LDK378二盐酸盐

Name: LDK378二盐酸盐
Brand: 济南圣和化工有限公司

CAS 1380575-43-8C28H36ClN5O3SMW 558.1

LDK378二盐酸盐（CAS 1380575-43-8）属有机化学品类产品，分子式 C28H36ClN5O3S，分子量 558.1。济南圣和化工有限公司常年现货供应该产品，常规纯度按批次COA提供(不公开发布)，可按客户需求安排分装包装，欢迎邮件或来电询价。

产品概览

CAS号	1380575-43-8
分子式	C28H36ClN5O3S
分子量	558.1
LogP	6.4
纯度	按批次COA提供(不公开发布)
包装	按订单/批次确认(不公开发布)
应用领域	有机化学品
类别	有机化学品

应用领域

有机化学品

该产品的下游应用集中在有机化学品。不同客户工艺差异较大，我们支持按需提供样品与小批量试用。

包装与储存

包装规格按订单/批次确认(不公开发布)

纯度规格按批次COA提供(不公开发布)

储存条件密封、阴凉干燥处保存

运输常规化工运输

样品可协商提供

交期现货/按订单安排

采购提示：本产品按按订单/批次确认(不公开发布)起订发货，收到货物后请先核对包装完好性再行入库。储存条件为阴凉干燥、密封保存；如需 MSDS 或运输说明，可在询价时一并索取。

质量与文件

每批产品随货提供 COA（分析证书）；可按需提供 MSDS/技术数据表及第三方检测报告。纯度与包装以批次 COA 及订单确认为准。

关于供应商

济南圣和化工有限公司位于山东济南，主营化工原料供应，精选产品 3,000+ 种，覆盖有机化学品、无机化学品、食品添加剂、医药中间体等 12 大分类。我们随货提供 COA 分析证书，一个工作日内回复报价，欢迎国内外采购方长期合作。

常见问题

LDK378二盐酸盐的 CAS 号是多少？

LDK378二盐酸盐的 CAS 号为 1380575-43-8。

该产品的纯度和包装规格是什么？

常规纯度规格为按批次COA提供(不公开发布)，包装为按订单/批次确认(不公开发布)，随货提供 COA。

LDK378二盐酸盐有什么用途？

主要应用于有机化学品。

如何购买或获取报价？

请发送邮件至 info@591daili.com 或通过 WhatsApp 联系，注明产品名称、CAS 号与需求数量，一个工作日内回复报价。供应商：济南圣和化工有限公司。

PubChem 公开数据

Description

LDK378 dihydrochloride · CAS 1380575-43-8 · C28H36ClN5O3S. UNII K418KG2GET.

Identification

CAS Registry Number	1380575-43-8
PubChem CID	57379345
Molecular formula	C28H36ClN5O3S
IUPAC name	5-chloro-2-N-(5-methyl-4-piperidin-4-yl-2-propan-2-yloxyphenyl)-4-N-(2-propan-2-ylsulfonylphenyl)pyrimidine-2,4-diamine
UNII (FDA)	K418KG2GET

Computed Descriptors

Molecular Weight	558.1
XLogP3	6.4
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	8
Rotatable Bond Count	9
Exact Mass	557.2227389
Monoisotopic Mass	557.2227389
Topological Polar Surface Area	114
Heavy Atom Count	38
Formal Charge	0

Physical description & handling notes

9.7 and 4.1

GHS Hazard Classification

Reported hazard statements	H302 (33.3%), H360 (16.7%), H372 (66.7%), H400 (16.7%), H410 (66.7%)

H302 (33.3%): Harmful if swallowed [Warning Acute toxicity, oral]

H360 (16.7%): May damage fertility or the unborn child [Danger Reproductive toxicity]

Documented Uses

Ceritinib is a small molecule tyrosine kinase receptor inhibitor and antineoplastic agent that is used in the therapy of selected forms of advanced non-small cell lung cancer (NSCLC). Ceritinib is associated with a moderate rate of serum aminotransferase elevations during therapy and rare instances of clinically apparent acute liver injury.
Breast Feeding; Lactation; Milk, Human; Antineoplastic Agents; Enzyme Inhibitors; Protein Kinase Inhibitors; Signal Transduction Inhibitors; Tyrosine Kinase Inhibitors
Ceritinib is approved to treat:
• Non-small cell lung cancer that is ALK positive and has metastasized (spread to other parts of the body). It is used in adults.
Ceritinib is also being studied in the treatment of other types of cancer.
Avoid grapefruit products. Grapefruit inhibits the CYP3A metabolism of ceritinib, which may increase its serum concentration.

Synonyms

ceritinib; 1032900-25-6; LDK378; ZYKADIA; LDK-378; NVP-LDK378-NX; LDK 378; K418KG2GET; ceritinibum; NVP-LDK-378-NX; CHEBI:78432; DTXSID10725373; RefChem:57924; DTXCID50676118; L01XE28; 811-457-8

Frequently Asked Questions

What are the CAS number and molecular formula of LDK378 dihydrochloride?

CAS 1380575-43-8; molecular formula C28H36ClN5O3S; molecular weight — g/mol.

What other names is LDK378 dihydrochloride known by?

ceritinib, 1032900-25-6, LDK378, ZYKADIA, LDK-378, NVP-LDK378-NX.

Is LDK378 dihydrochloride classified as hazardous?

Hazard statements reported: H302, H360, H372, H400, H410.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.