N-甲基乙酰胺

Description

N-Methylacetamide · CAS 79-16-3 · C3H7NO. UNII V0T777481M. Boiling Point: 205 °C; Melting Point: 28 °C; Flash Point: 108 °C.

Identification

CAS Registry Number	79-16-3
PubChem CID	6582
Molecular formula	C3H7NO
IUPAC name	N-methylacetamide
UNII (FDA)	V0T777481M

Computed Descriptors

Molecular Weight	73.09
XLogP3	-1.1
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	1
Rotatable Bond Count	0
Exact Mass	73.052763847
Monoisotopic Mass	73.052763847
Topological Polar Surface Area	29.1
Heavy Atom Count	5
Formal Charge	0

Physical & Chemical Properties

Boiling Point	205 °C
Melting Point	28 °C
Flash Point	108 °C
Solubility	In water, 1X10+6 mg/l @ 20 °C
Density	0.9371 @ 25 °C/4 °C
Vapor Pressure	0.44 [mmHg]
Vapor Pressure	0.44 mm Hg at 23 °C.
LogP	log Kow = -1.05
LogP	-1.05
Heat of Vaporization	59.4 kJ/mol

Physical description & handling notes

• Solid; mp = 28 deg C; [HSDB] White crystalline solid; mp = 26-28 deg C; [Alfa Aesar MSDS]
• NEEDLES
• SOL IN CHLOROFORM
• Soluble in alcohol, ether, acetone, benzene
• When heated to decomposition it emits toxic fumes of /nitrogen oxides/.
• 3.65 centipose (30 °C); 3.23 centipose (35 °C); 3.012 centipose (40 °C)

GHS Hazard Classification

Reported hazard statements	H360 (97.5%), H361

Documented Uses

• Acetic acid + methylamine (amide formation)
• (1975) PROBABLY GREATER THAN 9.08X10+5 GRAMS
• DIMETHYL SULFOXIDE, N-METHYL ACETAMIDE & PYRIDINE N-OXIDE WERE MOST EFFECTIVE AGENTS TESTED FOR INDUCING DIFFERENTIATION OF MURINE ERYTHROLEUKEMIA CELLS IN VITRO.
• MONOMETHYLACETAMIDE IS A METABOLITE OF DIMETHYLACETAMIDE & APPEARS IN MEASURABLE AMOUNTS IN URINE AFTER SINGLE EXPOSURE TO A TLV (THRESHOLD LIMIT VALUE) DOSE OF DIMETHYLACETAMIDE.
• In a recent comparative toxicity & metab study of 4 formamides & on N-methylacetamide, the sole metabolite of N-methylacetamide in the urine of mice was identified as N-(hydroxymethyl)acetamide. There was no evidence of induction of hepatic drug metabolizing enzymes in rats following treatment with N-methylacetamide. N-Methylacetamide influenced neither the sleeping time induced by hexobarbital nor the metabolism of hexobarbital or aniline.

Synonyms

N-METHYLACETAMIDE; 79-16-3; Methylacetamide; Acetamide, N-methyl-; Monomethylacetamide; Methyl acetamide; N-Methyl acetamide; Acetamide, methyl-; N-Monomethylacetamide; DTXSID0047167; Acetic acid, amide, N-methyl; NSC-747; V0T777481M; DTXCID8027167; CHEBI:87321; RefChem:163783

Frequently Asked Questions

What are the CAS number and molecular formula of N-Methylacetamide?

CAS 79-16-3; molecular formula C3H7NO; molecular weight — g/mol.

What other names is N-Methylacetamide known by?

N-METHYLACETAMIDE, 79-16-3, Methylacetamide, Acetamide, N-methyl-, Monomethylacetamide, Methyl acetamide.

Is N-Methylacetamide classified as hazardous?

Hazard statements reported: H360, H361.

What are the key physical properties of N-Methylacetamide?

Boiling Point: 205 °C; Melting Point: 28 °C; Flash Point: 108 °C; Solubility: In water, 1X10+6 mg/l @ 20 °C.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.