替诺福韦二吡呋酯

Description

Tenofovir disoproxil · CAS 201341-05-1 · C19H30N5O10P. UNII F4YU4LON7I. Boiling Point: 642.7; Melting Point: 113-115; Solubility: 13.4.

Identification

CAS Registry Number	201341-05-1
PubChem CID	5481350
Molecular formula	C19H30N5O10P
IUPAC name	[[(2R)-1-(6-aminopurin-9-yl)propan-2-yl]oxymethyl-(propan-2-yloxycarbonyloxymethoxy)phosphoryl]oxymethyl propan-2-yl carbonate
UNII (FDA)	F4YU4LON7I

Computed Descriptors

Molecular Weight	519.4
XLogP3	1.6
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	14
Rotatable Bond Count	17
Exact Mass	519.17302917
Monoisotopic Mass	519.17302917
Topological Polar Surface Area	185
Heavy Atom Count	35
Formal Charge	0

Physical & Chemical Properties

Boiling Point	642.7
Melting Point	113-115
Solubility	13.4
LogP	1.25
Dissociation Constants	3.75

Documented Uses

• Use (kg) in Switzerland (2009): >500
• Use (kg; approx.) in Germany (2009): >2500
• Consumption (g per capita) in Switzerland (2009): 0.064
• Consumption (g per capita; approx.) in Germany (2009): 0.031
• Consumption (g per capita) in the USA (2002): 0.01
• Agents used in the prophylaxis or therapy of VIRUS DISEASES. Some of the ways they may act include preventing viral replication by inhibiting viral DNA polymerase; binding to specific cell-surface receptors and inhibiting viral penetration or uncoating; inhibiting viral protein synthesis; or blocking late stages of virus assembly.

Synonyms

Tenofovir disoproxil; 201341-05-1; Bis(POC)PMPA; (r)-bis(poc)pmpa; bis-POC-PMPA; tenofovir bis(isopropyloxycarbonyloxymethyl) ester; F4YU4LON7I; 9-((R)-2-((Bis(((isopropoxycarbonyl)oxy)methoxy)phosphinyl)methoxy)propyl)adenine; GS-4331; DTXSID5052757; CHEBI:63717; STRIBILD COMPONENT TENOFOVIR DISOPROXIL; 9-[(r)-2-[[bis[[(isopropoxycarbonyl)oxy]methoxy]phosphinyl]methoxy]propyl]adenine; RefChem:187852; DTXCID2031249; 606-442-6

Frequently Asked Questions

What are the CAS number and molecular formula of Tenofovir disoproxil?

CAS 201341-05-1; molecular formula C19H30N5O10P; molecular weight — g/mol.

What other names is Tenofovir disoproxil known by?

Tenofovir disoproxil, 201341-05-1, Bis(POC)PMPA, (r)-bis(poc)pmpa, bis-POC-PMPA, tenofovir bis(isopropyloxycarbonyloxymethyl) ester.

What are the key physical properties of Tenofovir disoproxil?

Boiling Point: 642.7; Melting Point: 113-115; Solubility: 13.4; LogP: 1.25.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.