carbothioate |
| UNII (FDA) | CUT2W21N7U |
| Molecular Weight | 444.5 |
|---|---|
| XLogP3 | 3.2 |
| Hydrogen Bond Donor Count | 2 |
| Hydrogen Bond Acceptor Count | 8 |
| Rotatable Bond Count | 3 |
| Exact Mass | 444.15821500 |
| Monoisotopic Mass | 444.15821500 |
| Topological Polar Surface Area | 99.9 |
| Heavy Atom Count | 30 |
fluticasone; 90566-53-3; Fluticasona; Fluticasonum; Fluticaps; Optinose; CUT2W21N7U; Opn-375; CHEBI:5134; DTXSID0044022; HFA, Flovent; Propionate, Fluticasone; RefChem:55221; DTXCID60820064; Flunase; Fluticaps (TN)
| Reported hazard statements | H302 (100%), H312 (100%), H315 (100%), H319 (100%), H332 (100%) |
|---|
H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
H312 (100%): Harmful in contact with skin [Warning Acute toxicity, dermal]
fluticasone · CAS 90566-53-3 · C22H27F3O4S. UNII CUT2W21N7U.
数据来源：PubChem / Wikidata；与随货 COA 不一致时以 COA 为准。
English page: fluticasone