5-Bromo-2'-Deoxyuridine (CAS 59-14-3) — formula C9H11BrN2O5, molecular weight 307.10; category organic chemicals.
5-Bromo-2'-Deoxyuridine (CAS 59-14-3) is a chemical raw material in the organic chemicals category. Its molecular formula C9H11BrN2O5 comprises 9 C, 11 H, 1 Br, 2 N, 5 O atoms. Its molecular weight is about 307.10. Reported physicochemical data: melting point around 365 to 369 °F (NTP, 1992), LogP about log Kow = -0.29. As a sourcing and distribution partner we help locate and compare this item across domestic and cross-border channels, arranging samples and batch orders with full COA and compliance files.
| CAS Number | 59-14-3 |
|---|---|
| Molecular Formula | C9H11BrN2O5 |
| Molecular Weight | 307.10 |
| Melting Point | 365 to 369 °F (NTP, 1992) |
| LogP | log Kow = -0.29 |
| Applications | A drug that makes cancer cells more sensitive to radiation and is also used as a diagnostic agent to determine how fast cancer cells grow, A nucleoside that substitutes for thymidine in DNA and thus acts as an antimetabolite. It causes breaks in chromosomes and has been proposed as an antiviral and antineoplastic agent. It has been given orphan drug status for use in the treatment of primary brain tumors, A thymidine analog that incorporates /into/ DNA of dividing cells during the S-phase of the cell cycle. ... However, BrdU is not a marker of the S-phase of the cell cycle. As a thymidine analog, it is a marker of DNA synthesis. BrdU immunohistochemistry has been instrumental for the study of the development of the nervous system, and to confirm that neurogenesis occurs in the adult mammalian brain |
| Category | Organic Chemicals |
Documented applications: A drug that makes cancer cells more sensitive to radiation and is also used as a diagnostic agent to determine how fast cancer cells grow, A nucleoside that substitutes for thymidine in DNA and thus acts as an antimetabolite. It causes breaks in chromosomes and has been proposed as an antiviral and antineoplastic agent. It has been given orphan drug status for use in the treatment of primary brain tumors, A thymidine analog that incorporates /into/ DNA of dividing cells during the S-phase of the cell cycle. ... However, BrdU is not a marker of the S-phase of the cell cycle. As a thymidine analog, it is a marker of DNA synthesis. BrdU immunohistochemistry has been instrumental for the study of the development of the nervous system, and to confirm that neurogenesis occurs in the adult mammalian brain.
5-Bromo-2'-Deoxyuridine is a carbon-based organic compound with CAS registry number 59-14-3 and molecular formula C9H11BrN2O5 (molecular weight 307.10), belonging to the organic chemicals segment of chemical raw materials.
CAS number: 59-14-3
Its molecular formula C9H11BrN2O5 comprises 9 C, 11 H, 1 Br, 2 N, 5 O atoms.
Also known as: 5-Bromo-2'-Deoxyuridine · 5-溴-2'-脱氧尿苷
Category: organic chemicals
The CAS registry number of 5-Bromo-2'-Deoxyuridine is 59-14-3.
Molecular formula C9H11BrN2O5, molecular weight 307.10.
It is also registered under: 5-Bromo-2'-Deoxyuridine, 5-溴-2'-脱氧尿苷.
Recorded applications: A drug that makes cancer cells more sensitive to radiation and is also used as a diagnostic agent to determine how fast cancer cells grow, A nucleoside that substitutes for thymidine in DNA and thus acts as an antimetabolite. It causes breaks in chromosomes and has been proposed as an antiviral and antineoplastic agent. It has been given orphan drug status for use in the treatment of primary brain tumors, A thymidine analog that incorporates /into/ DNA of dividing cells during the S-phase of the cell cycle. ... However, BrdU is not a marker of the S-phase of the cell cycle. As a thymidine analog, it is a marker of DNA synthesis. BrdU immunohistochemistry has been instrumental for the study of the development of the nervous system, and to confirm that neurogenesis occurs in the adult mammalian brain.
Category: Organic Chemicals.
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Independent reference data for 5-Bromo-2'-Deoxyuridine (CAS 59-14-3), compiled from public chemistry databases.
| CAS Registry Number | 59-14-3 |
|---|---|
| PubChem CID | 6035 |
| Molecular formula | C9H11BrN2O5 |
| IUPAC name | 5-bromo-1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione |
| UNII (FDA) | G34N38R2N1 |
| Molecular Weight | 307.10 |
|---|---|
| XLogP3 | -0.3 |
| Hydrogen Bond Donor Count | 3 |
| Hydrogen Bond Acceptor Count | 5 |
| Rotatable Bond Count | 2 |
| Exact Mass | 305.98513 |
| Monoisotopic Mass | 305.98513 |
| Topological Polar Surface Area | 99.1 |
| Heavy Atom Count | 17 |
| Melting Point | 365 to 369 °F (NTP, 1992) |
|---|---|
| Melting Point | 187-189 °C |
| Solubility | 10 to 50 mg/mL at 72 °F (NTP, 1992) |
| Solubility | Water 10 - 20 (mg/mL) |
| Solubility | 1 N NaOH > 400 (mg/mL) |
| Solubility | Acetone ~ 4 (mg/mL) |
| LogP | log Kow = -0.29 |
| LogP | -0.29 |
5-BROMO-2'-DEOXYURIDINE; 59-14-3; Broxuridine; Bromodeoxyuridine; 5-Bromodeoxyuridine; BRDU; BUDR; 5-Bromo-2-deoxyuridine; Radibud; Broxuridina; 5-Bdu; 5-Bromouracil deoxyriboside; Bromouracil deoxyriboside; 5-Bromodesoxyuridine; Broxuridinum; 5-Bromouracil-2-deoxyriboside
| Reported hazard statements | H340 (83.3%), H341 (13%), H361 (79.6%) |
|---|
H340 (83.3%): May cause genetic defects [Danger Germ cell mutagenicity]
H341 (13%): Suspected of causing genetic defects [Warning Germ cell mutagenicity]
5-Bromo-2'-Deoxyuridine · CAS 59-14-3 · C9H11BrN2O5. UNII G34N38R2N1. Melting Point: 365 to 369 °F (NTP, 1992); Melting Point: 187-189 °C; Solubility: 10 to 50 mg/mL at 72 °F (NTP, 1992).
Source: PubChem / Wikidata; the batch COA governs where values differ.
Supplier: Jinan Shenghe Chemical Co., Ltd.
中文页面: 5-溴-2'-脱氧尿苷