利血平

Description

Reserpine · CAS 50-55-5 · C33H40N2O9. UNII 8B1QWR724A. Melting Point: 264.5; Melting Point: 264.5 °C; Solubility: 73.

Identification

CAS Registry Number	50-55-5
PubChem CID	5770
Molecular formula	C33H40N2O9
IUPAC name	methyl (1R,15S,17R,18R,19S,20S)-6,18-dimethoxy-17-(3,4,5-trimethoxybenzoyl)oxy-1,3,11,12,14,15,16,17,18,19,20,21-dodecahydroyohimban-19-carboxylate
UNII (FDA)	8B1QWR724A

Computed Descriptors

Molecular Weight	608.7
XLogP3	4
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	10
Rotatable Bond Count	10
Exact Mass	608.27338086
Monoisotopic Mass	608.27338086
Topological Polar Surface Area	118
Heavy Atom Count	44
Formal Charge	0

Physical & Chemical Properties

Melting Point	264.5
Melting Point	264.5 °C
Solubility	73
Solubility	In water, 73 mg/l @ 30 °C
Solubility	1.13e-02 g/L
LogP	3.2
Ionization Efficiency	4.66
Ionization Efficiency	2.7
Ionization Efficiency	MeCN (80%)
Ionization Efficiency	DOI:10.1002/rcm.8545

Physical description & handling notes

• Reserpine appears as white or cream to slightly yellow crystals or crystalline powder. Odorless with a bitter taste. (NTP, 1992)
• Solid
• White or pale buff to slightly yellowish powder
• Long prisms from dil acetone
• Odorless
• 507 to 509 °F (decomposes) (NTP, 1992)

GHS Hazard Classification

Reported hazard statements	H302 (100%)

Documented Uses

• Antihypertensive, central depressant, and sedative drug for both humans and animals.
• Therap cat (Vet): Hypotensive, tranquilizer. Has been used to prevent aortic rupture in turkeys.
• Foe the treatment of hypertension
• Pharmaceuticals -> Animal Drugs -> Approved in Taiwan
• Isolation from roots of Rauwolfia serpentina L Benth, Apocynaceae: Dorfman et al, Helv Chim Acta 37, 59 (1954); Schwyzer, Mueller, US patent 2,833,771 (1958 to Ciba). Structure: Dorfman et al, Loc cit; Neuss et al, J Am Chem Soc 76, 2463 (1954). ... synthesis: Woodward et al, J Am Chem Soc 78, 2023 (1956).
• Powdered Rauwolfia serpentia contains several alkaloids. Lactose, starch, or Rauwolfia serpentia containing a higher alkaloid content is added to the commercially available product so that it contains 0.15-0.20% of the reserpine-rescinnamine group alkaloids, calculated as reserpine.

Synonyms

reserpine; 50-55-5; Serpalan; Serpasil; Apoplon; Sandril; Serpivite; Alserin; Rau-Sed; (-)-Reserpine; Deserpine; Elserpine; Eskaserp; Hiserpia; Raunervil; Raupasil

Frequently Asked Questions

What are the CAS number and molecular formula of Reserpine?

CAS 50-55-5; molecular formula C33H40N2O9; molecular weight — g/mol.

What other names is Reserpine known by?

reserpine, 50-55-5, Serpalan, Serpasil, Apoplon, Sandril.

Is Reserpine classified as hazardous?

Hazard statements reported: H302.

What are the key physical properties of Reserpine?

Melting Point: 264.5; Melting Point: 264.5 °C; Solubility: 73; Solubility: In water, 73 mg/l @ 30 °C.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.