CARBAMAZEPINE (CAS 298-46-4) — formula C15H12N2O, molecular weight 236.27.
| CAS Number | 298-46-4 |
|---|---|
| Molecular Formula | C15H12N2O |
| Molecular Weight | 236.27 |
| Melting Point | 189-192 |
| Boiling Point | 399.6±45.0 |
| LogP | 2.77 |
| Applications | Uses: Analgesic, antiepileptic drug, In the treatment of pain associated with trigeminal neuralgia, THERAP CAT: Anticonvulsant, MEDICATION, Use (kg) in Switzerland (2009): >2500, Use (kg, approx.) in Germany (2009): >50000, exact) in Germany (2009): 64270, Use (kg) in USA (2002): 38400, Use (kg) in France (2004): 33514, Consumption (g per capita) in Switzerland (2009): 0.32, Consumption (g per capita, approx.) in Germany (2009): 0.61, exact) in Germany (2009): 0.78, Consumption (g per capita) in the USA (2002): 0.14, Consumption (g per capita) in France (2004): 0.55, Excretion rate: 0.26, Calculated removal (%): 24.5, For the treatment of epilepsy and pain associated with true trigeminal neuralgia., Use Classification: Pharmaceuticals -> Nervous System -> Antiepileptics -> Carboxamide derivatives, Pharmaceuticals, Methods of Manufacturing: THERMAL DEAMMONIATION OF 2-(O-AMINOSTYRYL)ANILINE HYDROCHLORIDE TO FORM 5H-DIBENZ(B, F)AZEPINE FOLLOWED BY CONDENSATION WITH CARBAMOYL CHLORIDE IN THE PRESENCE OF SODAMIDE, Prepn: W. Schindler, US 2948718 (1960 to Geigy)., Iminostilbene + phosgene + ammonia (phosgenation, dehydrochlorination), 5H-dibenz(b, f)azepine is first reacted with phosgene and then with ammonia., Formulations, Preparations: Oral: Capsules, extended-release: 200 mg Carbatrol (with povidone), (Shire US), 300 mg Carbatrol (with povidone), (Shire US). Suspension: 100 mg, 5 mL Carbamazepine Suspension, (Actavis), Carbamazepine Suspension, (Morton Grove), (Taro), Tegretol ( with propylene glycol), (Novartis). Tablets: 200 mg Epitol (scored), (Teva), Tegretol (scored), (Novartis). Tablets, chewable: 100 mg Tegretol (scored), extended-release: 100 mg Tegretol-XR (with mannitol), (Novartis), 200 mg Tegretol-XR (with mannitol), 400 mg Tegretol-XR (with mannitol), (Novartis)., Consumption Patterns: Amount used per year in the UK: 40.348.75 kg, (1995) estimated prescription amount in Germany was calculated to be 80 tons, U.S. Production: (1977) PROBABLY GREATER THAN 4.54X10+5 GRAMS, (1979) PROBABLY GREATER THAN 4.54X10+5 GRAMS |
Documented applications: Uses: Analgesic, antiepileptic drug, In the treatment of pain associated with trigeminal neuralgia, THERAP CAT: Anticonvulsant, MEDICATION, Use (kg) in Switzerland (2009): >2500, Use (kg, approx.) in Germany (2009): >50000, exact) in Germany (2009): 64270, Use (kg) in USA (2002): 38400, Use (kg) in France (2004): 33514, Consumption (g per capita) in Switzerland (2009): 0.32, Consumption (g per capita, approx.) in Germany (2009): 0.61, exact) in Germany (2009): 0.78, Consumption (g per capita) in the USA (2002): 0.14, Consumption (g per capita) in France (2004): 0.55, Excretion rate: 0.26, Calculated removal (%): 24.5, For the treatment of epilepsy and pain associated with true trigeminal neuralgia., Use Classification: Pharmaceuticals -> Nervous System -> Antiepileptics -> Carboxamide derivatives, Pharmaceuticals, Methods of Manufacturing: THERMAL DEAMMONIATION OF 2-(O-AMINOSTYRYL)ANILINE HYDROCHLORIDE TO FORM 5H-DIBENZ(B, F)AZEPINE FOLLOWED BY CONDENSATION WITH CARBAMOYL CHLORIDE IN THE PRESENCE OF SODAMIDE, Prepn: W. Schindler, US 2948718 (1960 to Geigy)., Iminostilbene + phosgene + ammonia (phosgenation, dehydrochlorination), 5H-dibenz(b, f)azepine is first reacted with phosgene and then with ammonia., Formulations, Preparations: Oral: Capsules, extended-release: 200 mg Carbatrol (with povidone), (Shire US), 300 mg Carbatrol (with povidone), (Shire US). Suspension: 100 mg, 5 mL Carbamazepine Suspension, (Actavis), Carbamazepine Suspension, (Morton Grove), (Taro), Tegretol ( with propylene glycol), (Novartis). Tablets: 200 mg Epitol (scored), (Teva), Tegretol (scored), (Novartis). Tablets, chewable: 100 mg Tegretol (scored), extended-release: 100 mg Tegretol-XR (with mannitol), (Novartis), 200 mg Tegretol-XR (with mannitol), 400 mg Tegretol-XR (with mannitol), (Novartis)., Consumption Patterns: Amount used per year in the UK: 40.348.75 kg, (1995) estimated prescription amount in Germany was calculated to be 80 tons, U.S. Production: (1977) PROBABLY GREATER THAN 4.54X10+5 GRAMS, (1979) PROBABLY GREATER THAN 4.54X10+5 GRAMS.
