5-甲酰四氢叶酸

Name: 5-甲酰四氢叶酸
Brand: 济南圣和化工有限公司

CAS 58-05-9C20H23N7O7MW 473.4

济南圣和化工主营供应 5-甲酰四氢叶酸（CAS 58-05-9），归类于有机化学品，分子式 C20H23N7O7，分子量 473.4。我们面向国内化工贸易与生产企业提供稳定的现货供应，报价响应快，支持对公转账并可开具增值税发票。

产品概览

CAS号	58-05-9
分子式	C20H23N7O7
分子量	473.4
熔点	>260
LogP	-1.2
纯度	按批次COA提供(不公开发布)
包装	按订单/批次确认(不公开发布)
应用领域	有机化学品
类别	有机化学品

应用领域

有机化学品

该产品的下游应用集中在有机化学品。不同客户工艺差异较大，我们支持按需提供样品与小批量试用。

包装与储存

包装规格按订单/批次确认(不公开发布)

纯度规格按批次COA提供(不公开发布)

储存条件密封、阴凉干燥处保存

运输常规化工运输

样品可协商提供

交期现货/按订单安排

供应说明：5-甲酰四氢叶酸常规包装为按订单/批次确认(不公开发布)，储存时应密封置于阴凉干燥处，避免与氧化剂混放。济南圣和化工有限公司支持国内物流发货，大货交期与运费以订单确认为准。

质量与文件

每批产品随货提供 COA（分析证书）；可按需提供 MSDS/技术数据表及第三方检测报告。纯度与包装以批次 COA 及订单确认为准。

关于供应商

选择济南圣和化工有限公司的理由：产品信息透明（含 CAS、分子式、理化参数）、报价响应快（一个工作日内）、单证齐全（COA/MSS/质检资料按需提供）、支持批量与长期协议供货。如需 5-甲酰四氢叶酸以外的配套原料，也欢迎一并列出需求清单。

常见问题

5-甲酰四氢叶酸的 CAS 号是多少？

5-甲酰四氢叶酸的 CAS 号为 58-05-9。

该产品的纯度和包装规格是什么？

常规纯度规格为按批次COA提供(不公开发布)，包装为按订单/批次确认(不公开发布)，随货提供 COA。

5-甲酰四氢叶酸有什么用途？

主要应用于有机化学品。

如何购买或获取报价？

请发送邮件至 info@591daili.com 或通过 WhatsApp 联系，注明产品名称、CAS 号与需求数量，一个工作日内回复报价。供应商：济南圣和化工有限公司。

PubChem 公开数据

Description

5-formyltetrahydrofolic acid · CAS 58-05-9 · C20H23N7O7. UNII Q573I9DVLP. Melting Point: >260; Melting Point: 245 °C (decomp); Collision Cross Section: 201.7 Å² [M-H]-.

Identification

CAS Registry Number	58-05-9
PubChem CID	135403648
Molecular formula	C20H23N7O7
IUPAC name	(2S)-2-[[4-[(2-amino-5-formyl-4-oxo-3,6,7,8-tetrahydropteridin-6-yl)methylamino]benzoyl]amino]pentanedioic acid
UNII (FDA)	Q573I9DVLP

Computed Descriptors

Molecular Weight	473.4
XLogP3	-1.2
Hydrogen Bond Donor Count	7
Hydrogen Bond Acceptor Count	10
Rotatable Bond Count	9
Exact Mass	473.16589610
Monoisotopic Mass	473.16589610
Topological Polar Surface Area	216
Heavy Atom Count	34
Formal Charge	0

Physical & Chemical Properties

Melting Point	>260
Melting Point	245 °C (decomp)
Collision Cross Section	201.7 Å² [M-H]-
Collision Cross Section	197.5 Å² [M+H]+

Physical description & handling notes

Crystals from water with 3 mol of water of crystallization.
Sparingly soluble in water
2.3X10-21 mm Hg at 25 °C at 25 °C /Estimated/
log Kow = -4.45 /Estimated/
Henry's Law constant = 4.4X10-27 atm-cu m/mole at 25 °C /Estimated/
Leucovorin calcium injection, powder for injection, and tablets should be stored at 15-30 °C and protected from light. /Leucovorin calcium/

Documented Uses

For the treatment of osteosarcoma (after high dose methotrexate therapy). Used to diminish the toxicity and counteract the effects of impaired methotrexate elimination and of inadvertent overdosages of folic acid antagonists, and to treat megaloblastic anemias due to folic acid deficiency. Also used in combination with 5-fluorouracil to prolong survival in the palliative treatment of patients with advanced colorectal cancer. Used in cancer chemotherapy involving the drug methotrexate.
(1) Prepared by catalytic reduction of folic acid, (2) produced microbially.
Manufactoring: Shive, US 2741608 (1956 to Res. Corp.)
A member of the folic acid group of vitamins and a growth factor for the bacterium leuconostoc citroforum. Folinic acid is an important metabolite of folic acid and may be the active form in cellular metabolism.
Intermediate product of the metabolism of folic acid; the active form into which that acid is converted in the body, ascorbic acid being a necessary factor in the conversion process.
Information available in 2005 indicated that Leucovorin (folinic acid) was used in the manufacture of pharmaceutical preparations in the following countries: Belgium (1)

Synonyms

folinic acid; leucovorin; 58-05-9; 5-Formyltetrahydrofolic acid; folinate; Folinic acid-SF; 5-formyltetrahydrofolate; Acide folinique; 5-Formyl-5,6,7,8-tetrahydrofolic acid; N5-Formyltetrahydrofolic acid; N5-Formyl-5,6,7,8-tetrahydrofolic acid; Q573I9DVLP; 5-Formyl-5,6,7,8-tetrahydropteroyl-L-glutamic acid; DTXSID0048216; CHEBI:15640; (5-formyl-5,6,7,8-tetrahydropteroyl)glutamate

Frequently Asked Questions

What are the CAS number and molecular formula of 5-formyltetrahydrofolic acid?

CAS 58-05-9; molecular formula C20H23N7O7; molecular weight — g/mol.

What other names is 5-formyltetrahydrofolic acid known by?

folinic acid, leucovorin, 58-05-9, 5-Formyltetrahydrofolic acid, folinate, Folinic acid-SF.

What are the key physical properties of 5-formyltetrahydrofolic acid?

Melting Point: >260; Melting Point: 245 °C (decomp); Collision Cross Section: 201.7 Å² [M-H]-; Collision Cross Section: 197.5 Å² [M+H]+.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.