Seneciphylline

Description

Seneciphylline · CAS 480-81-9 · C18H23NO5. UNII 0ZYZ9L5454. Melting Point: 423 °F (NTP, 1992); Melting Point: 217--218 °C; Vapor Pressure: 1.2X10-12 mm Hg @ 25 °C /Estimated/.

Identification

CAS Registry Number	480-81-9
PubChem CID	5281750
Molecular formula	C18H23NO5
IUPAC name	(1R,4Z,7R,17R)-4-ethylidene-7-hydroxy-7-methyl-6-methylidene-2,9-dioxa-14-azatricyclo[9.5.1.014,17]heptadec-11-ene-3,8-dione
UNII (FDA)	0ZYZ9L5454

Computed Descriptors

Molecular Weight	333.4
XLogP3	0.7
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	0
Exact Mass	333.15762283
Monoisotopic Mass	333.15762283
Topological Polar Surface Area	76.1
Heavy Atom Count	24
Formal Charge	0

Physical & Chemical Properties

Melting Point	423 °F (NTP, 1992)
Melting Point	217--218 °C
Vapor Pressure	1.2X10-12 mm Hg @ 25 °C /Estimated/
LogP	log Kow = -1.88 @ 25 °C /Estimated/

Physical description & handling notes

• Seneciphylline is a white powder. (NTP, 1992)
• Colorless prisms
• less than 0.1 mg/mL at 64 °F (NTP, 1992)
• Sol in water /Hydrochloride/
• Sol in chloroform; sparingly sol in ethanol, acetone; slightly sol in water
• Difficult solubility in ether and ligroin.

GHS Hazard Classification

Reported hazard statements	H301 (100%)

Documented Uses

• Crotalaria juncea, from which ... /seneciphylline/ has been isolated, is cultivated in India and East Africa for its fibre. In East Africa the root of C. juncea has been reported to be used as a hemoptysis remedy, and the leaf and seeds may be used as food. In India C. juncea was used against impetigo, psoriasis and as an emmenogogue.
• Seneciphylline is a minor constituent of S. jacobaea, which has been used as a medicinal herb in Europe.
• (1977) NOT PRODUCED COMMERCIALLY IN US
• (1979) NOT PRODUCED COMMERCIALLY IN US
• ... Has been isolated from Crotalaria juncea L. (L) Rafin. (family Leguminosae) and from a large number of species in the tribe Senecioneae (family Compositae) ... .
• In animal studies highest concentrations were found in the liver, lungs, kidneys and spleen. /pyrrolizidine alkaloids/

Synonyms

SENECIPHYLLINE; 480-81-9; Seneciphyllin; Jacodine; 13,19-Didehydro-12-hydroxysenecionan-11,16-dione; ALPHA-LONGILOBINE; NSC 30622; NSC-30622; DTXSID8026016; 0ZYZ9L5454; NCI-C61165; Senecionan-11,16-dione, 13,19-didehydro-12-hydroxy-; trans-15-Ethylidene-12beta-hydroxy-12alpha-methyl-13-methylenesenec-1-enine; RefChem:182378; DTXCID306016; C18H23NO5

Frequently Asked Questions

What are the CAS number and molecular formula of Seneciphylline?

CAS 480-81-9; molecular formula C18H23NO5; molecular weight — g/mol.

What other names is Seneciphylline known by?

SENECIPHYLLINE, 480-81-9, Seneciphyllin, Jacodine, 13,19-Didehydro-12-hydroxysenecionan-11,16-dione, ALPHA-LONGILOBINE.

Is Seneciphylline classified as hazardous?

Hazard statements reported: H301.

What are the key physical properties of Seneciphylline?

Melting Point: 423 °F (NTP, 1992); Melting Point: 217--218 °C; Vapor Pressure: 1.2X10-12 mm Hg @ 25 °C /Estimated/; LogP: log Kow = -1.88 @ 25 °C /Estimated/.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.