司美替尼

Description

Selumetinib · CAS 606143-52-6 · C17H15BrClFN4O3. UNII 6UH91I579U.

Identification

CAS Registry Number	606143-52-6
PubChem CID	10127622
Molecular formula	C17H15BrClFN4O3
IUPAC name	6-(4-bromo-2-chloroanilino)-7-fluoro-N-(2-hydroxyethoxy)-3-methylbenzimidazole-5-carboxamide
UNII (FDA)	6UH91I579U

Computed Descriptors

Molecular Weight	457.7
XLogP3	3.6
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	6
Exact Mass	456.00001
Monoisotopic Mass	456.00001
Topological Polar Surface Area	88.4
Heavy Atom Count	27
Formal Charge	0

GHS Hazard Classification

Reported hazard statements	H302 (40%), H317 (80%), H318 (60%), H361 (80%), H373 (80%), H411 (60%), H413 (20%)

Documented Uses

• Selumetinib is indicated for the treatment of neurofibromatosis type 1 (NF1) in adult and pediatric patients one year of age and older who have symptomatic, inoperable plexiform neurofibromas (PN).
• Selumetinib is an oral, small molecule inhibitor of the mitogen activated protein kinase 1 and 2 (MEK1/2) that is used to treat symptomatic, refractory fibromas in neurofibromatosis type 1. Selumetinib is associated with transient and usually mild elevations in serum aminotransferase levels during therapy, but has not been linked to cases of clinically apparent acute liver injury.
• Breast Feeding; Lactation; Milk, Human; Antineoplastic Agents; Enzyme Inhibitors; Protein Kinase Inhibitors; Tyrosine Kinase Inhibitors; Signal Transduction Inhibitors; MEK Inhibitors
• Genetic Disorder Agents, Antineoplastic Agents
• Take on an empty stomach. Avoid consuming food 2 hours before and 1 hour after each dose.
• Established Pharmacologic Class [EPC] - Kinase Inhibitor

Synonyms

Selumetinib; 606143-52-6; AZD6244; ARRY-142886; 5-[(4-BROMO-2-CHLOROPHENYL)AMINO]-4-FLUORO-N-(2-HYDROXYETHOXY)-1-METHYL-1H-BENZIMIDAZOLE-6-CARBOXAMIDE; AZD 6244; AZD-6244; ARRY-886; selumetinibum; DTXSID3048944; 6UH91I579U; ARRY142886; DTXCID0028870; CHEBI:90227; 1H-Benzimidazole-6-carboxamide, 5-((4-bromo-2-chlorophenyl)amino)-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-; 1H-Benzimidazole-6-carboxamide, 5-[(4-bromo-2-chlorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-

Frequently Asked Questions

What are the CAS number and molecular formula of Selumetinib?

CAS 606143-52-6; molecular formula C17H15BrClFN4O3; molecular weight — g/mol.

What other names is Selumetinib known by?

Selumetinib, 606143-52-6, AZD6244, ARRY-142886, 5-[(4-BROMO-2-CHLOROPHENYL)AMINO]-4-FLUORO-N-(2-HYDROXYETHOXY)-1-METHYL-1H-BENZIMIDAZOLE-6-CARBOXAMIDE, AZD 6244.

Is Selumetinib classified as hazardous?

Hazard statements reported: H302, H317, H318, H361, H373.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.