Fosthiazate

Description

Fosthiazate · CAS 98886-44-3 · C9H18NO3PS2. UNII 96QJ4O095U. Solubility: In water, 9.85X10+3 mg/L at 20 °C; Density: 1.234 at 20 °C; Vapor Pressure: 4.20X10-6 mm Hg at 25 °C.

Identification

CAS Registry Number	98886-44-3
PubChem CID	91758
Molecular formula	C9H18NO3PS2
IUPAC name	3-[butan-2-ylsulfanyl(ethoxy)phosphoryl]-1,3-thiazolidin-2-one
UNII (FDA)	96QJ4O095U

Computed Descriptors

Molecular Weight	283.4
XLogP3	2
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	6
Exact Mass	283.04657278
Monoisotopic Mass	283.04657278
Topological Polar Surface Area	97.2
Heavy Atom Count	16
Formal Charge	0

Physical & Chemical Properties

Solubility	In water, 9.85X10+3 mg/L at 20 °C
Density	1.234 at 20 °C
Vapor Pressure	4.20X10-6 mm Hg at 25 °C
LogP	log Kow = 1.68
LogP	1.68
Stability/Shelf Life	In water, DT50 3 days (pH 9, 25 °C)

Physical description & handling notes

• Pale yellow oil
• Clear, colorless liquid
• In n-hexane 15.14 g/L at 20 °C; miscible with xylene, N-methylpyrrolidone and isopropyl alcohol
• Henry's Law constant = 1.76X10-5 Pa-cu m/mol /1.74X10-10 atm-cu m/mol/ at 25 °C
• Stable under normal conditions. /Nemathorin 10G/
• Index of refraction: 1.5334 at 19.6 °C/D

GHS Hazard Classification

Reported hazard statements	H301, H312, H317, H331, H400, H410, H311, H336

Documented Uses

• Fosthiazate is produced by treating 2-oxo-3-thiazolidine with S-sec-butyl O-ethyl phosphorochloridothioate in toluene.
• Substances used in the treatment or control of nematode infestations. They are used also in veterinary practice.
• Chemicals used to destroy pests of any sort. The concept includes fungicides (FUNGICIDES, INDUSTRIAL); INSECTICIDES; RODENTICIDES; etc.
• Paraoxonase (PON1) is a key enzyme in the metabolism of organophosphates. PON1 can inactivate some organophosphates through hydrolysis. PON1 hydrolyzes the active metabolites in several organophosphates insecticides as well as, nerve agents such as soman, sarin, and VX. The presence of PON1 polymorphisms causes there to be different enzyme levels and catalytic efficiency of this esterase, which in turn suggests that different individuals may be more susceptible to the toxic effect of OP exposure.
• Groups of 5 Crl:CD BR VAF/Plus rats/sex per group were dosed once by gavage (in 2 mL/kg corn oil vehicle) with fosthiazate, either 2 or 20 mg/kg. Unlabeled fosthiazate was 99% pure, and ringlabeled fosthiazate was >99% pure. ... Median initial half-life estimates (defined as peak blood concentration time to 12 hrs post-dosing) were 14.9 or 11.5 hrs for low dose males and females, respectively. High dose initial half-life estimates were 8.6 hrs for both males and females. Median half-life values for the later phase

Synonyms

Fosthiazate; 98886-44-3; Nemathorin; DTXSID0034930; (RS)-S-sec-butyl-O-ethyl-2-oxo-1,3-thiazolidin-3-ylphosphonothioate; 3-[butan-2-ylsulfanyl(ethoxy)phosphoryl]-1,3-thiazolidin-2-one; O-Ethyl S-(1-methylpropyl) (2-oxo-3-thiazolidinyl)phosphonothioate; 96QJ4O095U; DTXCID8014930; CHEBI:38692; ethyl (butan-2-ylsulfanyl)(2-oxo-1,3-thiazolidin-3-yl)phosphinate; O-ethyl S-(butan-2-yl) (2-oxo-1,3-thiazolidin-3-yl)phosphonothioate; 3-(butan-2-ylsulfanyl(ethoxy)phosphoryl)-1,3-thiazolidin-2-one; RefChem:600361; Phosphonothioic acid, P-(2-oxo-3-thiazolidinyl)-, O-ethyl S-(1-methylpropyl) ester; 619-377-3

Frequently Asked Questions

What are the CAS number and molecular formula of Fosthiazate?

CAS 98886-44-3; molecular formula C9H18NO3PS2; molecular weight — g/mol.

What other names is Fosthiazate known by?

Fosthiazate, 98886-44-3, Nemathorin, DTXSID0034930, (RS)-S-sec-butyl-O-ethyl-2-oxo-1,3-thiazolidin-3-ylphosphonothioate, 3-[butan-2-ylsulfanyl(ethoxy)phosphoryl]-1,3-thiazolidin-2-one.

Is Fosthiazate classified as hazardous?

Hazard statements reported: H301, H312, H317, H331, H400.

What are the key physical properties of Fosthiazate?

Solubility: In water, 9.85X10+3 mg/L at 20 °C; Density: 1.234 at 20 °C; Vapor Pressure: 4.20X10-6 mm Hg at 25 °C; LogP: log Kow = 1.68.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.