头孢氨苄一水合物（CAS 15686-71-2）：分子式 C16H17N3O4S、分子量 347.4。
| CAS号 | 15686-71-2 |
|---|---|
| 分子式 | C16H17N3O4S |
| 分子量 | 347.4 |
| 熔点 | 326.8 |
| 沸点 | 727.4 |
| LogP | 0.65 |
| 应用领域 | Uses: ANTIBIOTIC FOR INFECTIONS OF THE RESPIRATORY & GENITOURINARY TRACTS & OF THE SKIN、EYE、& BONE、ANTIBIOTIC FOR VETERINARY USE、MEDICATION、MEDICATION (VET):、Use (kg、approx.) in Germany (2009): >1000、exact) in Germany (2009): 2020、Use (kg) in USA (2002): 148000、Consumption (g per capita、approx.) in Germany (2009): 0.0122、exact) in Germany (2009): 0.0247、Consumption (g per capita) in the USA (2002): 0.525、Excretion rate: 0.8、Calculated removal (%): 22、Use Classification: Animal Drugs -> FDA Approved Animal Drug Products (Green Book) -> Active Ingredients、Pharmaceuticals -> Animal Drugs -> Approved in Taiwan、Methods of Manufacturing: ACYLATION OF 7-AMINO-3-METHYL-8-OXO-5-THIA-1-AZABICYCLO[4.2.0]OCT-2-ENE-2-CARBOXYLIC ACID (PREPARED FROM CEPHALOSPORIN C) WITH 2-PHENYLGLYCINE IN AN APPROPRIATE DEHYDRATING ENVIRONMENT、7-AMINO-3-METHYL-8-OXO-5-THIA-1-AZABICYCLO[4.2.0]OCT-2-ENE-2-CARBOXYLIC ACID、WHICH MAY BE PREPD FROM NATURAL ANTIBIOTIC CEPHALOSPORIN C、IS ACYLATED WITH 2-PHENYLGLYCINE IN APPROPRIATE DEHYDRATING ENVIRONMENT.、Formulations、Preparations: CEPHALEXIN、USP (KEFLEX)、IS MARKETED AS MONOHYDRATE IN SEVERAL FORMS、INCL CAPSULES OF 250 & 500 MG、ORAL SUSPENSIONS PROVIDING、AFTER RECONSTITUTION、125 MG、5 ML OR 250 MG、5 ML、& PEDIATRIC DROPS、100 MG、ML.、Consumption Patterns: ESSENTIALLY 100% AS AN ANTIBIOTIC、U.S. Production: (1977) PROBABLY GREATER THAN 4.54X10+5 GRAMS、(1979) PROBABLY GREATER THAN 4.54X10+5 GRAMS、U.S. Imports: (1979) 2.04X10+7 GRAMS (PRINCPL CUSTMS DISTS)、General Manufacturing Information: RYAN、ET AL、J MED CHEM 12、310 (1969)、MORIN、JACKSON、US PATENT 3、275、626 (1966 TO LILLY)、...、CEPHALEXIN、SEMISYNTHETIC DERIVATIVE OF CEPHALOSPORIN C. |
登记用途：Uses: ANTIBIOTIC FOR INFECTIONS OF THE RESPIRATORY & GENITOURINARY TRACTS & OF THE SKIN、EYE、& BONE、ANTIBIOTIC FOR VETERINARY USE、MEDICATION、MEDICATION (VET):、Use (kg、approx.) in Germany (2009): >1000、exact) in Germany (2009): 2020、Use (kg) in USA (2002): 148000、Consumption (g per capita、approx.) in Germany (2009): 0.0122、exact) in Germany (2009): 0.0247、Consumption (g per capita) in the USA (2002): 0.525、Excretion rate: 0.8、Calculated removal (%): 22、Use Classification: Animal Drugs -> FDA Approved Animal Drug Products (Green Book) -> Active Ingredients、Pharmaceuticals -> Animal Drugs -> Approved in Taiwan、Methods of Manufacturing: ACYLATION OF 7-AMINO-3-METHYL-8-OXO-5-THIA-1-AZABICYCLO[4.2.0]OCT-2-ENE-2-CARBOXYLIC ACID (PREPARED FROM CEPHALOSPORIN C) WITH 2-PHENYLGLYCINE IN AN APPROPRIATE DEHYDRATING ENVIRONMENT、7-AMINO-3-METHYL-8-OXO-5-THIA-1-AZABICYCLO[4.2.0]OCT-2-ENE-2-CARBOXYLIC ACID、WHICH MAY BE PREPD FROM NATURAL ANTIBIOTIC CEPHALOSPORIN C、IS ACYLATED WITH 2-PHENYLGLYCINE IN APPROPRIATE DEHYDRATING ENVIRONMENT.、Formulations、Preparations: CEPHALEXIN、USP (KEFLEX)、IS MARKETED AS MONOHYDRATE IN SEVERAL FORMS、INCL CAPSULES OF 250 & 500 MG、ORAL SUSPENSIONS PROVIDING、AFTER RECONSTITUTION、125 MG、5 ML OR 250 MG、5 ML、& PEDIATRIC DROPS、100 MG、ML.、Consumption Patterns: ESSENTIALLY 100% AS AN ANTIBIOTIC、U.S. Production: (1977) PROBABLY GREATER THAN 4.54X10+5 GRAMS、(1979) PROBABLY GREATER THAN 4.54X10+5 GRAMS、U.S. Imports: (1979) 2.04X10+7 GRAMS (PRINCPL CUSTMS DISTS)、General Manufacturing Information: RYAN、ET AL、J MED CHEM 12、310 (1969)、MORIN、JACKSON、US PATENT 3、275、626 (1966 TO LILLY)、...、CEPHALEXIN、SEMISYNTHETIC DERIVATIVE OF CEPHALOSPORIN C.。
