曲古抑菌素A

Description

Trichostatin A · CAS 58880-19-6 · C17H22N2O3. UNII 3X2S926L3Z.

Identification

CAS Registry Number	58880-19-6
PubChem CID	444732
Molecular formula	C17H22N2O3
IUPAC name	(2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxohepta-2,4-dienamide
UNII (FDA)	3X2S926L3Z

Computed Descriptors

Molecular Weight	302.37
XLogP3	2.7
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	6
Exact Mass	302.16304257
Monoisotopic Mass	302.16304257
Topological Polar Surface Area	69.6
Heavy Atom Count	22
Formal Charge	0

GHS Hazard Classification

Reported hazard statements	H302, H312, H332 (15%), H315 (98.9%), H317 (98.4%), H319 (99.5%), H335 (98.4%)

Documented Uses

• Substances that destroy fungi by suppressing their ability to grow or reproduce. They differ from FUNGICIDES, INDUSTRIAL because they defend against fungi present in human or animal tissues.
• Compounds which inhibit the synthesis of proteins. They are usually ANTI-BACTERIAL AGENTS or toxins. Mechanism of the action of inhibition includes the interruption of peptide-chain elongation, the blocking the A site of ribosomes, the misreading of the genetic code or the prevention of the attachment of oligosaccharide side chains to glycoproteins.
• Compounds that inhibit HISTONE DEACETYLASES. This class of drugs may influence gene expression by increasing the level of acetylated HISTONES in specific CHROMATIN domains.

Synonyms

trichostatin A; 58880-19-6; DTXSID6037063; CHEBI:46024; 3X2S926L3Z; 2,4-Heptadienamide, 7-(4-(dimethylamino)phenyl)-N-hydroxy-4,6-dimethyl-7-oxo-; 7-(4-(Dimethylamino)phenyl)-N-hydroxy-4,6-dimethyl-7-oxo-2,4-heptadienamide; VTR297; VTR-297; (2E,4E,6R)-7-(4-(dimethylamino)phenyl)-N-hydroxy-4,6-dimethyl-7-oxo-2,4-heptadienamide; NSC-311042; TSA antibioitc; 7-[4-(DIMETHYLAMINO)PHENYL]-N-HYDROXY-4,6-DIMETHYL-7-OXO-2,4-HEPTADIENAMIDE; NSC311042; RefChem:899268; DTXCID4017063

Frequently Asked Questions

What are the CAS number and molecular formula of Trichostatin A?

CAS 58880-19-6; molecular formula C17H22N2O3; molecular weight — g/mol.

What other names is Trichostatin A known by?

trichostatin A, 58880-19-6, DTXSID6037063, CHEBI:46024, 3X2S926L3Z, 2,4-Heptadienamide, 7-(4-(dimethylamino)phenyl)-N-hydroxy-4,6-dimethyl-7-oxo-.

Is Trichostatin A classified as hazardous?

Hazard statements reported: H302, H312, H332, H315, H317.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.