异环磷酰胺

Description

Ifosfamide · CAS 3778-73-2 · C7H15Cl2N2O2P. UNII UM20QQM95Y. Melting Point: 39-41 °C; Melting Point: 39 - 41 °C; Solubility: 3780.

Identification

CAS Registry Number	3778-73-2
PubChem CID	3690
Molecular formula	C7H15Cl2N2O2P
IUPAC name	N,3-bis(2-chloroethyl)-2-oxo-1,3,2λ5-oxazaphosphinan-2-amine
UNII (FDA)	UM20QQM95Y

Computed Descriptors

Molecular Weight	261.08
XLogP3	0.9
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	5
Exact Mass	260.0248201
Monoisotopic Mass	260.0248201
Topological Polar Surface Area	41.6
Heavy Atom Count	14
Formal Charge	0

Physical & Chemical Properties

Melting Point	39-41 °C
Melting Point	39 - 41 °C
Solubility	3780
Solubility	1.50e+01 g/L
LogP	0.86
LogP	log Kow = 0.86
LogP	0.8

Physical description & handling notes

• Solid
• Crystals from anhyd ether
• White crystalline powder
• Soluble in water
• The constituted soln is stated to be chemically & physically stable for 7 days at 30 °C & for 3-6 wk under refrigeration. Because of microbiological concerns, the manufacturer recommends storage under refrigeration & use in 6 hr for ifosfamide not constituted with bacteriostatic water for injection.
• When heated to decomposition it emits very toxic fumes of /hydrogen chloride, nitrogen oxides, & phosphorus oxides/.

GHS Hazard Classification

Reported hazard statements	H301 (98.9%), H319 (97.9%)

Documented Uses

• Has shown promising results in refractory pediatric bone and soft tissue sarcomas, refractory testicular tumors, and Wilms' tumor in children.
• Use (kg) in Switzerland (2009): >10
• Use (kg; approx.) in Germany (2009): >100
• Use (kg; exact) in Germany (2009): 151
• Consumption (g per capita) in Switzerland (2009): 0.0013
• Consumption (g per capita; approx.) in Germany (2009): 0.0012

Synonyms

ifosfamide; 3778-73-2; Isophosphamide; Iphosphamide; Isofosfamide; Ifex; Ifosfamid; Isoendoxan; Iphosphamid; Holoxan; Mitoxana; Naxamide; Cyfos; I-Phosphamide; Ifsofamide; ASTA Z 4942

Frequently Asked Questions

What are the CAS number and molecular formula of Ifosfamide?

CAS 3778-73-2; molecular formula C7H15Cl2N2O2P; molecular weight — g/mol.

What other names is Ifosfamide known by?

ifosfamide, 3778-73-2, Isophosphamide, Iphosphamide, Isofosfamide, Ifex.

Is Ifosfamide classified as hazardous?

Hazard statements reported: H301, H319.

What are the key physical properties of Ifosfamide?

Melting Point: 39-41 °C; Melting Point: 39 - 41 °C; Solubility: 3780; Solubility: 1.50e+01 g/L.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.