CARBAMAZEPINE is a chemical compound with CAS registry number 298-46-4 and molecular formula C15H12N2O (molecular weight 236.27).
CAS number: 298-46-4
Its molecular formula C15H12N2O comprises 15 C, 12 H, 2 N, 1 O atoms.
Also known as: CARBAMAZEPINE · 卡马西平
The CAS registry number of CARBAMAZEPINE is 298-46-4.
Molecular formula C15H12N2O, molecular weight 236.27.
It is also registered under: CARBAMAZEPINE, 卡马西平.
Recorded applications: Uses: Analgesic, antiepileptic drug, In the treatment of pain associated with trigeminal neuralgia, THERAP CAT: Anticonvulsant, MEDICATION, Use (kg) in Switzerland (2009): >2500, Use (kg, approx.) in Germany (2009): >50000, exact) in Germany (2009): 64270, Use (kg) in USA (2002): 38400, Use (kg) in France (2004): 33514, Consumption (g per capita) in Switzerland (2009): 0.32, Consumption (g per capita, approx.) in Germany (2009): 0.61, exact) in Germany (2009): 0.78, Consumption (g per capita) in the USA (2002): 0.14, Consumption (g per capita) in France (2004): 0.55, Excretion rate: 0.26, Calculated removal (%): 24.5, For the treatment of epilepsy and pain associated with true trigeminal neuralgia., Use Classification: Pharmaceuticals -> Nervous System -> Antiepileptics -> Carboxamide derivatives, Pharmaceuticals, Methods of Manufacturing: THERMAL DEAMMONIATION OF 2-(O-AMINOSTYRYL)ANILINE HYDROCHLORIDE TO FORM 5H-DIBENZ(B, F)AZEPINE FOLLOWED BY CONDENSATION WITH CARBAMOYL CHLORIDE IN THE PRESENCE OF SODAMIDE, Prepn: W. Schindler, US 2948718 (1960 to Geigy)., Iminostilbene + phosgene + ammonia (phosgenation, dehydrochlorination), 5H-dibenz(b, f)azepine is first reacted with phosgene and then with ammonia., Formulations, Preparations: Oral: Capsules, extended-release: 200 mg Carbatrol (with povidone), (Shire US), 300 mg Carbatrol (with povidone), (Shire US). Suspension: 100 mg, 5 mL Carbamazepine Suspension, (Actavis), Carbamazepine Suspension, (Morton Grove), (Taro), Tegretol ( with propylene glycol), (Novartis). Tablets: 200 mg Epitol (scored), (Teva), Tegretol (scored), (Novartis). Tablets, chewable: 100 mg Tegretol (scored), extended-release: 100 mg Tegretol-XR (with mannitol), (Novartis), 200 mg Tegretol-XR (with mannitol), 400 mg Tegretol-XR (with mannitol), (Novartis)., Consumption Patterns: Amount used per year in the UK: 40.348.75 kg, (1995) estimated prescription amount in Germany was calculated to be 80 tons, U.S. Production: (1977) PROBABLY GREATER THAN 4.54X10+5 GRAMS, (1979) PROBABLY GREATER THAN 4.54X10+5 GRAMS.
Independent reference data for CARBAMAZEPINE (CAS 298-46-4), compiled from public chemistry databases.
| CAS Registry Number | 298-46-4 |
|---|---|
| PubChem CID | 2554 |
| Molecular formula | C15H12N2O |
| IUPAC name | benzo[b][1]benzazepine-11-carboxamide |
| UNII (FDA) | 33CM23913M |
| Molecular Weight | 236.27 |
|---|---|
| XLogP3 | 2.5 |
| Hydrogen Bond Donor Count | 1 |
| Hydrogen Bond Acceptor Count | 1 |
| Rotatable Bond Count | 0 |
| Exact Mass | 236.094963011 |
| Monoisotopic Mass | 236.094963011 |
| Topological Polar Surface Area | 46.3 |
| Heavy Atom Count | 18 |
| Boiling Point | 399.6±45.0 |
|---|---|
| Melting Point | 189-192 |
| Melting Point | 190.2 °C |
| Solubility | 1.52e-01 g/L |
| LogP | 2.77 |
| LogP | log Kow = 2.45 |
| LogP | 2.3 |
| LogP | 2.34 |
| Ionization Efficiency | 2.4 |
| Ionization Efficiency | 2.7 |
carbamazepine; 298-46-4; Tegretol; 5H-Dibenz[b,f]azepine-5-carboxamide; Finlepsin; Tegretal; Carbamazepen; Carbazepine; Biston; Telesmin; Equetro; Timonil; Carbamezepine; Karbamazepin; Carbatrol; Neurotol
| GHS notification summary | 0.5% (1 / 210) |
|---|
| GHS notification summary | 0.5% (1 / 210) |
|---|---|
| Reported hazard statements | H302 (96.2%), H317 (94.3%), H334 (87.6%) |
This chemical does not meet GHS hazard criteria for 0.5% (1 of 210) of reports.
H302 (96.2%): Harmful if swallowed [Warning Acute toxicity, oral]
CARBAMAZEPINE · CAS 298-46-4 · C15H12N2O. UNII 33CM23913M. Boiling Point: 399.6±45.0; Melting Point: 189-192; Melting Point: 190.2 °C.
Source: PubChem / Wikidata; the batch COA governs where values differ.
Supplier: Jinan Shenghe Chemical Co., Ltd.
中文页面: 卡马西平