卡马西平

CAS 298-46-4C15H12N2OMW 236.27

卡马西平（CAS 298-46-4）：分子式 C15H12N2O、分子量 236.27。

产品概览

CAS号	298-46-4
分子式	C15H12N2O
分子量	236.27
熔点	189-192
沸点	399.6±45.0
LogP	2.77
应用领域	Uses: Analgesic、antiepileptic drug、In the treatment of pain associated with trigeminal neuralgia、THERAP CAT: Anticonvulsant、MEDICATION、Use (kg) in Switzerland (2009): >2500、Use (kg、approx.) in Germany (2009): >50000、exact) in Germany (2009): 64270、Use (kg) in USA (2002): 38400、Use (kg) in France (2004): 33514、Consumption (g per capita) in Switzerland (2009): 0.32、Consumption (g per capita、approx.) in Germany (2009): 0.61、exact) in Germany (2009): 0.78、Consumption (g per capita) in the USA (2002): 0.14、Consumption (g per capita) in France (2004): 0.55、Excretion rate: 0.26、Calculated removal (%): 24.5、For the treatment of epilepsy and pain associated with true trigeminal neuralgia.、Use Classification: Pharmaceuticals -> Nervous System -> Antiepileptics -> Carboxamide derivatives、Pharmaceuticals、Methods of Manufacturing: THERMAL DEAMMONIATION OF 2-(O-AMINOSTYRYL)ANILINE HYDROCHLORIDE TO FORM 5H-DIBENZ(B、F)AZEPINE FOLLOWED BY CONDENSATION WITH CARBAMOYL CHLORIDE IN THE PRESENCE OF SODAMIDE、Prepn: W. Schindler、US 2948718 (1960 to Geigy).、Iminostilbene + phosgene + ammonia (phosgenation、dehydrochlorination)、5H-dibenz(b、f)azepine is first reacted with phosgene and then with ammonia.、Formulations、Preparations: Oral: Capsules、extended-release: 200 mg Carbatrol (with povidone)、(Shire US)、300 mg Carbatrol (with povidone)、(Shire US). Suspension: 100 mg、5 mL Carbamazepine Suspension、(Actavis)、Carbamazepine Suspension、(Morton Grove)、(Taro)、Tegretol ( with propylene glycol)、(Novartis). Tablets: 200 mg Epitol (scored)、(Teva)、Tegretol (scored)、(Novartis). Tablets、chewable: 100 mg Tegretol (scored)、extended-release: 100 mg Tegretol-XR (with mannitol)、(Novartis)、200 mg Tegretol-XR (with mannitol)、400 mg Tegretol-XR (with mannitol)、(Novartis).、Consumption Patterns: Amount used per year in the UK: 40.348.75 kg、(1995) estimated prescription amount in Germany was calculated to be 80 tons、U.S. Production: (1977) PROBABLY GREATER THAN 4.54X10+5 GRAMS、(1979) PROBABLY GREATER THAN 4.54X10+5 GRAMS

