L-天冬氨酸，L-天冬酸（CAS 56-84-8）：分子式 C4H7NO4、分子量 133.10；类别 食品添加剂。
| CAS号 | 56-84-8 |
|---|---|
| 分子式 | C4H7NO4 |
| 分子量 | 133.10 |
| 熔点 | 270 |
| LogP | -3.89 |
| 应用领域 | Uses: CIR ingredient: Aspartic Acid、A non-essential amino acid、[Merck Index] [REPROTOX] Used in biological and clinical studies、to make culture media、and in aspartame products (detergents、fungicides、germicides、and metal complexations)、[HSDB] Used in chemical synthesis、cosmetics、and pharmaceuticals、[IUCLID] Used as a flavoring agent and nutritional supplement、[FDA]、BIOLOGICAL & CLINICAL STUDIES、PREPN OF CULTURE MEDIA、ORG INTERMEDIATE、INGREDIENT OF ASPARTAME、DETERGENTS、FUNGICIDES、GERMICIDES、METAL COMPLEXATION、ASPARTIC ACID、Used in flavor reaction products and pharmaceuticals formulations and intermediates、Roborant、Used as a raw material in the synthesis of peptide drugs、For more Uses (Complete) data for (L)-ASPARTIC ACID (7 total)、please visit the HSDB record page.、Use (kg、approx.) in Germany (2009): >1000、Consumption (g per capita、approx.) in Germany (2009): 0.0122、Calculated removal (%): 92.1、Use Classification: Flavoring Agents -> JECFA Flavorings Index、Flavouring Agent -> FLAVOURING_AGENT -> JECFA Functional Classes、Cosmetics -> Antistatic、Industry Uses: Not Known or Reasonably Ascertainable、Intermediate、Chelating agent、Household Products: Information on 14 consumer products that contain Aspartic acid、disodium salt in the following categories is provided:、• Auto Products、• Commercial、Institutional、Information on 11 consumer products that contain Aspartic acid in the following categories is provided:、• Inside the Home、• Personal Care、Methods of Manufacturing: Hydrolysis of asparagine、reaction of ammonia with diethyl fumarate、L-Aspartic acid is industrially manufactured by an enzymatic process in which aspartase (l-aspartate ammonia lyase、EC 4.3.1.1) catalyzes the addition of ammonia to fumaric acid. Advantages of the enzymatic production method are higher product concentration and productivity and the formation of fewer byproducts. Thus、l-aspartic acid can be easily separated from the reaction mixture by crystallization.、In 1973、an immobilized cell system based on Escherichia coli cells entrapped in polyacrylamide gel lattice was introduced for large-scale production.、Formulations、Preparations: (VET) COMMERCIALLY AVAILABLE AS MIXT OF POTASSIUM & MAGNESIUM ASPARTATES= SPARTASE.、AVAILABLE COMMERCIALLY AS D(-)-、L(+)-、& DL-ASPARTIC ACID.、150 G ASPARTIC ACID WAS POLYMERIZED IN PRESENCE OF H3PO4 TO GIVE 150 G POLY(DEHYDROASPARTIC ACID) WHICH WAS TREATED WITH MORPHOLINE. POLYMER WAS INCORPORATED INTO AN ANIONIC SHAMPOO WITH 4% CONCN.、USP and FCC grades、99% min grade、U.S. Production: 2023: 50、000 - <75、000 lb、2022: 250、000 - <550、2021: 400、2020: 250、000 - <400、This chemical is listed as a High Production Volume (HPV) (65FR81686). Chemicals listed as HPV were produced in or imported into the U.S. in >1 million pounds in 1990 and、or 1994. The HPV list is based on the 1990 Inventory Update Rule. (IUR) (40 CFR part 710 subpart B、51FR21438).、(1992) No data、World market for L-aspartic acid in 1982: 450 tonnes、in 1984: 250 tonnes、Production volumes for non-confidential chemicals reported under the Inventory Update Rule. [Table#3169]、General Manufacturing Information: Synthetic Dye and Pigment Manufacturing、Not Known or Reasonably Ascertainable、Oil and Gas Drilling、Extraction、and Support activities、All Other Basic Inorganic Chemical Manufacturing、L-Aspartic acid: ACTIVE、Aspartic acid: ACTIVE、COMMONLY OCCURS IN THE L-FORM. ONE OF THE NONESSENTIAL AMINO ACIDS.、ASPARTIC ACID IS A POTENTIAL FLAVOR PRECURSOR ISOLATED FROM MEAT EXTRACTS、FROM TABLE、...ASPARTATE...FOUND IN VERY HIGH CONCN IN BRAIN...、HAS、POWERFUL EXCITATORY EFFECTS ON NEURONS IN VIRTUALLY EVERY REGION OF THE CNS. ...EFFORTS TO SUPPORT...ASPARTATE AS EXCITATORY、TRANSMITTER、...IN MAMMALIAN CNS HAVE BEEN HAMPERED BY UNAVAILABILITY OF A CONVINCINGLY SELECTIVE RECEPTOR ANTAGONIST.、ASPARTATE、POSTSYNAPTIC PHARMACOLOGY OF ASPARTATE: INCR NA+ & CATION CONDUCTANCES、DEPOLARIZES.、For more General Manufacturing Information (Complete) data for (L)-ASPARTIC ACID (9 total) |
