芬苯达唑

Description

fenbendazole · CAS 43210-67-9 · C15H13N3O2S. UNII 621BVT9M36. Melting Point: 233 °C.

Identification

CAS Registry Number	43210-67-9
PubChem CID	3334
Molecular formula	C15H13N3O2S
IUPAC name	methyl N-(6-phenylsulfanyl-1H-benzimidazol-2-yl)carbamate
UNII (FDA)	621BVT9M36

Computed Descriptors

Molecular Weight	299.3
XLogP3	3.6
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	4
Exact Mass	299.07284784
Monoisotopic Mass	299.07284784
Topological Polar Surface Area	92.3
Heavy Atom Count	21
Formal Charge	0

Physical & Chemical Properties

Melting Point	233 °C

Physical description & handling notes

• Solid
• 0.9 [ug/mL] (The mean of the results at pH 7.4)
• 174.9 Ų [M-H]- [CCS Type: DT; Buffer gas: N2; Ionization: ESI-; Dataset: TOXCAST; Source Identifier: DTXSID0040672]
• 174.6 Ų [M+H]+ [CCS Type: DT; Buffer gas: N2; Ionization: ESI+; Dataset: TOXCAST; Source Identifier: DTXSID0040672]
• 175.0 Ų [M+H]+ [CCS Type: DT; Buffer gas: N2; Ionization: APCI+; Dataset: TOXCAST; Source Identifier: DTXSID0040672]
• 170.8 Ų [M+H]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]

Regulatory Status

Regulatory & Food Contact	ANTHELMINTHIC_AGENT: Veterinary Drug AXILUR® 0-7 µg/kg bw (group ADI) TRS 888-JECFA 50/13 FAS 41-JECFA 50/23 HOE 881
GHS notification summary	1.3% (2 / 157)

GHS Hazard Classification

GHS notification summary	1.3% (2 / 157)
Reported hazard statements	H361 (66.2%), H373 (31.8%), H400 (73.9%), H410 (68.8%), H412 (23.6%)

Documented Uses

• Fenbendazole is a benzimidazole anthelmintic agent commonly used to treat animal parasitic infections. In humans, other benzimidazoles, such as mebendazole and albendazole, are used as antiparasitic agents. Fenbendazole is not currently approved by the FDA or EMA and its pharmacokinetics and safety in humans are not well-documented.
• Animal Drugs -> FDA Approved Animal Drug Products (Green Book) -> Active Ingredients
• Veterinary Drug -> ANTHELMINTHIC_AGENT -> JECFA Functional Classes
• Pharmaceuticals -> Animal Drugs -> Approved in Taiwan
• Fenbendazole is a veterinary anthelmintic agent used predominantly to treat parasitic worm infestations in domestic cats and dogs. Fenbendazole is not approved for use in humans but has been claimed to have antineoplastic activity, and because the veterinary drug is available over the counter, it has been re-purposed and used off label to treat cancer. Fenbendazole therapy is commonly associated with mild and transient serum enzyme elevations and can also lead to clinically apparent acute liver injury.
• Substances used in the treatment or control of nematode infestations. They are used also in veterinary practice.

Synonyms

fenbendazole; 43210-67-9; Panacur; Fenbendazol; Phenbendasol; Fenbendazolum; Hoe 881v; Methyl 5-(phenylthio)-2-benzimidazolecarbamate; Safe-quard; Safe-Guard; HOE-881v; Panacur aquasol; DTXSID0040672; 2-(Methoxycarbonylamino)-5-(phenylthio)benzimidazole; NSC-757824; Fenbendazole for veterinary use

Frequently Asked Questions

What are the CAS number and molecular formula of fenbendazole?

CAS 43210-67-9; molecular formula C15H13N3O2S; molecular weight — g/mol.

What other names is fenbendazole known by?

fenbendazole, 43210-67-9, Panacur, Fenbendazol, Phenbendasol, Fenbendazolum.

What is the regulatory status of fenbendazole?

Documented regulatory listings: ANTHELMINTHIC_AGENT: Veterinary Drug; AXILUR®; 0-7 µg/kg bw (group ADI).

Is fenbendazole classified as hazardous?

1.3% of GHS notifications report no hazard classification (2 of 157).

What are the key physical properties of fenbendazole?

Melting Point: 233 °C.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.