应用领域

登记用途：Uses: Analgesic、antiepileptic drug、In the treatment of pain associated with trigeminal neuralgia、THERAP CAT: Anticonvulsant、MEDICATION、Use (kg) in Switzerland (2009): >2500、Use (kg、approx.) in Germany (2009): >50000、exact) in Germany (2009): 64270、Use (kg) in USA (2002): 38400、Use (kg) in France (2004): 33514、Consumption (g per capita) in Switzerland (2009): 0.32、Consumption (g per capita、approx.) in Germany (2009): 0.61、exact) in Germany (2009): 0.78、Consumption (g per capita) in the USA (2002): 0.14、Consumption (g per capita) in France (2004): 0.55、Excretion rate: 0.26、Calculated removal (%): 24.5、For the treatment of epilepsy and pain associated with true trigeminal neuralgia.、Use Classification: Pharmaceuticals -> Nervous System -> Antiepileptics -> Carboxamide derivatives、Pharmaceuticals、Methods of Manufacturing: THERMAL DEAMMONIATION OF 2-(O-AMINOSTYRYL)ANILINE HYDROCHLORIDE TO FORM 5H-DIBENZ(B、F)AZEPINE FOLLOWED BY CONDENSATION WITH CARBAMOYL CHLORIDE IN THE PRESENCE OF SODAMIDE、Prepn: W. Schindler、US 2948718 (1960 to Geigy).、Iminostilbene + phosgene + ammonia (phosgenation、dehydrochlorination)、5H-dibenz(b、f)azepine is first reacted with phosgene and then with ammonia.、Formulations、Preparations: Oral: Capsules、extended-release: 200 mg Carbatrol (with povidone)、(Shire US)、300 mg Carbatrol (with povidone)、(Shire US). Suspension: 100 mg、5 mL Carbamazepine Suspension、(Actavis)、Carbamazepine Suspension、(Morton Grove)、(Taro)、Tegretol ( with propylene glycol)、(Novartis). Tablets: 200 mg Epitol (scored)、(Teva)、Tegretol (scored)、(Novartis). Tablets、chewable: 100 mg Tegretol (scored)、extended-release: 100 mg Tegretol-XR (with mannitol)、(Novartis)、200 mg Tegretol-XR (with mannitol)、400 mg Tegretol-XR (with mannitol)、(Novartis).、Consumption Patterns: Amount used per year in the UK: 40.348.75 kg、(1995) estimated prescription amount in Germany was calculated to be 80 tons、U.S. Production: (1977) PROBABLY GREATER THAN 4.54X10+5 GRAMS、(1979) PROBABLY GREATER THAN 4.54X10+5 GRAMS。

技术档案

这个产品是什么

卡马西平是一种化工化合物，登记 CAS 号为 298-46-4，分子式 C15H12N2O（分子量 236.27）。

识别信息

登记 CAS 号：298-46-4

其分子式 C15H12N2O 由 15 个碳、12 个氢、2 个氮、1 个氧组成。

别名/同义词：卡马西平 · CARBAMAZEPINE

常见问题

卡马西平的 CAS 号是多少？

卡马西平的 CAS 登记号为 298-46-4。

卡马西平的分子式与分子量是多少？

分子式 C15H12N2O，分子量 236.27。

卡马西平还有哪些别名？

别名/同义词：卡马西平、CARBAMAZEPINE。

卡马西平的登记用途是什么？

PubChem 公开数据

卡马西平（CAS 298-46-4）的独立参考数据，整理自公开化学数据库。

各数据库的登记标识

CAS Registry Number	298-46-4
PubChem CID	2554
Molecular formula	C15H12N2O
IUPAC name	benzo[b][1]benzazepine-11-carboxamide
UNII (FDA)	33CM23913M

计算分子描述符

Molecular Weight	236.27
XLogP3	2.5
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	1
Rotatable Bond Count	0
Exact Mass	236.094963011
Monoisotopic Mass	236.094963011
Topological Polar Surface Area	46.3
Heavy Atom Count	18

在册的理化数值

Boiling Point	399.6±45.0
Melting Point	189-192
Melting Point	190.2 °C
Solubility	1.52e-01 g/L
LogP	2.77
LogP	log Kow = 2.45
LogP	2.3
LogP	2.34
Ionization Efficiency	2.4
Ionization Efficiency	2.7

在册的记载用途

同义词与商品名

carbamazepine; 298-46-4; Tegretol; 5H-Dibenz[b,f]azepine-5-carboxamide; Finlepsin; Tegretal; Carbamazepen; Carbazepine; Biston; Telesmin; Equetro; Timonil; Carbamezepine; Karbamazepin; Carbatrol; Neurotol

已收录的法规名录

GHS notification summary	0.5% (1 / 210)

GHS 危害分类

GHS notification summary	0.5% (1 / 210)
Reported hazard statements	H302 (96.2%), H317 (94.3%), H334 (87.6%)

This chemical does not meet GHS hazard criteria for 0.5% (1 of 210) of reports.

H302 (96.2%): Harmful if swallowed [Warning Acute toxicity, oral]

公开数据库对它的描述

CARBAMAZEPINE · CAS 298-46-4 · C15H12N2O. UNII 33CM23913M. Boiling Point: 399.6±45.0; Melting Point: 189-192; Melting Point: 190.2 °C.

物理形态与操作说明

数据来源：PubChem / Wikidata；与随货 COA 不一致时以 COA 为准。