氟伐他汀钠

Description

FLUVASTATIN SODIUM · CAS 93957-55-2 · C24H26FNO4. UNII 4L066368AS. Melting Point: 194-197 °C; Melting Point: 194 - 197 °C; Solubility: 0.46.

Identification

CAS Registry Number	93957-55-2
PubChem CID	1548972
Molecular formula	C24H26FNO4
IUPAC name	(E,3S,5R)-7-[3-(4-fluorophenyl)-1-propan-2-ylindol-2-yl]-3,5-dihydroxyhept-6-enoic acid
UNII (FDA)	4L066368AS

Computed Descriptors

Molecular Weight	411.5
XLogP3	3.5
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	8
Exact Mass	411.18458647
Monoisotopic Mass	411.18458647
Topological Polar Surface Area	82.7
Heavy Atom Count	30
Formal Charge	0

Physical & Chemical Properties

Melting Point	194-197 °C
Melting Point	194 - 197 °C
Solubility	0.46
Solubility	4.41e-03 g/L
LogP	4.5
LogP	3.92
Dissociation Constants	4.31

Physical description & handling notes

• Solid
• MW: 433.46. White to pale yellow powder. Hygroscopic. MP: 194-197 °C. Soluble in water, ethanol, methanol /Fluvastatin sodium salt/
• Stable under recommended storage conditions. /Fluvastatin sodium hydrate/
• Hazardous decomposition products formed under fire conditions - Carbon oxides, nitrogen oxides (NOx), hydrogen fluoride, sodium oxides. /Fluvastatin sodium hydrate/
• 200.0 Ų [M-H]- [CCS Type: DT; Buffer gas: N2; Ionization: ESI-; Dataset: TOXCAST; Source Identifier: DTXSID2020636]
• Table: Fluvastatin Sodium Preparations [Table#8394]

GHS Hazard Classification

Reported hazard statements	H302 (100%), H351 (100%), H315 (100%), H318 (100%), H412 (100%)

Documented Uses

• Anticholesteremic Agents; Hydroxymethylglutaryl-CoA Reductase Inhibitors
• Use (kg; approx.) in Germany (2009): >2500
• Consumption (g per capita; approx.) in Germany (2009): 0.0305
• Consumption (g per capita) in the USA (2002): 0.0295
• Preparation: F.G. Kathawala, World Intellectual Property Organization patent 8402131; idem, United States of America patent 4739073 (1984, 1988 both to Sandoz).
• To be used as an adjunct to dietary therapy to prevent cardiovascular events. May be used as secondary prevention in patients with coronary heart disease (CHD) to reduce the risk of requiring coronary revascularization procedures, for reducing progression of coronary atherosclerosis in hypercholesterolemic patients with CHD, and for the treatment of primary hypercholesterolemia and mixed dyslidipidemia.

Synonyms

fluvastatin; Fluvastatine; 93957-54-1; Fluvastatina; Fluvastatinum; CHEBI:5136; XU-62320; 4L066368AS; XU 62320; Fluvas; (3S,5R,6E)-7-[3-(4-fluorophenyl)-1-(propan-2-yl)-1H-indol-2-yl]-3,5-dihydroxyhept-6-enoic acid; CHEBI:38561; DTXSID2020636; NSC-758896; 6-HEPTENOIC ACID, 7-(3-(4-FLUOROPHENYL)-1-(1-METHYLETHYL)-1H-INDOL-2-YL)-3,5-DIHYDROXY-, (3R,5S,6E)-REL-; DTXCID0065309

Frequently Asked Questions

What are the CAS number and molecular formula of FLUVASTATIN SODIUM?

CAS 93957-55-2; molecular formula C24H26FNO4; molecular weight — g/mol.

What other names is FLUVASTATIN SODIUM known by?

fluvastatin, Fluvastatine, 93957-54-1, Fluvastatina, Fluvastatinum, CHEBI:5136.

Is FLUVASTATIN SODIUM classified as hazardous?

Hazard statements reported: H302, H351, H315, H318, H412.

What are the key physical properties of FLUVASTATIN SODIUM?

Melting Point: 194-197 °C; Melting Point: 194 - 197 °C; Solubility: 0.46; Solubility: 4.41e-03 g/L.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.