CEPHALEXIN

CAS 15686-71-2C16H17N3O4SMW 347.4

CEPHALEXIN (CAS 15686-71-2) — formula C16H17N3O4S, molecular weight 347.4.

Product Overview

CAS Number	15686-71-2
Molecular Formula	C16H17N3O4S
Molecular Weight	347.4
Melting Point	326.8
Boiling Point	727.4
LogP	0.65
Applications	Uses: ANTIBIOTIC FOR INFECTIONS OF THE RESPIRATORY & GENITOURINARY TRACTS & OF THE SKIN, EYE, & BONE, ANTIBIOTIC FOR VETERINARY USE, MEDICATION, MEDICATION (VET):, Use (kg, approx.) in Germany (2009): >1000, exact) in Germany (2009): 2020, Use (kg) in USA (2002): 148000, Consumption (g per capita, approx.) in Germany (2009): 0.0122, exact) in Germany (2009): 0.0247, Consumption (g per capita) in the USA (2002): 0.525, Excretion rate: 0.8, Calculated removal (%): 22, Use Classification: Animal Drugs -> FDA Approved Animal Drug Products (Green Book) -> Active Ingredients, Pharmaceuticals -> Animal Drugs -> Approved in Taiwan, Methods of Manufacturing: ACYLATION OF 7-AMINO-3-METHYL-8-OXO-5-THIA-1-AZABICYCLO[4.2.0]OCT-2-ENE-2-CARBOXYLIC ACID (PREPARED FROM CEPHALOSPORIN C) WITH 2-PHENYLGLYCINE IN AN APPROPRIATE DEHYDRATING ENVIRONMENT, 7-AMINO-3-METHYL-8-OXO-5-THIA-1-AZABICYCLO[4.2.0]OCT-2-ENE-2-CARBOXYLIC ACID, WHICH MAY BE PREPD FROM NATURAL ANTIBIOTIC CEPHALOSPORIN C, IS ACYLATED WITH 2-PHENYLGLYCINE IN APPROPRIATE DEHYDRATING ENVIRONMENT., Formulations, Preparations: CEPHALEXIN, USP (KEFLEX), IS MARKETED AS MONOHYDRATE IN SEVERAL FORMS, INCL CAPSULES OF 250 & 500 MG, ORAL SUSPENSIONS PROVIDING, AFTER RECONSTITUTION, 125 MG, 5 ML OR 250 MG, 5 ML, & PEDIATRIC DROPS, 100 MG, ML., Consumption Patterns: ESSENTIALLY 100% AS AN ANTIBIOTIC, U.S. Production: (1977) PROBABLY GREATER THAN 4.54X10+5 GRAMS, (1979) PROBABLY GREATER THAN 4.54X10+5 GRAMS, U.S. Imports: (1979) 2.04X10+7 GRAMS (PRINCPL CUSTMS DISTS), General Manufacturing Information: RYAN, ET AL, J MED CHEM 12, 310 (1969), MORIN, JACKSON, US PATENT 3, 275, 626 (1966 TO LILLY), ..., CEPHALEXIN, SEMISYNTHETIC DERIVATIVE OF CEPHALOSPORIN C.

Applications

Documented applications: Uses: ANTIBIOTIC FOR INFECTIONS OF THE RESPIRATORY & GENITOURINARY TRACTS & OF THE SKIN, EYE, & BONE, ANTIBIOTIC FOR VETERINARY USE, MEDICATION, MEDICATION (VET):, Use (kg, approx.) in Germany (2009): >1000, exact) in Germany (2009): 2020, Use (kg) in USA (2002): 148000, Consumption (g per capita, approx.) in Germany (2009): 0.0122, exact) in Germany (2009): 0.0247, Consumption (g per capita) in the USA (2002): 0.525, Excretion rate: 0.8, Calculated removal (%): 22, Use Classification: Animal Drugs -> FDA Approved Animal Drug Products (Green Book) -> Active Ingredients, Pharmaceuticals -> Animal Drugs -> Approved in Taiwan, Methods of Manufacturing: ACYLATION OF 7-AMINO-3-METHYL-8-OXO-5-THIA-1-AZABICYCLO[4.2.0]OCT-2-ENE-2-CARBOXYLIC ACID (PREPARED FROM CEPHALOSPORIN C) WITH 2-PHENYLGLYCINE IN AN APPROPRIATE DEHYDRATING ENVIRONMENT, 7-AMINO-3-METHYL-8-OXO-5-THIA-1-AZABICYCLO[4.2.0]OCT-2-ENE-2-CARBOXYLIC ACID, WHICH MAY BE PREPD FROM NATURAL ANTIBIOTIC CEPHALOSPORIN C, IS ACYLATED WITH 2-PHENYLGLYCINE IN APPROPRIATE DEHYDRATING ENVIRONMENT., Formulations, Preparations: CEPHALEXIN, USP (KEFLEX), IS MARKETED AS MONOHYDRATE IN SEVERAL FORMS, INCL CAPSULES OF 250 & 500 MG, ORAL SUSPENSIONS PROVIDING, AFTER RECONSTITUTION, 125 MG, 5 ML OR 250 MG, 5 ML, & PEDIATRIC DROPS, 100 MG, ML., Consumption Patterns: ESSENTIALLY 100% AS AN ANTIBIOTIC, U.S. Production: (1977) PROBABLY GREATER THAN 4.54X10+5 GRAMS, (1979) PROBABLY GREATER THAN 4.54X10+5 GRAMS, U.S. Imports: (1979) 2.04X10+7 GRAMS (PRINCPL CUSTMS DISTS), General Manufacturing Information: RYAN, ET AL, J MED CHEM 12, 310 (1969), MORIN, JACKSON, US PATENT 3, 275, 626 (1966 TO LILLY), ..., CEPHALEXIN, SEMISYNTHETIC DERIVATIVE OF CEPHALOSPORIN C..

