环己基氨基磺酸

环己基氨基磺酸（CAS 100-88-9）：分子式 C6H13NO3S、分子量 179.24；类别 甜味剂。

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应用领域

登记用途：Uses: Used as intermediate for its salts (non-caloric sweeteners)、Used formerly as non-nutritive sweetener、[HSDB] Used as acidulant、[Hawley]、Non-nutritive sweetener、Acidulant、Sodium and calcium cyclamates are used as non-nutritive sweeteners ... Calcium cyclamate is used in low-sodium and sodium-free products、Cyclamate salts、CHEM INT FOR SALTS (NONCALORIC SWEETENERS)、The main application of cyclamates ... is in blends with saccharin in a 10:1 ratio by weight. In these blends、quantitative and qualitative synergistic effects can be used to advantage、rendering them an important sweetener system in countries approving the use of both sweeteners.、Use Classification: Food Additives -> SWEETENER -> JECFA Functional Classes、Food Additives -> SWEETENER -> JECFA Functional Classes、Industry Uses: Cleaning agent、Consumer Uses: Cleaning agent、Methods of Manufacturing: The starting material for cyclamate production is cyclohexylamine、which is reacted with sulfonating agents. The originally used chlorosulfonic acid has been replaced by other compounds. In high-boiling-point solvents、cyclohexylamine reacts with sulfamic acid to N-cyclohexyl-N-cyclohexylammonium sulfamate. Reaction with sodium or calcium hydroxide yields cyclamates and free cyclohexylamine. In a corresponding way、equimolar amounts of cyclohexylamine and tertiary amines react to trialkylammonium-N-cyclohexyl sulfamates、the respective cyclamates being formed after reaction with sodium or calcium hydroxide.、Cyclamic acid was synthesized by the reaction of barium-N-cyclohexylsulphamate (made by the sulphonation of cyclohexylamine with chlorosulphonic acid in chloroform followed by treatment with barium hydroxide) with sulphuric acid.、Sodium cyclamate was synthesized ... by the sulfonation of cyclohexylamine with chlorosulfonic acid in chloroform to produce cyclohexylammonium N-cyclohexylsulfamate、which was then treated with sodium hydroxide. Sodium cyclamate has also been made by the reaction of nitrocyclohexane with sodium dithionite in aqueous solution in the presence of trisodium phosphate.、Sodium cyclamate、By neutralizing cyclamic acid with ... calcium hydroxide ... or by sulfonation of cyclohexylamine with ... calcium sulfamate.、Calcium cyclamate、Formulations、Preparations: SODIUM AND CALCIUM CYCLAMATES WERE USED MAINLY IN THE FORM OF THE 10:1 CYCLAMATE:SACCHARIN SALT MIXT.、NA & CA SALT、Grades: NF、National Formulary、FCC、Food Chem Codex、NRC、.、Sodium salt、In the US、cyclamic acid is available with a minimum purity of 98% on an anhydrous basis、In the USA、calcium cyclamate was available commercially in 1970 as a US National Formulary (NF) grade crystalline powder containing 98-101% active ingredient on an anhydrous basis、6-9% water、a maximum of 30 mg、kg selenium、25 mg、kg cyclohexylamine、10 mg、kg heavy metals and 3 mg、kg arsenic. It was also available in: (1) aqueous solutions containing about 6% calcium cyclamate combined with about 0.6% calcium saccharin、and (2) tablets containing about 50 mg calcium cyclamate combined with about 5 mg calcium saccharin.、Trade names: Cyclan、Cylan、Dietil、Sucaryl Calcium.、Consumption Patterns: SALE OF BEVERAGES CONTAINING CYCLAMATES WAS PROHIBITED BY US FOOD & DRUG ADMINISTRATION ON JANUARY 1、1970、AND SALE OF OTHER FOOD PRODUCTS CONTAINING CYCLAMATES WAS PROHIBITED ON SEPTEMBER 1、1970 (1970)、Global consumption (1000 tons): 47、100% as a chemical intended for its salts (sale of beverages containing cyclamates was prohibited by US Food & Drug Administration on January 1、and sale of other food products containing cyclamates was prohibited on September 1、1970) (1977)、THE US CONSUMPTION PATTERN FOR ALL 3 FORMS OF CYCLAMATES IN 1965 WAS AS FOLLOWS: 53% IN CARBONATED BEVERAGES、17% IN DRY BEVERAGE BASES、13% IN DIET FOODS、12% IN SWEETENER FORMULATIONS...& 5 IN MISCELLANEOUS APPLICATIONS...、U.S. Production: 2023: 276、787 lb、2022: 276、(1972) PROBABLY GREATER THAN 4.54X10+5 GRAMS、(1975) PROBABLY GREATER THAN 4.54X10+5 GRAMS、Production volumes for non-confidential chemicals reported under the Inventory Update Rule. [Table#961]、General Manufacturing Information: Soap、Cleaning Compound、and Toilet Preparation Manufacturing、Sulfamic acid、N-cyclohexyl-: ACTIVE、Group name for synthetic nonnutritive sweetening agents derived from cyclohexylamine or cyclamic acid. The series includes sodium、potassium、and calcium cyclamates. As a result of a study made on laboratory animals in 1970、which indicated that these compounds cause genetic damage in chick embryos and cancer in rats at high dosage、their use in beverages and food products was banned in the U.S. More recent research has failed to confirm the carcinogenicity of these compounds in laboratory animals even at levels up to 240 times human intake. Notwithstanding these results、FDA has not yet withdrawn its ban on use of cyclamates as food additives or as table-top sweeteners、in view of the continuing uncertainty about their safety.、Cyclamate was banned in the United States in 1970、Cyclamate is allowed for use in any or all three categories、ie food、beverage、and tabletop、in approximately 50 countries. In 2004、the maximum beverage use level ... in the European Union was lowered to 250 ppm (as cyclamic acid). Sweet n' Low、known in the US as a saccharin-based tabletop sweetener、contains exclusively cyclamate in Canada.、... Sweetening effect of 125 mg approx equiv to 1 teaspoonful of sugar ...、For more General Manufacturing Information (Complete) data for CYCLAMATE (8 total)、please visit the HSDB record page.。

技术档案

这个产品是什么

环己基氨基磺酸 是一种化工化合物，登记 CAS 号为 100-88-9，分子式 C6H13NO3S（分子量 179.24），归属于甜味剂大类化工原料。

识别信息

登记 CAS 号：100-88-9

其分子式 C6H13NO3S 由 6 个碳、13 个氢、1 个氮、3 个氧、1 个硫 组成。

别名/同义词：环己基氨基磺酸 · Cyclamic Acid

所属分类：甜味剂

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