| 类别 | 其他食品添加剂 |
登记用途：Uses: CIR ingredient: Aspartic Acid、A non-essential amino acid、[Merck Index] [REPROTOX] Used in biological and clinical studies、to make culture media、and in aspartame products (detergents、fungicides、germicides、and metal complexations)、[HSDB] Used in chemical synthesis、cosmetics、and pharmaceuticals、[IUCLID] Used as a flavoring agent and nutritional supplement、[FDA]、BIOLOGICAL & CLINICAL STUDIES、PREPN OF CULTURE MEDIA、ORG INTERMEDIATE、INGREDIENT OF ASPARTAME、DETERGENTS、FUNGICIDES、GERMICIDES、METAL COMPLEXATION、ASPARTIC ACID、Used in flavor reaction products and pharmaceuticals formulations and intermediates、Roborant、Used as a raw material in the synthesis of peptide drugs、For more Uses (Complete) data for (L)-ASPARTIC ACID (7 total)、please visit the HSDB record page.、Use (kg、approx.) in Germany (2009): >1000、Consumption (g per capita、approx.) in Germany (2009): 0.0122、Calculated removal (%): 92.1、Use Classification: Flavoring Agents -> JECFA Flavorings Index、Flavouring Agent -> FLAVOURING_AGENT -> JECFA Functional Classes、Cosmetics -> Antistatic、Industry Uses: Not Known or Reasonably Ascertainable、Intermediate、Chelating agent、Household Products: Information on 14 consumer products that contain Aspartic acid、disodium salt in the following categories is provided:、• Auto Products、• Commercial、Institutional、Information on 11 consumer products that contain Aspartic acid in the following categories is provided:、• Inside the Home、• Personal Care、Methods of Manufacturing: Hydrolysis of asparagine、reaction of ammonia with diethyl fumarate、L-Aspartic acid is industrially manufactured by an enzymatic process in which aspartase (l-aspartate ammonia lyase、EC 4.3.1.1) catalyzes the addition of ammonia to fumaric acid. Advantages of the enzymatic production method are higher product concentration and productivity and the formation of fewer byproducts. Thus、l-aspartic acid can be easily separated from the reaction mixture by crystallization.、In 1973、an immobilized cell system based on Escherichia coli cells entrapped in polyacrylamide gel lattice was introduced for large-scale production.、Formulations、Preparations: (VET) COMMERCIALLY AVAILABLE AS MIXT OF POTASSIUM & MAGNESIUM ASPARTATES= SPARTASE.、AVAILABLE COMMERCIALLY AS D(-)-、L(+)-、& DL-ASPARTIC ACID.、150 G ASPARTIC ACID WAS POLYMERIZED IN PRESENCE OF H3PO4 TO GIVE 150 G POLY(DEHYDROASPARTIC ACID) WHICH WAS TREATED WITH MORPHOLINE. POLYMER WAS INCORPORATED INTO AN ANIONIC SHAMPOO WITH 4% CONCN.、USP and FCC grades、99% min grade、U.S. Production: 2023: 50、000 - <75、000 lb、2022: 250、000 - <550、2021: 400、2020: 250、000 - <400、This chemical is listed as a High Production Volume (HPV) (65FR81686). Chemicals listed as HPV were produced in or imported into the U.S. in >1 million pounds in 1990 and、or 1994. The HPV list is based on the 1990 Inventory Update Rule. (IUR) (40 CFR part 710 subpart B、51FR21438).、(1992) No data、World market for L-aspartic acid in 1982: 450 tonnes、in 1984: 250 tonnes、Production volumes for non-confidential chemicals reported under the Inventory Update Rule. [Table#3169]、General Manufacturing Information: Synthetic Dye and Pigment Manufacturing、Not Known or Reasonably Ascertainable、Oil and Gas Drilling、Extraction、and Support activities、All Other Basic Inorganic Chemical Manufacturing、L-Aspartic acid: ACTIVE、Aspartic acid: ACTIVE、COMMONLY OCCURS IN THE L-FORM. ONE OF THE NONESSENTIAL AMINO ACIDS.