丙咪嗪

Description

imipramine · CAS 50-49-7 · C19H24N2. UNII OGG85SX4E4. Boiling Point: 160; Boiling Point: 160 °C @ 0.1 MM HG; Melting Point: 174-175.

Identification

CAS Registry Number	50-49-7
PubChem CID	3696
Molecular formula	C19H24N2
IUPAC name	3-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)-N,N-dimethylpropan-1-amine
UNII (FDA)	OGG85SX4E4

Computed Descriptors

Molecular Weight	280.4
XLogP3	4.8
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	4
Exact Mass	280.193948774
Monoisotopic Mass	280.193948774
Topological Polar Surface Area	6.5
Heavy Atom Count	21
Formal Charge	0

Physical & Chemical Properties

Boiling Point	160
Boiling Point	160 °C @ 0.1 MM HG
Melting Point	174-175
Melting Point	174.5 °C
Solubility	18.2
Solubility	In water, 18.2 mg/l @ 24 °C.
Solubility	18.2 mg/L at 24 °C
LogP	4.8
LogP	log Kow = 4.80
LogP	4.80

Physical description & handling notes

• Solid
• White to off-white /hydrochloride/
• Odorless /hydrochloride/
• CRYSTALS FROM ACETONE; FREELY SOL IN WATER, LESS SOL IN ALCOHOL, SPARINGLY SOL IN ACETONE /HYDROCHLORIDE/
• When heated to decomposition it emits toxic fumes of nitroxides.
• 172.7 Ų [M+Na]+ [CCS Type: DT; Buffer gas: N2; Ionization: ESI+; Dataset: TOXCAST; Source Identifier: DTXSID7040738]

Regulatory Status

GHS notification summary	75% (6 / 8)

GHS Hazard Classification

GHS notification summary	75% (6 / 8)
Reported hazard statements	H302 (12.5%), H400 (12.5%)

Documented Uses

• Medication: antidepressant agent /hydrochloride/
• Use (kg; approx.) in Germany (2009): >250
• Consumption (g per capita; approx.) in Germany (2009): 0.00305
• Consumption (g per capita) in the USA (2002): 0.0146
• For the relief of symptoms of depression and as temporary adjunctive therapy in reducing enuresis in children aged 6 years and older. May also be used to manage panic disorders, with or without agoraphobia, as a second line agent in ADHD, management of eating disorders, for short-term management of acute depressive episodes in bipolar disorder and schizophrenia, and for symptomatic treatment of postherpetic neuralgia.
• HAEFLIGER, SCHINDLER, US PATENT 2,554,736 (1951 TO GEIGY); HAEFLIGER, SCHINDLER HELV CHIM ACTA 37, 472 (1954).

Synonyms

imipramine; 50-49-7; Melipramine; Antideprin; Berkomine; Imidobenzyle; Dimipressin; Melipramin; Dynaprin; Intalpram; Nelipramin; Timolet; Irmin; Dpid; Dyna-zina; Impramine

Frequently Asked Questions

What are the CAS number and molecular formula of imipramine?

CAS 50-49-7; molecular formula C19H24N2; molecular weight — g/mol.

What other names is imipramine known by?

imipramine, 50-49-7, Melipramine, Antideprin, Berkomine, Imidobenzyle.

Is imipramine classified as hazardous?

75% of GHS notifications report no hazard classification (6 of 8).

What are the key physical properties of imipramine?

Boiling Point: 160; Boiling Point: 160 °C @ 0.1 MM HG; Melting Point: 174-175; Melting Point: 174.5 °C.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.