4-苯基丁酸

4-苯基丁酸（CAS 1821-12-1）的独立参考数据，整理自公开化学数据库。

各数据库的登记标识

计算分子描述符

在册的理化数值

在册的记载用途

Phenylbutyric acid is used for the treatment of various conditions, including urea cycle disorders, neonatal-onset deficiency, late-onset deficiency disease in patients with a history of hyperammonemic encephalopathy. Phenylbutyric acid must be combined with dietary protein restriction and, in some cases, essential amino acid supplementation. Phenylbutyric acid, as sodium phenylbutyrate, is used in combination with [tauroursodeoxycholic acid] to treat amyotrophic lateral sclerosis (ALS) in adults.Phenylbutyrate and sodium benzoate are orphan drugs approved for the treatment of hyperammonemia in patients with urea cycle disorders, a series of at least 8 rare genetic enzyme deficiencies. The urea cycle is the major pathway of elimination of excess nitrogen including ammonia, and absence of one of the urea cycle enzymes often causes elevations in serum ammonia which can be severe, life-threatening and result in permanent neurologic damage and cognitive deficiencies. Both phenylbutyrate and sodium benzoate act

同义词与商品名

4-PHENYLBUTYRIC ACID; 4-Phenylbutanoic acid; 1821-12-1; Benzenebutanoic acid; Benzenebutyric acid; Phenylbutyric acid; gamma-Phenylbutyric acid; omega-Phenylbutanoic acid; 4-Phenyl-n-butyric acid; CHEBI:41500; omega-phenylbutyric acid; NSC-295; gamma-Phenyl-n-butyric acid; 7WY7YBI87E; NSC295; DTXSID2037631

GHS 危害分类

Reported hazard statements	H315 (83.3%), H319 (100%), H335 (75%)

H315 (83.3%): Causes skin irritation [Warning Skin corrosion/irritation]

H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]

公开数据库对它的描述

4-Phenylbutyric acid · CAS 1821-12-1 · C10H12O2. UNII 7WY7YBI87E. Boiling Point: 290.00 °C. @ 760.00 mm Hg; Melting Point: 47 - 49 °C; Solubility: 18 mg/mL.

物理形态与操作说明

数据来源：PubChem / Wikidata；与随货 COA 不一致时以 COA 为准。