、ASPARTIC ACID IS A POTENTIAL FLAVOR PRECURSOR ISOLATED FROM MEAT EXTRACTS、FROM TABLE、...ASPARTATE...FOUND IN VERY HIGH CONCN IN BRAIN...、HAS、POWERFUL EXCITATORY EFFECTS ON NEURONS IN VIRTUALLY EVERY REGION OF THE CNS. ...EFFORTS TO SUPPORT...ASPARTATE AS EXCITATORY、TRANSMITTER、...IN MAMMALIAN CNS HAVE BEEN HAMPERED BY UNAVAILABILITY OF A CONVINCINGLY SELECTIVE RECEPTOR ANTAGONIST.、ASPARTATE、POSTSYNAPTIC PHARMACOLOGY OF ASPARTATE: INCR NA+ & CATION CONDUCTANCES、DEPOLARIZES.、For more General Manufacturing Information (Complete) data for (L)-ASPARTIC ACID (9 total)。
L-天冬氨酸，L-天冬酸 是一种食品级化合物，登记 CAS 号为 56-84-8，分子式 C4H7NO4（分子量 133.10），归属于食品添加剂大类化工原料。
登记 CAS 号：56-84-8
其分子式 C4H7NO4 由 4 个碳、7 个氢、1 个氮、4 个氧 组成。
别名/同义词：L-天冬氨酸，L-天冬酸 · Aspartic Acid
所属分类：食品添加剂
L-天冬氨酸，L-天冬酸 的 CAS 登记号为 56-84-8。
分子式 C4H7NO4，分子量 133.10。
别名/同义词：L-天冬氨酸，L-天冬酸、Aspartic Acid。
登记用途：Uses: CIR ingredient: Aspartic Acid、A non-essential amino acid、[Merck Index] [REPROTOX] Used in biological and clinical studies、to make culture media、and in aspartame products (detergents、fungicides、germicides、and metal complexations)、[HSDB] Used in chemical synthesis、cosmetics、and pharmaceuticals、[IUCLID] Used as a flavoring agent and nutritional supplement、[FDA]、BIOLOGICAL & CLINICAL STUDIES、PREPN OF CULTURE MEDIA、ORG INTERMEDIATE、INGREDIENT OF ASPARTAME、DETERGENTS、FUNGICIDES、GERMICIDES、METAL COMPLEXATION、ASPARTIC ACID、Used in flavor reaction products and pharmaceuticals formulations and intermediates、Roborant、Used as a raw material in the synthesis of peptide drugs、For more Uses (Complete) data for (L)-ASPARTIC ACID (7 total)、please visit the HSDB record page.、Use (kg、approx.) in Germany (2009): >1000、Consumption (g per capita、approx.) in Germany (2009): 0.0122、Calculated removal (%): 92.1、Use Classification: Flavoring Agents -> JECFA Flavorings Index、Flavouring Agent -> FLAVOURING_AGENT -> JECFA Functional Classes、Cosmetics -> Antistatic、Industry Uses: Not Known or Reasonably Ascertainable、Intermediate、Chelating agent、Household Products: Information on 14 consumer products that contain Aspartic acid、disodium salt in the following categories is provided:、• Auto Products、• Commercial、Institutional、Information on 11 consumer products that contain Aspartic acid in the following categories is provided:、• Inside the Home、• Personal Care、Methods of Manufacturing: Hydrolysis of asparagine、reaction of ammonia with diethyl fumarate、L-Aspartic acid is industrially manufactured by an enzymatic process in which aspartase (l-aspartate ammonia lyase、EC 4.3.1.1) catalyzes the addition of ammonia to fumaric acid. Advantages of the enzymatic production method are higher product concentration and productivity and the formation of fewer byproducts. Thus、l-aspartic acid can be easily separated from the reaction mixture by crystallization.、In 1973、an immobilized cell system based on Escherichia coli cells entrapped in polyacrylamide gel lattice was introduced for large-scale production.、Formulations、Preparations: (VET) COMMERCIALLY AVAILABLE AS MIXT OF POTASSIUM & MAGNESIUM ASPARTATES= SPARTASE.、AVAILABLE COMMERCIALLY AS D(-)-、L(+)-、& DL-ASPARTIC ACID.、150 G ASPARTIC ACID WAS POLYMERIZED IN PRESENCE OF H3PO4 TO GIVE 150 G POLY(DEHYDROASPARTIC ACID) WHICH WAS TREATED WITH MORPHOLINE. POLYMER WAS INCORPORATED INTO AN ANIONIC SHAMPOO WITH 4% CONCN.