来那替尼

Name: 来那替尼
Brand: 济南圣和化工有限公司

CAS 698387-09-6C30H29ClN6O3MW 557.0

济南圣和化工主营供应来那替尼（CAS 698387-09-6），归类于有机化学品，分子式 C30H29ClN6O3，分子量 557.0。我们面向国内化工贸易与生产企业提供稳定的现货供应，报价响应快，支持对公转账并可开具增值税发票。

产品概览

CAS号	698387-09-6
分子式	C30H29ClN6O3
分子量	557.0
LogP	4.9
纯度	按批次COA提供(不公开发布)
包装	按订单/批次确认(不公开发布)
应用领域	有机化学品
类别	有机化学品

应用领域

有机化学品

来那替尼在有机化学品领域使用广泛。采购前请确认纯度等级与包装形式，以批次 COA 为验收依据。

包装与储存

包装规格按订单/批次确认(不公开发布)

纯度规格按批次COA提供(不公开发布)

储存条件密封、阴凉干燥处保存

运输常规化工运输

样品可协商提供

交期现货/按订单安排

供货能力：来那替尼备有现货，包装形式为按订单/批次确认(不公开发布)。我们支持对公转账并开具增值税发票，山东省内可安排快速配送，省外按物流时效发货，具体请联系 info@591daili.com。

质量与文件

每批产品随货提供 COA（分析证书）；可按需提供 MSDS/技术数据表及第三方检测报告。纯度与包装以批次 COA 及订单确认为准。

关于供应商

作为化工原料供应服务商，济南圣和化工有限公司长期服务于化工贸易、食品添加、医药中间体、日化原料等行业的采购需求。除来那替尼外，您还可以在站内按 CAS 号或产品分类检索更多品类，获取规格与报价。

常见问题

来那替尼的 CAS 号是多少？

来那替尼的 CAS 号为 698387-09-6。

该产品的纯度和包装规格是什么？

常规纯度规格为按批次COA提供(不公开发布)，包装为按订单/批次确认(不公开发布)，随货提供 COA。

来那替尼有什么用途？

主要应用于有机化学品。

如何购买或获取报价？

请发送邮件至 info@591daili.com 或通过 WhatsApp 联系，注明产品名称、CAS 号与需求数量，一个工作日内回复报价。供应商：济南圣和化工有限公司。

PubChem 公开数据

Description

Neratinib · CAS 698387-09-6 · C30H29ClN6O3. UNII JJH94R3PWB.

Identification

CAS Registry Number	698387-09-6
PubChem CID	9915743
Molecular formula	C30H29ClN6O3
IUPAC name	(E)-N-[4-[3-chloro-4-(pyridin-2-ylmethoxy)anilino]-3-cyano-7-ethoxyquinolin-6-yl]-4-(dimethylamino)but-2-enamide
UNII (FDA)	JJH94R3PWB

Computed Descriptors

Molecular Weight	557.0
XLogP3	4.9
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	8
Rotatable Bond Count	11
Exact Mass	556.1989665
Monoisotopic Mass	556.1989665
Topological Polar Surface Area	112
Heavy Atom Count	40
Formal Charge	0

Physical description & handling notes

Neratinib is a tyrosine kinase inhibitor which exhibits antitumor action against Epidermal Growth Factor Receptor (EGFR), HER2, and Human Epidermal Growth Factor Receptor 4 (HER4) postive carcinomas.

Regulatory Status

GHS notification summary	20% (1 / 5)

GHS Hazard Classification

GHS notification summary	20% (1 / 5)
Reported hazard statements	H302 (40%), H312 (40%), H315 (40%), H319 (40%), H332 (40%), H335 (20%), H360 (40%)

This chemical does not meet GHS hazard criteria for 20% (1 of 5) of reports.

H302 (40%): Harmful if swallowed [Warning Acute toxicity, oral]

Documented Uses

For use as an extended adjuvant treatment in adult patients with early stage HER2-overexpressed/amplified breast cancer, to follow adjuvant trastuzumab-based therapy.
Neratinib is an orally available tyrosine kinase receptor inhibitor that is used in the extended adjuvant therapy of early stage breast cancer. Neratinib is associated with a low rate of transient elevations in serum aminotransferase levels during therapy, but has not been convincingly linked to cases of clinically apparent liver injury with jaundice.
Breast Feeding; Lactation; Antineoplastic Agents; Enzyme Inhibitors; Protein Kinase Inhibitors; Signal Transduction Inhibitors;
Avoid grapefruit products. Grapefruit inhibits CYP3A metabolism, which may increase the serum concentration of neratinib.
Exercise caution with St. John's Wort. This herb induces CYP3A metabolism and may reduce serum levels of neratinib.
Take at the same time every day.

Synonyms

Neratinib; 698387-09-6; HKI-272; HKI 272; JJH94R3PWB; PB-272; CHEBI:61397; CDP-820; PB 272; HKI272; DTXSID70220132; N-(4-(3-Chloro-4-(2-pyridinylmethoxy)anilino)-3-cyano-7-ethoxy-6-quinolyl)-4-(dimethylamino)-2-butenamide; neratinibum; RefChem:56993; DTXCID70142623; L10XE45

Frequently Asked Questions

What are the CAS number and molecular formula of Neratinib?

CAS 698387-09-6; molecular formula C30H29ClN6O3; molecular weight — g/mol.

What other names is Neratinib known by?

Neratinib, 698387-09-6, HKI-272, HKI 272, JJH94R3PWB, PB-272.

Is Neratinib classified as hazardous?

20% of GHS notifications report no hazard classification (1 of 5).

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.