isradipine

Description

isradipine · CAS 75695-93-1 · C19H21N3O5. UNII YO1UK1S598. Melting Point: 168-170 °C; Melting Point: 168 - 170 °C; Solubility: 2.28e-01 g/L.

Identification

CAS Registry Number	75695-93-1
PubChem CID	3784
Molecular formula	C19H21N3O5
IUPAC name	3-O-methyl 5-O-propan-2-yl 4-(2,1,3-benzoxadiazol-4-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
UNII (FDA)	YO1UK1S598

Computed Descriptors

Molecular Weight	371.4
XLogP3	4.3
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	8
Rotatable Bond Count	6
Exact Mass	371.14812078
Monoisotopic Mass	371.14812078
Topological Polar Surface Area	104
Heavy Atom Count	27
Formal Charge	0

Physical & Chemical Properties

Melting Point	168-170 °C
Melting Point	168 - 170 °C
Solubility	2.28e-01 g/L
LogP	4.28
LogP	2.901

Physical description & handling notes

• Solid
• Practically insoluble (< 10 mg/L at 37 °C)

GHS Hazard Classification

Reported hazard statements	H301 (98%), H319 (92.2%), H372 (92.2%), H400 (98%), H410 (98%)

Documented Uses

• Use (kg; approx.) in Germany (2009): >10
• Consumption (g per capita; approx.) in Germany (2009): 0.000122
• For the management of mild to moderate essential hypertension. It may be used alone or concurrently with thiazide-type diuretics.
• Isradipine is a second generation calcium channel blocker that is used to treat hypertension. Isradipine is associated with a low rate of serum enzyme elevations during therapy, but has not been linked convincingly to instances of clinically apparent liver injury.
• Breast Feeding; Lactation; Antihypertensive Agents; Calcium Channel Blockers; Vasodilator Agents;
• Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS.

Synonyms

isradipine; 75695-93-1; DynaCirc; Lomir; Prescal; Dynacirc CR; PN 200-110; Isradipino; PN-200-110; Isradipinum; DTXSID4023179; NSC-759892; YO1UK1S598; 3,5-Pyridinedicarboxylic acid, 4-(4-benzofurazanyl)-1,4-dihydro-2,6-dimethyl-, methyl 1-methylethyl ester; DTXCID203179; O5-methyl O3-propan-2-yl 4-(2,1,3-benzoxadiazol-7-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate

Frequently Asked Questions

What are the CAS number and molecular formula of isradipine?

CAS 75695-93-1; molecular formula C19H21N3O5; molecular weight — g/mol.

What other names is isradipine known by?

isradipine, 75695-93-1, DynaCirc, Lomir, Prescal, Dynacirc CR.

Is isradipine classified as hazardous?

Hazard statements reported: H301, H319, H372, H400, H410.

What are the key physical properties of isradipine?

Melting Point: 168-170 °C; Melting Point: 168 - 170 °C; Solubility: 2.28e-01 g/L; LogP: 4.28.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.