、USP and FCC grades、99% min grade、U.S. Production: 2023: 50、000 - <75、000 lb、2022: 250、000 - <550、2021: 400、2020: 250、000 - <400、This chemical is listed as a High Production Volume (HPV) (65FR81686). Chemicals listed as HPV were produced in or imported into the U.S. in >1 million pounds in 1990 and、or 1994. The HPV list is based on the 1990 Inventory Update Rule. (IUR) (40 CFR part 710 subpart B、51FR21438).、(1992) No data、World market for L-aspartic acid in 1982: 450 tonnes、in 1984: 250 tonnes、Production volumes for non-confidential chemicals reported under the Inventory Update Rule. [Table#3169]、General Manufacturing Information: Synthetic Dye and Pigment Manufacturing、Not Known or Reasonably Ascertainable、Oil and Gas Drilling、Extraction、and Support activities、All Other Basic Inorganic Chemical Manufacturing、L-Aspartic acid: ACTIVE、Aspartic acid: ACTIVE、COMMONLY OCCURS IN THE L-FORM. ONE OF THE NONESSENTIAL AMINO ACIDS.、ASPARTIC ACID IS A POTENTIAL FLAVOR PRECURSOR ISOLATED FROM MEAT EXTRACTS、FROM TABLE、...ASPARTATE...FOUND IN VERY HIGH CONCN IN BRAIN...、HAS、POWERFUL EXCITATORY EFFECTS ON NEURONS IN VIRTUALLY EVERY REGION OF THE CNS. ...EFFORTS TO SUPPORT...ASPARTATE AS EXCITATORY、TRANSMITTER、...IN MAMMALIAN CNS HAVE BEEN HAMPERED BY UNAVAILABILITY OF A CONVINCINGLY SELECTIVE RECEPTOR ANTAGONIST.、ASPARTATE、POSTSYNAPTIC PHARMACOLOGY OF ASPARTATE: INCR NA+ & CATION CONDUCTANCES、DEPOLARIZES.、For more General Manufacturing Information (Complete) data for (L)-ASPARTIC ACID (9 total)。
所属分类：其他食品添加剂。
L-天冬氨酸，L-天冬酸（CAS 56-84-8）的独立参考数据，整理自公开化学数据库。
| CAS Registry Number | 56-84-8 |
|---|---|
| PubChem CID | 5960 |
| Molecular formula | C4H7NO4 |
| Molecular weight | 133.04 g/mol |
| IUPAC name | (2S)-2-aminobutanedioic acid |
| InChIKey | CKLJMWTZIZZHCS-REOHCLBHSA-N |
| UNII (FDA) | 30KYC7MIAI |
| ChEBI ID | CHEBI:17053 |
| FEMA number | 3656 |
| JECFA number | 1429 |
| Molecular Weight | 133.10 |
|---|---|
| XLogP3 | -2.8 |
| Hydrogen Bond Donor Count | 3 |
| Hydrogen Bond Acceptor Count | 5 |
| Rotatable Bond Count | 3 |
| Exact Mass | 133.03750770 |
| Monoisotopic Mass | 133.03750770 |
| Topological Polar Surface Area | 101 |
| Heavy Atom Count | 9 |
| Melting Point | 270 |
|---|---|
| Melting Point | 270-271 °C |
| Melting Point | 270 °C |
| Solubility | 5390 |
| Solubility | In water, 5,360 mg/L at 25 °C |
| Solubility | 5.39 mg/mL |
| Density | 1.6603 at 13 °C |
| Density | 1.7 g/cm³ |
| Vapor Pressure | 0.0000013 [mmHg] |
| LogP | -3.89 |
L-aspartic acid; aspartic acid; 56-84-8; (2S)-2-aminobutanedioic acid; Asparagic acid; L-Aminosuccinic acid; (S)-2-Aminosuccinic acid; Asparaginic acid; L-Asparaginic acid; L-Asparagic acid; (S)-Aspartic acid; Aspartic acid, L-; (S)-Aminobutanedioic acid; L-Asparaginsaeure; Acidum asparticum; L-(+)-Aspartic acid
| Regulatory & Food Contact | EU Flavoring substances FDA Substance added to food: FLAVOR ENHANCER, FLAVORING AGENT OR ADJUVANT, NUTRIENT SUPPLEMENT Flavoring Agents FLAVOURING_AGENT: Flavouring Agent No safety concern at current levels of intake when used as a flavouring agent TRS 928-JECFA 63/98 |
|---|---|
| GHS notification summary | 94.4% (340 / 360) |
| GHS notification summary | 94.4% (340 / 360) |
|---|
This chemical does not meet GHS hazard criteria for 94.4% (340 of 360) of all reports.
Reported as not meeting GHS hazard criteria by 340 of 360 companies (only 5.6% companies provided GHS information). For more detailed information, please visit ECHA C&L website.
Aspartic Acid is identified by CAS 56-84-8, molecular formula C4H7NO4 and molecular weight 133.04 g/mol. UNII 30KYC7MIAI; ChEBI 17053; InChIKey CKLJMWTZIZZHCS-REOHCLBHSA-N. Melting Point: 270; Melting Point: 270-271 °C; Melting Point: 270 °C.
数据来源：PubChem / Wikidata；与随货 COA 不一致时以 COA 为准。
English page: Aspartic Acid