替泊替尼

Description

Tepotinib · CAS 1100598-32-0 · C29H28N6O2. UNII 1IJV77EI07. Dissociation Constants: 9.5.

Identification

CAS Registry Number	1100598-32-0
PubChem CID	25171648
Molecular formula	C29H28N6O2
IUPAC name	3-[1-[[3-[5-[(1-methylpiperidin-4-yl)methoxy]pyrimidin-2-yl]phenyl]methyl]-6-oxopyridazin-3-yl]benzonitrile
UNII (FDA)	1IJV77EI07

Computed Descriptors

Molecular Weight	492.6
XLogP3	3.4
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	7
Exact Mass	492.22737416
Monoisotopic Mass	492.22737416
Topological Polar Surface Area	94.7
Heavy Atom Count	37
Formal Charge	0

Physical & Chemical Properties

Dissociation Constants	9.5

Documented Uses

• Tepotinib is indicated for the treatment of adult patients with metastatic non-small cell lung cancer (NSCLC) who have mesenchymal-epithelial transition (_MET_) exon 14 skipping alterations.
• Tepotinib is an orally available, small molecule inhibitor of the mesenchymal-epithelial transition (MET) factor tyrosine kinase receptor that is used to treat selected cases of non-small cell lung cancer (NSCLC). Serum aminotransferase elevations are common during therapy with tepotinib, but it has not been linked to instances of clinically apparent liver injury with jaundice.
• Breast Feeding; Lactation; Antineoplastic Agents; Enzyme Inhibitors; Protein Kinase Inhibitors; Tyrosine Kinase Inhibitors
• Take with food. Co-administration with a meal improves the absorption of tepotinib.
• Substances that inhibit or prevent the proliferation of NEOPLASMS.
• Established Pharmacologic Class [EPC] - Kinase Inhibitor

Synonyms

Tepotinib; 1100598-32-0; EMD-1214063; EMD 1214063; EMD1214063; MSC2156119J; MSC-2156119J; MSC2156119; MSC-2156119; 1IJV77EI07; DTXSID70149132; tepotinibum; RefChem:57995; DTXCID0071623; c-Met Inhibitor MSC2156119J; Tepotinib [INN]

Frequently Asked Questions

What are the CAS number and molecular formula of Tepotinib?

CAS 1100598-32-0; molecular formula C29H28N6O2; molecular weight — g/mol.

What other names is Tepotinib known by?

Tepotinib, 1100598-32-0, EMD-1214063, EMD 1214063, EMD1214063, MSC2156119J.

What are the key physical properties of Tepotinib?

Dissociation Constants: 9.5.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.