(+-)-Cephalothin (CAS 51098-29-4) — formula C16H16N2O6S2, molecular weight 396.4; category organic chemicals.
| CAS Number | 51098-29-4 |
|---|---|
| Molecular Formula | C16H16N2O6S2 |
| Molecular Weight | 396.4 |
| Melting Point | 160-160.5 °C |
| LogP | -0.2 |
| Applications | Uses: Vet: Antibacterial ... usually quite active against many gram-positive bacteria ... moderately active against gram-negative bacteria ... relatively susceptible to beta-lactamases ... not as effetive against anaerobes as ... penicillins., First-generation cephalosporins, Mesh Heading: anti-bacterial agents, MEDICATION, MEDICATION (VET), Use Classification: Pharmaceuticals, Methods of Manufacturing: ... E. H. Flynn, US patent 3, 218, 318 (1965 to Lilly), French patent 1, 384, 197 (1965 to Glaxo)., REACTION OF 7-AMINOCEPHALOSPORANIC ACID WITH THIOPHENE ACETYL CHLORIDE IN ACETONE, 7-AMINOCEPHALOSPORANIC ACID IS N-ACETYLATED...WITH 2-THIOPHENEACETYL CHLORIDE IN...DEHYDROCHLORINATING ENVIRONMENT. STARTING ACID...PREPD FROM NATURAL ANTIBIOTIC, CEPHALOSPORIN C, BY EITHER PROTON-CATALYZED OR ENZYMATIC HYDROLYSIS. CEPHALOTHIN...CONVERTED TO SODIUM SALT BY INTERACTION WITH SODIUM ACETATE..., SODIUM, Formulations, Preparations: Sterile cephalothin sodium, USP (keflin), is marketed in 10-mL rubber-stoppered vials containing either 1, 2, or 4 g., Consumption Patterns: ESSENTIALLY 100% AS AN ANTIBIOTIC (AS SODIUM SALT), U.S. Production: (1977) PROBABLY GREATER THAN 4.54X10+5 GRAMS, (1979) PROBABLY GREATER THAN 4.5X10+5 G-SODIUM, General Manufacturing Information: Cephalothin is semisynthetic derivative of cephalosporin C ..., CEPHALOSPORINS ARE INCOMPATIBLE WITH ERYTHROMYCIN & TETRACYCLINES IN PARENTERAL MIXTURES., CEPHALOSPORINS, FROM TABLE, Cephalosporin C is very resistant to action of penicillinase, for which it is both competitive and noncompetitive inhibitor, depending on substrate tested ..., Cephalosporins |
| Category | Organic Chemicals |
Documented applications: Uses: Vet: Antibacterial ... usually quite active against many gram-positive bacteria ... moderately active against gram-negative bacteria ... relatively susceptible to beta-lactamases ... not as effetive against anaerobes as ... penicillins., First-generation cephalosporins, Mesh Heading: anti-bacterial agents, MEDICATION, MEDICATION (VET), Use Classification: Pharmaceuticals, Methods of Manufacturing: ... E. H. Flynn, US patent 3, 218, 318 (1965 to Lilly), French patent 1, 384, 197 (1965 to Glaxo)., REACTION OF 7-AMINOCEPHALOSPORANIC ACID WITH THIOPHENE ACETYL CHLORIDE IN ACETONE, 7-AMINOCEPHALOSPORANIC ACID IS N-ACETYLATED...WITH 2-THIOPHENEACETYL CHLORIDE IN...DEHYDROCHLORINATING ENVIRONMENT. STARTING ACID...PREPD FROM NATURAL ANTIBIOTIC, CEPHALOSPORIN C, BY EITHER PROTON-CATALYZED OR ENZYMATIC HYDROLYSIS. CEPHALOTHIN...CONVERTED TO SODIUM SALT BY INTERACTION WITH SODIUM ACETATE..., SODIUM, Formulations, Preparations: Sterile cephalothin sodium, USP (keflin), is marketed in 10-mL rubber-stoppered vials containing either 1, 2, or 4 g., Consumption Patterns: ESSENTIALLY 100% AS AN ANTIBIOTIC (AS SODIUM SALT), U.S. Production: (1977) PROBABLY GREATER THAN 4.54X10+5 GRAMS, (1979) PROBABLY GREATER THAN 4.5X10+5 G-SODIUM, General Manufacturing Information: Cephalothin is semisynthetic derivative of cephalosporin C ..., CEPHALOSPORINS ARE INCOMPATIBLE WITH ERYTHROMYCIN & TETRACYCLINES IN PARENTERAL MIXTURES., CEPHALOSPORINS, FROM TABLE, Cephalosporin C is very resistant to action of penicillinase, for which it is both competitive and noncompetitive inhibitor, depending on substrate tested ..., Cephalosporins.