Technical Profile

What this product is

CEPHALEXIN is a chemical compound with CAS registry number 15686-71-2 and molecular formula C16H17N3O4S (molecular weight 347.4).

Identification

CAS number: 15686-71-2

Its molecular formula C16H17N3O4S comprises 16 C, 17 H, 3 N, 4 O, 1 S atoms.

Also known as: CEPHALEXIN · 头孢氨苄 · Cephalexin Monohydrate

Frequently Asked Questions

What is the CAS number of CEPHALEXIN?

The CAS registry number of CEPHALEXIN is 15686-71-2.

What is the molecular formula and molecular weight of CEPHALEXIN?

Molecular formula C16H17N3O4S, molecular weight 347.4.

What other names is CEPHALEXIN known by?

It is also registered under: CEPHALEXIN, 头孢氨苄, Cephalexin Monohydrate.

What are the documented applications of CEPHALEXIN?

Recorded applications: Uses: ANTIBIOTIC FOR INFECTIONS OF THE RESPIRATORY & GENITOURINARY TRACTS & OF THE SKIN, EYE, & BONE, ANTIBIOTIC FOR VETERINARY USE, MEDICATION, MEDICATION (VET):, Use (kg, approx.) in Germany (2009): >1000, exact) in Germany (2009): 2020, Use (kg) in USA (2002): 148000, Consumption (g per capita, approx.) in Germany (2009): 0.0122, exact) in Germany (2009): 0.0247, Consumption (g per capita) in the USA (2002): 0.525, Excretion rate: 0.8, Calculated removal (%): 22, Use Classification: Animal Drugs -> FDA Approved Animal Drug Products (Green Book) -> Active Ingredients, Pharmaceuticals -> Animal Drugs -> Approved in Taiwan, Methods of Manufacturing: ACYLATION OF 7-AMINO-3-METHYL-8-OXO-5-THIA-1-AZABICYCLO[4.2.0]OCT-2-ENE-2-CARBOXYLIC ACID (PREPARED FROM CEPHALOSPORIN C) WITH 2-PHENYLGLYCINE IN AN APPROPRIATE DEHYDRATING ENVIRONMENT, 7-AMINO-3-METHYL-8-OXO-5-THIA-1-AZABICYCLO[4.2.0]OCT-2-ENE-2-CARBOXYLIC ACID, WHICH MAY BE PREPD FROM NATURAL ANTIBIOTIC CEPHALOSPORIN C, IS ACYLATED WITH 2-PHENYLGLYCINE IN APPROPRIATE DEHYDRATING ENVIRONMENT., Formulations, Preparations: CEPHALEXIN, USP (KEFLEX), IS MARKETED AS MONOHYDRATE IN SEVERAL FORMS, INCL CAPSULES OF 250 & 500 MG, ORAL SUSPENSIONS PROVIDING, AFTER RECONSTITUTION, 125 MG, 5 ML OR 250 MG, 5 ML, & PEDIATRIC DROPS, 100 MG, ML., Consumption Patterns: ESSENTIALLY 100% AS AN ANTIBIOTIC, U.S. Production: (1977) PROBABLY GREATER THAN 4.54X10+5 GRAMS, (1979) PROBABLY GREATER THAN 4.54X10+5 GRAMS, U.S. Imports: (1979) 2.04X10+7 GRAMS (PRINCPL CUSTMS DISTS), General Manufacturing Information: RYAN, ET AL, J MED CHEM 12, 310 (1969), MORIN, JACKSON, US PATENT 3, 275, 626 (1966 TO LILLY), ..., CEPHALEXIN, SEMISYNTHETIC DERIVATIVE OF CEPHALOSPORIN C..

PubChem Public Data

Independent reference data for CEPHALEXIN (CAS 15686-71-2), compiled from public chemistry databases.

Registry identifiers across databases

CAS Registry Number	15686-71-2
PubChem CID	27447
Molecular formula	C16H17N3O4S
IUPAC name	(6R,7R)-7-[[(2R)-2-amino-2-phenylacetyl]amino]-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
UNII (FDA)	5SFF1W6677

Computed descriptors

Molecular Weight	347.4
XLogP3	0.6
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	4
Exact Mass	347.09397721
Monoisotopic Mass	347.09397721
Topological Polar Surface Area	138
Heavy Atom Count	24

Physicochemical values on record

Boiling Point	727.4
Melting Point	326.8
Melting Point	326.8 °C
Solubility	10mg/mL
Solubility	2.97e-01 g/L
LogP	0.65
LogP	logP = 0.65
Dissociation Constants	2.53
Dissociation Constants	7.14
Dissociation Constants	PKA: 5.2, 7.3

Documented uses on record

Synonyms and trade names

cephalexin; Cefalexin; 15686-71-2; Cephacillin; Ceporexin; Mamalexin; Ceporex; Keflex; Carnosporin; Cefaleksin; Cephalexine; Cephalexinum; Ceporexine; Sinthecillin; Uphalexin; Alsporin

GHS hazard classification

Reported hazard statements	H317 (100%), H334 (100%)

H317 (100%): May cause an allergic skin reaction [Warning Sensitization, Skin]

H334 (100%): May cause allergy or asthma symptoms or breathing difficulties if inhaled [Danger Sensitization, respiratory]

What the public record says

Cephalexin Monohydrate · CAS 15686-71-2 · C16H17N3O4S. UNII 5SFF1W6677. Boiling Point: 727.4; Melting Point: 326.8; Melting Point: 326.8 °C.

Physical description and handling notes

Source: PubChem / Wikidata; the batch COA governs where values differ.