甲灭酸

Description

mefenamic acid · CAS 61-68-7 · C15H15NO2. UNII 367589PJ2C. Melting Point: 230-231 °C; Melting Point: 230 - 231 °C; Solubility: 20.

Identification

CAS Registry Number	61-68-7
PubChem CID	4044
Molecular formula	C15H15NO2
IUPAC name	2-(2,3-dimethylanilino)benzoic acid
UNII (FDA)	367589PJ2C

Computed Descriptors

Molecular Weight	241.28
XLogP3	5.1
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	3
Exact Mass	241.110278721
Monoisotopic Mass	241.110278721
Topological Polar Surface Area	49.3
Heavy Atom Count	18
Formal Charge	0

Physical & Chemical Properties

Melting Point	230-231 °C
Melting Point	230 - 231 °C
Solubility	20
Solubility	1.37e-02 g/L
LogP	5.12
LogP	4.2
LogP	4.38
Dissociation Constants	4.2
Dissociation Constants	4.5
Dissociation Constants	PKA 4.2

Physical description & handling notes

• Solid
• CRYSTALS
• WHITE TO OFF-WHITE, CRYSTALLINE POWDER
• DECARBOXYLATES @ TEMP ABOVE ITS MELTING POINT (@ 300 °C, 100% IS DECARBOXYLATED IN 3 MIN)
• WHITE POWDER; SOLUBILITY IN WATER: GREATER THAN 5 G/100 ML /SODIUM SALT/
• IN WATER @ PH 7.1: 0.0041 G/100 ML @ 25 °C, 0.008 G/100 ML @ 37 °C; SOL IN SOLN OF ALKALI HYDROXIDES; SPARINGLY SOL IN ETHER, CHLOROFORM; SLIGHTLY SOL IN ETHANOL

Regulatory Status

GHS notification summary	0.8% (1 / 126)

GHS Hazard Classification

GHS notification summary	0.8% (1 / 126)
Reported hazard statements	H302 (99.2%), H361 (23.8%), H362, H370, H371, H372

Documented Uses

• Use (kg) in Switzerland (2009): >10000
• Consumption (g per capita) in Switzerland (2009): 1.3
• PREPD BY COPPER-CATALYZED CONDENSATION OF O-CHLOROBENZOIC ACID & 2,3-DIMETHYLANILINE: WINDER...J PHARMACOL EXP THER 138, 405 (1962); BELG PATENT 605,302 (1961 TO PARKE, DAVIS).
• O-CHLOROBENOZIC ACID IS CONDENSED WITH 2,3-XYLIDENE WITH AID OF POTASSIUM CARBONATE & RESULTING POTASSIUM SALT IS TREATED WITH MINERAL ACID TO LIBERATE DESIRED ACID. US PATENT 3,138,636.
• MEFENAMIC ACID IS DERIVATIVE OF ANTHRANILIC ACID, AMINE ANALOG OF SALICYLIC ACID. IT IS ONLY FENAMATE AVAIL FOR CLINICAL USE IN US, BUT IT WAS RELEASED IN 1967 ONLY FOR RESTRICTED USE AS ANALGESIC. ...TOXICITY OF MEFENAMIC ACID TENDS TO DISCOURAGE INTEREST IN GROUP.
• For the treatment of rheumatoid arthritis, osteoarthritis, dysmenorrhea, and mild to moderate pain, inflammation, and fever.

Synonyms

mefenamic acid; 61-68-7; Ponstel; 2-[(2,3-dimethylphenyl)amino]benzoic acid; Mephenamic acid; 2-((2,3-Dimethylphenyl)amino)benzoic acid; Mephenaminic acid; Ponstan; Methenamic acid; Vialidon; Lysalgo; Tanston; Acide mefenamique; Mefenaminsaeure; CN-35355; N-2,3-Xylylanthranilic acid

Frequently Asked Questions

What are the CAS number and molecular formula of mefenamic acid?

CAS 61-68-7; molecular formula C15H15NO2; molecular weight — g/mol.

What other names is mefenamic acid known by?

mefenamic acid, 61-68-7, Ponstel, 2-[(2,3-dimethylphenyl)amino]benzoic acid, Mephenamic acid, 2-((2,3-Dimethylphenyl)amino)benzoic acid.

Is mefenamic acid classified as hazardous?

0.8% of GHS notifications report no hazard classification (1 of 126).

What are the key physical properties of mefenamic acid?

Melting Point: 230-231 °C; Melting Point: 230 - 231 °C; Solubility: 20; Solubility: 1.37e-02 g/L.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.