厄比尼替尼

Description

Irbinitinib · CAS 937263-43-9 · C26H24N8O2. UNII 234248D0HH. Melting Point: 230; LogP: 3.62.

Identification

CAS Registry Number	937263-43-9
PubChem CID	51039094
Molecular formula	C26H24N8O2
IUPAC name	6-N-(4,4-dimethyl-5H-1,3-oxazol-2-yl)-4-N-[3-methyl-4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)phenyl]quinazoline-4,6-diamine
UNII (FDA)	234248D0HH

Computed Descriptors

Molecular Weight	480.5
XLogP3	4
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	8
Rotatable Bond Count	6
Exact Mass	480.20222204
Monoisotopic Mass	480.20222204
Topological Polar Surface Area	111
Heavy Atom Count	36
Formal Charge	0

Physical & Chemical Properties

Melting Point	230
LogP	3.62

Physical description & handling notes

• By inhibiting tyrosine kinase, tucatinib exerts anti-tumor activity, reducing the size of HER-2 positive breast cancer tumors. In clinical trials, the regimen of tucatinib and [trastuzumab] showed enhanced activity both in vitro and in vivo when compared to either drug administered by itself.

Documented Uses

• Tucatinib is tyrosine kinase inhibitor that targets the human epidermal growth factor receptor 2 (HER2) and is used in combination with other antineoplastic agents in the treatment of refractory, advanced or metastatic HER2 positive breast and colorectal cancer. Serum aminotransferase elevations are common during therapy with tucatinib, but it has not been linked to episodes of clinically apparent liver injury with jaundice.
• Breast Feeding; Lactation; Antineoplastic Agents; Enzyme Inhibitors; Protein Kinase Inhibitors; Signal Transduction Inhibitors; Tyrosine Kinase Inhibitors
• Tucatinib is approved to treat adults whose cancer is HER2 positive, including:
• • Breast cancer that cannot be removed by surgery or has spread to other parts of the body, such as the brain. It is used with trastuzumab and capecitabine in patients who have received at least one anti-HER2 treatment for cancer that has spread to other parts of the body.
• • Colorectal cancer that cannot be removed by surgery or has spread to other parts of the body and has the wild-typeRAS gene. It is used with trastuzumab in patients who have received treatment that included a fluoropyrimidine, oxaliplatin, and irinotecan hydrochloride and it did not work or is no longer working.¹
• ¹This use is approved under FDA’s Accelerated Approval Program. As a condition of approval, a confirmatory trial(s) must show that tucatinib provides a clinical benefit in these patients.Tucatinib is also being studied in the treatment of other types of cancer.

Synonyms

Tucatinib; Irbinitinib; 937263-43-9; Tukysa; ONT-380; 234248D0HH; MK-7119; DTXSID601027958; tucatinibum; RefChem:58754; DTXCID801513525; 6-DIAMINE; UNII-234248D0HH; BDBM471617; Irbinitinib; ARRY-380; ONT-380; CS-3906

Frequently Asked Questions

What are the CAS number and molecular formula of Irbinitinib?

CAS 937263-43-9; molecular formula C26H24N8O2; molecular weight — g/mol.

What other names is Irbinitinib known by?

Tucatinib, Irbinitinib, 937263-43-9, Tukysa, ONT-380, 234248D0HH.

What are the key physical properties of Irbinitinib?

Melting Point: 230; LogP: 3.62.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.