Ciguatoxin (CAS 11050-21-8) — formula C60H86O19, molecular weight 1111.3; category organic chemicals.
| CAS Number | 11050-21-8 |
|---|---|
| Molecular Formula | C60H86O19 |
| Molecular Weight | 1111.3 |
| LogP | 2.5 |
| Applications | Uses: A toxin found in a variety of fish produced by the dinoflagellate Gambierdiscus spp, [Merck Index], It is a marine toxin, found in reef fish (L994)., General Manufacturing Information: Ciguatoxin and maitotoxin have been isolated from the biodetritus layer of coral reefs, from the dinoflagellate Gambierdiscus toxicus collected from seawater, and from axenic cultures of G. toxicus., Family of lipid soluble polyether toxins responsible for ciguatera food poisoning, structural variations are associated with the oceanic region from which the dinoflagellate originates., Ciguatoxins, Toxin profiles of representative ciguatera species caught at different locations of Japan were investigated in fish flesh by high-performance liquid chromatography tandem mass spectrometry (LC-MS, MS) analysis. Identification and quantification of 16 toxins were facilitated by the use of 14 reference toxins prepared by either synthesis or isolation from natural sources and the previous LC-MS data thereof. Sodium adduct ions [M + Na]+ were used as parent and product ions. Distinct regional differences were unveiled: ciguatoxin-1B type toxins were found in snappers and groupers from Okinawa, ciguatoxin-3C type toxins were found in a spotted knifejaw, Oplegnathus punctatus, from Miyazaki located 730 km north of Okinawa, and both types of toxins were found in a red snapper, Lutjanus bohar, from Minamitorishima (Marcus) Island. Twelve toxins were identified in a dinoflagellate, Gambierdiscus toxicus, collected as the primary toxin source in French Polynesia. Occurrence of M-seco-toxins in fish and oxidized toxins in the dinoflagellate was confirmed for the first time. The present LC-MS, MS method is rapid, specific, and accurate. It not only outperforms the currently employed mouse bioassays but also enables the study of the toxin dynamics during the food chain transmission. |
| Category | Organic Chemicals |
Documented applications: Uses: A toxin found in a variety of fish produced by the dinoflagellate Gambierdiscus spp, [Merck Index], It is a marine toxin, found in reef fish (L994)., General Manufacturing Information: Ciguatoxin and maitotoxin have been isolated from the biodetritus layer of coral reefs, from the dinoflagellate Gambierdiscus toxicus collected from seawater, and from axenic cultures of G. toxicus., Family of lipid soluble polyether toxins responsible for ciguatera food poisoning, structural variations are associated with the oceanic region from which the dinoflagellate originates., Ciguatoxins, Toxin profiles of representative ciguatera species caught at different locations of Japan were investigated in fish flesh by high-performance liquid chromatography tandem mass spectrometry (LC-MS, MS) analysis. Identification and quantification of 16 toxins were facilitated by the use of 14 reference toxins prepared by either synthesis or isolation from natural sources and the previous LC-MS data thereof. Sodium adduct ions [M + Na]+ were used as parent and product ions. Distinct regional differences were unveiled: ciguatoxin-1B type toxins were found in snappers and groupers from Okinawa, ciguatoxin-3C type toxins were found in a spotted knifejaw, Oplegnathus punctatus, from Miyazaki located 730 km north of Okinawa, and both types of toxins were found in a red snapper, Lutjanus bohar, from Minamitorishima (Marcus) Island. Twelve toxins were identified in a dinoflagellate, Gambierdiscus toxicus, collected as the primary toxin source in French Polynesia. Occurrence of M-seco-toxins in fish and oxidized toxins in the dinoflagellate was confirmed for the first time. The present LC-MS, MS method is rapid, specific, and accurate. It not only outperforms the currently employed mouse bioassays but also enables the study of the toxin dynamics during the food chain transmission..
Ciguatoxin is a carbon-based organic compound with CAS registry number 11050-21-8 and molecular formula C60H86O19 (molecular weight 1111.3), belonging to the organic chemicals segment of chemical raw materials.
CAS number: 11050-21-8
Its molecular formula C60H86O19 comprises 60 C, 86 H, 19 O atoms.
Also known as: Ciguatoxin · 雪卡毒素
Category: organic chemicals
The CAS registry number of Ciguatoxin is 11050-21-8.
Molecular formula C60H86O19, molecular weight 1111.3.
It is also registered under: Ciguatoxin, 雪卡毒素.
Recorded applications: Uses: A toxin found in a variety of fish produced by the dinoflagellate Gambierdiscus spp, [Merck Index], It is a marine toxin, found in reef fish (L994)., General Manufacturing Information: Ciguatoxin and maitotoxin have been isolated from the biodetritus layer of coral reefs, from the dinoflagellate Gambierdiscus toxicus collected from seawater, and from axenic cultures of G. toxicus., Family of lipid soluble polyether toxins responsible for ciguatera food poisoning, structural variations are associated with the oceanic region from which the dinoflagellate originates., Ciguatoxins, Toxin profiles of representative ciguatera species caught at different locations of Japan were investigated in fish flesh by high-performance liquid chromatography tandem mass spectrometry (LC-MS, MS) analysis. Identification and quantification of 16 toxins were facilitated by the use of 14 reference toxins prepared by either synthesis or isolation from natural sources and the previous LC-MS data thereof. Sodium adduct ions [M + Na]+ were used as parent and product ions. Distinct regional differences were unveiled: ciguatoxin-1B type toxins were found in snappers and groupers from Okinawa, ciguatoxin-3C type toxins were found in a spotted knifejaw, Oplegnathus punctatus, from Miyazaki located 730 km north of Okinawa, and both types of toxins were found in a red snapper, Lutjanus bohar, from Minamitorishima (Marcus) Island. Twelve toxins were identified in a dinoflagellate, Gambierdiscus toxicus, collected as the primary toxin source in French Polynesia. Occurrence of M-seco-toxins in fish and oxidized toxins in the dinoflagellate was confirmed for the first time. The present LC-MS, MS method is rapid, specific, and accurate. It not only outperforms the currently employed mouse bioassays but also enables the study of the toxin dynamics during the food chain transmission..
Category: Organic Chemicals.
Independent reference data for Ciguatoxin (CAS 11050-21-8), compiled from public chemistry databases.
| CAS 号 | 11050-21-8 |
|---|---|
| PubChem CID | 5311333 |
| 分子式 | C60H86O19 |
| UNII（FDA） | 2UKQ3B7696 |
| Molecular Weight | 1111.3 |
|---|---|
| XLogP3 | 2.5 |
| Hydrogen Bond Donor Count | 6 |
| Hydrogen Bond Acceptor Count | 19 |
| Rotatable Bond Count | 3 |
| Exact Mass | 1110.57633051 |
| Monoisotopic Mass | 1110.57633051 |
| Topological Polar Surface Area | 241 |
| Heavy Atom Count | 79 |
Ciguatoxin CTX 1; CIGUATOXIN; 11050-21-8; Ciguatoxins; Ciguatoxin 1; CTX 1; P-CTX 1; 2UKQ3B7696; DTXSID40880000; RefChem:388885; CHEBI:61275; DTXCID401763388; CTX-1; Pacific ciguatoxin 1; ciguatoxin-1; Ciguatoxin I
雪卡毒素 · CAS 11050-21-8 · C60H86O19. UNII 2UKQ3B7696.
Source: PubChem / Wikidata; the batch COA governs where values differ.
Supplier: Jinan Shenghe Chemical Co., Ltd.
中文页面: 雪卡毒素