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Description

Telavancin · CAS 372151-71-8 · C80H106Cl2N11O27P. UNII XK134822Z0.

Identification

CAS Registry Number	372151-71-8
PubChem CID	3081362
Molecular formula	C80H106Cl2N11O27P
UNII (FDA)	XK134822Z0

Computed Descriptors

Molecular Weight	1755.6
XLogP3	-2.1
Hydrogen Bond Donor Count	23
Hydrogen Bond Acceptor Count	31
Rotatable Bond Count	30
Exact Mass	1753.6374295
Monoisotopic Mass	1753.6374295
Topological Polar Surface Area	598
Heavy Atom Count	121
Formal Charge	0

Physical description & handling notes

• Off-white to slightly colored amorphous powder; highly lipophilic and slightly soluble in water /Telavancin hydrochloride/
• Table: Telavancin Hydrochloride Preparations [Table#8173]

Documented Uses

• Telavancin is a semi-synthetic substance derived from the glycopeptide vancomycin by a two-step synthesis followed by purification and isolation. Telavancin contains a lipophilic side chain bond to the amino sugar of vancomycin and an aminomethyl phosphonite group bond to the di-phenol-ring of vancomycin.
• Preparation: M. R. Leadbetter, M. S. Linsell, World Intellectual Property Organization patent 0198328; eidem, United States of America patent 6635618 (2001, 2003 both to Advanced Medicine). Manufacturing process: M. Leadbetter et al., World Intellectual Property Organization patent 03029270 (2001 to Theravance).
• Synthetic derivative of vancomycin
• Breast Feeding; Lactation; Milk, Human; Anti-Infective Agents; Antibacterial Agents; Glycopeptides; Lipoglycopeptides
• Vibativ is indicated for the treatment of adult patients with complicated skin and skin structure infections (cSSSI) caused by susceptible isolates of the following Gram-positive microorganisms: Staphylococcus aureus (including methicillin-susceptible and -resistant isolates), Streptococcus pyogenes, Streptococcus agalactiae, Streptococcus anginosus group (includes S. anginosus, S. intermedius, and S. constellatus), or Enterococcus faecalis (vancomycin-susceptible isolates only). /Included in US product label/
• Vibativ is indicated for the treatment of adult patients with hospital-acquired and ventilator associated bacterial pneumonia (HABP/VABP), caused by susceptible isolates of 45 Staphylococcus aureus (including methicillin-susceptible and -resistant isolates). Vibativ 46 should be reserved for use when alternative treatments are not suitable. /Included in US product label/

Synonyms

Telavancin; 372151-71-8; telavancina; telavancine; Televancin; telavancinum; XK134822Z0; CHEBI:71229; DTXSID10873383; TD6424; Vancomycin, N3''-(2-(decylamino)ethyl)-29-(((phosphonomethyl)amino)methyl)-; VANCOMYCIN, N(SUP 3'')-(2-(DECYLAMINO)ETHYL)-29-(((PHOSPHONOMETHYL)AMINO)METHYL)-; RefChem:56919; DTXCID80820900; J01XA03; 927-282-6

Frequently Asked Questions

What are the CAS number and molecular formula of Telavancin?

CAS 372151-71-8; molecular formula C80H106Cl2N11O27P; molecular weight — g/mol.

What other names is Telavancin known by?

Telavancin, 372151-71-8, telavancina, telavancine, Televancin, telavancinum.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.