甲氯芬那酸

Description

Meclofenamic acid · CAS 644-62-2 · C14H11Cl2NO2. UNII 48I5LU4ZWD. Melting Point: 248-250; Melting Point: 257 °C; Solubility: 30.

Identification

CAS Registry Number	644-62-2
PubChem CID	4037
Molecular formula	C14H11Cl2NO2
IUPAC name	2-(2,6-dichloro-3-methylanilino)benzoic acid
UNII (FDA)	48I5LU4ZWD

Computed Descriptors

Molecular Weight	296.1
XLogP3	5.2
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	3
Exact Mass	295.0166840
Monoisotopic Mass	295.0166840
Topological Polar Surface Area	49.3
Heavy Atom Count	19
Formal Charge	0

Physical & Chemical Properties

Melting Point	248-250
Melting Point	257 °C
Solubility	30
Solubility	3.66e-03 g/L
LogP	5.9

Physical description & handling notes

• Solid
• 166.71 Ų [M+Na]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
• 155.91 Ų [M+H]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
• 169.79 Ų [M+K]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
• 150.51 Ų [M+H-H2O]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
• Meclofenamic acid is a nonsteroidal agent which has demonstrated anti-inflammatory, analgesic, and antipyretic activity in laboratory animals.

GHS Hazard Classification

Reported hazard statements	H302 (100%)

Documented Uses

• Animal Drugs -> FDA Approved Animal Drug Products (Green Book) -> Active Ingredients
• For the relief of mild to moderate pain, for the treatment of primary dysmenorrhea and for the treatment of idiopathic heavy menstrual blood loss. Also for relief of the signs and symptoms of acute and chronic rheumatoid arthritis and osteoarthritis.
• Breast Feeding; Lactation; Milk, Human; Analgesic Agents; Anti-inflammatory Agents, Nonsteroidal
• Avoid excessive or chronic alcohol consumption. Ingesting alcohol may increase the risk of developing a gastrointestinal bleed.
• Take with or without food. Taking meclofenamic acid with food reduces the rate and extent of its absorption; however it also reduces gastrointestinal upset caused by meclofenamic acid.
• Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions. They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects.

Synonyms

meclofenamic acid; meclofenamate; 644-62-2; Arquel; 2-[(2,6-dichloro-3-methylphenyl)amino]benzoic acid; Acido meclofenamico; Acide meclofenamique; INF 4668; Acidum meclofenamicum; N-(2,6-Dichloro-m-tolyl)anthranilic acid; CI-583; INF-4668; Meclomen; N-(3-Methyl-2,6-dichlorophenyl)anthranilic acid; 2-((2,6-Dichloro-3-methylphenyl)amino)benzoic acid; N-(2,6-Dichloro-3-methylphenyl)anthranilic acid

Frequently Asked Questions

What are the CAS number and molecular formula of Meclofenamic acid?

CAS 644-62-2; molecular formula C14H11Cl2NO2; molecular weight — g/mol.

What other names is Meclofenamic acid known by?

meclofenamic acid, meclofenamate, 644-62-2, Arquel, 2-[(2,6-dichloro-3-methylphenyl)amino]benzoic acid, Acido meclofenamico.

Is Meclofenamic acid classified as hazardous?

Hazard statements reported: H302.

What are the key physical properties of Meclofenamic acid?

Melting Point: 248-250; Melting Point: 257 °C; Solubility: 30; Solubility: 3.66e-03 g/L.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.