兰地洛尔

Description

Landiolol · CAS 133242-30-5 · C25H39N3O8. UNII 62NWQ924LH. Melting Point: 122-125.

Identification

CAS Registry Number	133242-30-5
PubChem CID	114905
Molecular formula	C25H39N3O8
IUPAC name	[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]methyl 3-[4-[(2S)-2-hydroxy-3-[2-(morpholine-4-carbonylamino)ethylamino]propoxy]phenyl]propanoate
UNII (FDA)	62NWQ924LH

Computed Descriptors

Molecular Weight	509.6
XLogP3	0.1
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	9
Rotatable Bond Count	14
Exact Mass	509.27371521
Monoisotopic Mass	509.27371521
Topological Polar Surface Area	128
Heavy Atom Count	36
Formal Charge	0

Physical & Chemical Properties

Melting Point	122-125

Documented Uses

• Landiolol is indicated for the short-term reduction of ventricular rate in adults with supraventricular tachycardia including atrial fibrillation and atrial flutter. It is not intended for chronic use.
• Drugs that bind to but do not activate beta-adrenergic receptors thereby blocking the actions of beta-adrenergic agonists. Adrenergic beta-antagonists are used for treatment of hypertension, cardiac arrhythmias, angina pectoris, glaucoma, migraine headaches, and anxiety.
• Agents used for the treatment or prevention of cardiac arrhythmias. They may affect the polarization-repolarization phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibers. Anti-arrhythmia agents are often classed into four main groups according to their mechanism of action: sodium channel blockade, beta-adrenergic blockade, repolarization prolongation, or calcium channel blockade.
• Established Pharmacologic Class [EPC] - beta-Adrenergic Blocker
• Mechanisms of Action [MoA] - Adrenergic beta1-Antagonists
• Landiolol is a beta-Adrenergic Blocker. The mechanism of action of landiolol is as an Adrenergic beta1-Antagonist.

Synonyms

Landiolol; 133242-30-5; ONO-1101; Ono 1101; LDLL600; 62NWQ924LH; LDLL-600; AOP200704; AOP-200704; DTXSID10158026; landiololum; RefChem:152225; DTXCID2080517; C07AB14; CID 15034750; Rapiblyk

Frequently Asked Questions

What are the CAS number and molecular formula of Landiolol?

CAS 133242-30-5; molecular formula C25H39N3O8; molecular weight — g/mol.

What other names is Landiolol known by?

Landiolol, 133242-30-5, ONO-1101, Ono 1101, LDLL600, 62NWQ924LH.

What are the key physical properties of Landiolol?

Melting Point: 122-125.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.