4-Phenylbutyric acid

Independent reference data for 4-Phenylbutyric acid (CAS 1821-12-1), compiled from public chemistry databases.

Registry identifiers across databases

Computed descriptors

Physicochemical values on record

Documented uses on record

Phenylbutyric acid is used for the treatment of various conditions, including urea cycle disorders, neonatal-onset deficiency, late-onset deficiency disease in patients with a history of hyperammonemic encephalopathy. Phenylbutyric acid must be combined with dietary protein restriction and, in some cases, essential amino acid supplementation. Phenylbutyric acid, as sodium phenylbutyrate, is used in combination with [tauroursodeoxycholic acid] to treat amyotrophic lateral sclerosis (ALS) in adults.Phenylbutyrate and sodium benzoate are orphan drugs approved for the treatment of hyperammonemia in patients with urea cycle disorders, a series of at least 8 rare genetic enzyme deficiencies. The urea cycle is the major pathway of elimination of excess nitrogen including ammonia, and absence of one of the urea cycle enzymes often causes elevations in serum ammonia which can be severe, life-threatening and result in permanent neurologic damage and cognitive deficiencies. Both phenylbutyrate and sodium benzoate act

Synonyms and trade names

4-PHENYLBUTYRIC ACID; 4-Phenylbutanoic acid; 1821-12-1; Benzenebutanoic acid; Benzenebutyric acid; Phenylbutyric acid; gamma-Phenylbutyric acid; omega-Phenylbutanoic acid; 4-Phenyl-n-butyric acid; CHEBI:41500; omega-phenylbutyric acid; NSC-295; gamma-Phenyl-n-butyric acid; 7WY7YBI87E; NSC295; DTXSID2037631

GHS hazard classification

Reported hazard statements	H315 (83.3%), H319 (100%), H335 (75%)

H315 (83.3%): Causes skin irritation [Warning Skin corrosion/irritation]

H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]

What the public record says

4-Phenylbutyric acid · CAS 1821-12-1 · C10H12O2. UNII 7WY7YBI87E. Boiling Point: 290.00 °C. @ 760.00 mm Hg; Melting Point: 47 - 49 °C; Solubility: 18 mg/mL.

Physical description and handling notes

Source: PubChem / Wikidata; the batch COA governs where values differ.