(+-)-Cephalothin is a carbon-based organic compound with CAS registry number 51098-29-4 and molecular formula C16H16N2O6S2 (molecular weight 396.4), belonging to the organic chemicals segment of chemical raw materials.
CAS number: 51098-29-4
Its molecular formula C16H16N2O6S2 comprises 16 C, 16 H, 2 N, 6 O, 2 S atoms.
Also known as: (+-)-Cephalothin · (+-)-头孢噻吩
Category: organic chemicals
The CAS registry number of (+-)-Cephalothin is 51098-29-4.
Molecular formula C16H16N2O6S2, molecular weight 396.4.
It is also registered under: (+-)-Cephalothin, (+-)-头孢噻吩.
Recorded applications: Uses: Vet: Antibacterial ... usually quite active against many gram-positive bacteria ... moderately active against gram-negative bacteria ... relatively susceptible to beta-lactamases ... not as effetive against anaerobes as ... penicillins., First-generation cephalosporins, Mesh Heading: anti-bacterial agents, MEDICATION, MEDICATION (VET), Use Classification: Pharmaceuticals, Methods of Manufacturing: ... E. H. Flynn, US patent 3, 218, 318 (1965 to Lilly), French patent 1, 384, 197 (1965 to Glaxo)., REACTION OF 7-AMINOCEPHALOSPORANIC ACID WITH THIOPHENE ACETYL CHLORIDE IN ACETONE, 7-AMINOCEPHALOSPORANIC ACID IS N-ACETYLATED...WITH 2-THIOPHENEACETYL CHLORIDE IN...DEHYDROCHLORINATING ENVIRONMENT. STARTING ACID...PREPD FROM NATURAL ANTIBIOTIC, CEPHALOSPORIN C, BY EITHER PROTON-CATALYZED OR ENZYMATIC HYDROLYSIS. CEPHALOTHIN...CONVERTED TO SODIUM SALT BY INTERACTION WITH SODIUM ACETATE..., SODIUM, Formulations, Preparations: Sterile cephalothin sodium, USP (keflin), is marketed in 10-mL rubber-stoppered vials containing either 1, 2, or 4 g., Consumption Patterns: ESSENTIALLY 100% AS AN ANTIBIOTIC (AS SODIUM SALT), U.S. Production: (1977) PROBABLY GREATER THAN 4.54X10+5 GRAMS, (1979) PROBABLY GREATER THAN 4.5X10+5 G-SODIUM, General Manufacturing Information: Cephalothin is semisynthetic derivative of cephalosporin C ..., CEPHALOSPORINS ARE INCOMPATIBLE WITH ERYTHROMYCIN & TETRACYCLINES IN PARENTERAL MIXTURES., CEPHALOSPORINS, FROM TABLE, Cephalosporin C is very resistant to action of penicillinase, for which it is both competitive and noncompetitive inhibitor, depending on substrate tested ..., Cephalosporins.
Category: Organic Chemicals.
Independent reference data for (+-)-Cephalothin (CAS 51098-29-4), compiled from public chemistry databases.
| CAS 号 | 51098-29-4 |
|---|---|
| PubChem CID | 6024 |
| 分子式 | C16H16N2O6S2 |
| IUPAC 名称 | (6R,7R)-3-(acetyloxymethyl)-8-oxo-7-[(2-thiophen-2-ylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid |
| UNII（FDA） | R72LW146E6 |
| Molecular Weight | 396.4 |
|---|---|
| XLogP3 | -0.4 |
| Hydrogen Bond Donor Count | 2 |
| Hydrogen Bond Acceptor Count | 8 |
| Rotatable Bond Count | 7 |
| Exact Mass | 396.04497858 |
| Monoisotopic Mass | 396.04497858 |
| Topological Polar Surface Area | 167 |
| Heavy Atom Count | 26 |
| Melting Point | 160-160.5 °C |
|---|---|
| Melting Point | 160 - 160.5 °C |
| Solubility | 158 |
| Solubility | 5.21e-02 g/L |
| LogP | -0.2 |
cephalothin; Cefalotin; 153-61-7; Cephalotin; Cefalothin; Cephalothinum; Cefalotina; Cemastin; Cefalotine; Coaxin; Averon-1; Cefalotinum; 7-(2-Thienylacetamido)cephalosporanic acid; 7-(Thiophene-2-acetamido)cephalosporin; 7-(Thiophene-2-acetamido)cephalosporanic acid; DTXSID4022783
| 已通报的危害声明 | H317 (100%), H334 (100%) |
|---|
(+-)-头孢噻吩 · CAS 51098-29-4 · C16H16N2O6S2. UNII R72LW146E6. Melting Point: 160-160.5 °C; Melting Point: 160 - 160.5 °C; Solubility: 158.
Source: PubChem / Wikidata; the batch COA governs where values differ.
Supplier: Jinan Shenghe Chemical Co., Ltd.
中文页面: (+-)-头孢噻吩