头孢氨苄一水合物 是一种化工化合物，登记 CAS 号为 15686-71-2，分子式 C16H17N3O4S（分子量 347.4）。
登记 CAS 号：15686-71-2
其分子式 C16H17N3O4S 由 16 个碳、17 个氢、3 个氮、4 个氧、1 个硫 组成。
别名/同义词：头孢氨苄一水合物 · CEPHALEXIN · Cephalexin Monohydrate
头孢氨苄一水合物 的 CAS 登记号为 15686-71-2。
分子式 C16H17N3O4S，分子量 347.4。
别名/同义词：头孢氨苄一水合物、CEPHALEXIN、Cephalexin Monohydrate。
登记用途：Uses: ANTIBIOTIC FOR INFECTIONS OF THE RESPIRATORY & GENITOURINARY TRACTS & OF THE SKIN、EYE、& BONE、ANTIBIOTIC FOR VETERINARY USE、MEDICATION、MEDICATION (VET):、Use (kg、approx.) in Germany (2009): >1000、exact) in Germany (2009): 2020、Use (kg) in USA (2002): 148000、Consumption (g per capita、approx.) in Germany (2009): 0.0122、exact) in Germany (2009): 0.0247、Consumption (g per capita) in the USA (2002): 0.525、Excretion rate: 0.8、Calculated removal (%): 22、Use Classification: Animal Drugs -> FDA Approved Animal Drug Products (Green Book) -> Active Ingredients、Pharmaceuticals -> Animal Drugs -> Approved in Taiwan、Methods of Manufacturing: ACYLATION OF 7-AMINO-3-METHYL-8-OXO-5-THIA-1-AZABICYCLO[4.2.0]OCT-2-ENE-2-CARBOXYLIC ACID (PREPARED FROM CEPHALOSPORIN C) WITH 2-PHENYLGLYCINE IN AN APPROPRIATE DEHYDRATING ENVIRONMENT、7-AMINO-3-METHYL-8-OXO-5-THIA-1-AZABICYCLO[4.2.0]OCT-2-ENE-2-CARBOXYLIC ACID、WHICH MAY BE PREPD FROM NATURAL ANTIBIOTIC CEPHALOSPORIN C、IS ACYLATED WITH 2-PHENYLGLYCINE IN APPROPRIATE DEHYDRATING ENVIRONMENT.、Formulations、Preparations: CEPHALEXIN、USP (KEFLEX)、IS MARKETED AS MONOHYDRATE IN SEVERAL FORMS、INCL CAPSULES OF 250 & 500 MG、ORAL SUSPENSIONS PROVIDING、AFTER RECONSTITUTION、125 MG、5 ML OR 250 MG、5 ML、& PEDIATRIC DROPS、100 MG、ML.、Consumption Patterns: ESSENTIALLY 100% AS AN ANTIBIOTIC、U.S. Production: (1977) PROBABLY GREATER THAN 4.54X10+5 GRAMS、(1979) PROBABLY GREATER THAN 4.54X10+5 GRAMS、U.S. Imports: (1979) 2.04X10+7 GRAMS (PRINCPL CUSTMS DISTS)、General Manufacturing Information: RYAN、ET AL、J MED CHEM 12、310 (1969)、MORIN、JACKSON、US PATENT 3、275、626 (1966 TO LILLY)、...、CEPHALEXIN、SEMISYNTHETIC DERIVATIVE OF CEPHALOSPORIN C.。
头孢氨苄一水合物（CAS 15686-71-2）的独立参考数据，整理自公开化学数据库。
| CAS Registry Number | 15686-71-2 |
|---|---|
| PubChem CID | 27447 |
| Molecular formula | C16H17N3O4S |
| IUPAC name | (6R,7R)-7-[[(2R)-2-amino-2-phenylacetyl]amino]-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid |
| UNII (FDA) | 5SFF1W6677 |
| Molecular Weight | 347.4 |
|---|---|
| XLogP3 | 0.6 |
| Hydrogen Bond Donor Count | 3 |
| Hydrogen Bond Acceptor Count | 6 |
| Rotatable Bond Count | 4 |
| Exact Mass | 347.09397721 |
| Monoisotopic Mass | 347.09397721 |
| Topological Polar Surface Area | 138 |
| Heavy Atom Count | 24 |
| Boiling Point | 727.4 |
|---|---|
| Melting Point | 326.8 |
| Melting Point | 326.8 °C |
| Solubility | 10mg/mL |
| Solubility | 2.97e-01 g/L |
| LogP | 0.65 |
| LogP | logP = 0.65 |
| Dissociation Constants | 2.53 |
| Dissociation Constants | 7.14 |
| Dissociation Constants | PKA: 5.2, 7.3 |
cephalexin; Cefalexin; 15686-71-2; Cephacillin; Ceporexin; Mamalexin; Ceporex; Keflex; Carnosporin; Cefaleksin; Cephalexine; Cephalexinum; Ceporexine; Sinthecillin; Uphalexin; Alsporin
| Reported hazard statements | H317 (100%), H334 (100%) |
|---|
H317 (100%): May cause an allergic skin reaction [Warning Sensitization, Skin]
H334 (100%): May cause allergy or asthma symptoms or breathing difficulties if inhaled [Danger Sensitization, respiratory]
Cephalexin Monohydrate · CAS 15686-71-2 · C16H17N3O4S. UNII 5SFF1W6677. Boiling Point: 727.4; Melting Point: 326.8; Melting Point: 326.8 °C.
数据来源：PubChem / Wikidata；与随货 COA 不一致时以 COA 为准。
English page: CEPHALEXIN