克立硼罗

Description

5-(4-cyanophenoxy)-2,3-dihydro-1-hydroxy-2,1-benzoxaborole · CAS 906673-24-3 · C14H10BNO3. UNII Q2R47HGR7P.

Identification

CAS Registry Number	906673-24-3
PubChem CID	44591583
Molecular formula	C14H10BNO3
IUPAC name	4-[(1-hydroxy-3H-2,1-benzoxaborol-5-yl)oxy]benzonitrile
UNII (FDA)	Q2R47HGR7P

Computed Descriptors

Molecular Weight	251.05
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	2
Exact Mass	251.0753733
Monoisotopic Mass	251.0753733
Topological Polar Surface Area	62.5
Heavy Atom Count	19
Formal Charge	0
Complexity	361

Physical description & handling notes

• Insoluble

Regulatory Status

GHS notification summary	6.5% (2 / 31)

GHS Hazard Classification

GHS notification summary	6.5% (2 / 31)
Reported hazard statements	H302 (93.5%), H315 (90.3%), H319 (93.5%)

Documented Uses

• Intended for the topical treatment of mild to moderate atopic dermatitis in patients 2 years of age and older.
• Breast Feeding; Lactation; Milk, Human; Enzyme Inhibitors; Phosphodiesterase Inhibitors
• Established Pharmacologic Class [EPC] - Phosphodiesterase 4 Inhibitor
• Mechanisms of Action [MoA] - Phosphodiesterase 4 Inhibitors
• Crisaborole is a Phosphodiesterase 4 Inhibitor. The mechanism of action of crisaborole is as a Phosphodiesterase 4 Inhibitor.
• Phosphodiesterase 4 Inhibitor [EPC]; Phosphodiesterase 4 Inhibitors [MoA]

Synonyms

Crisaborole; 906673-24-3; AN-2728; AN2728; Eucrisa; AN 2728; Staquis; crisaborol; Crisaborole topical ointment 2%; 4-[(1-hydroxy-3H-2,1-benzoxaborol-5-yl)oxy]benzonitrile; Q2R47HGR7P; 4-[(1-hydroxy-1,3-dihydro-2,1-benzoxaborol-5-yl)oxy]benzonitrile; CHEBI:134677; DTXSID10238231; 4-((1-Hydroxy-1,3-dihydrobenzo(c)(1,2)oxaborol-6-yl)oxy)benzonitrile; Benzonitrile, 4-((1,3-dihydro-1-hydroxy-2,1-benzoxaborol-5-yl)oxy)-

Frequently Asked Questions

What are the CAS number and molecular formula of 5-(4-cyanophenoxy)-2,3-dihydro-1-hydroxy-2,1-benzoxaborole?

CAS 906673-24-3; molecular formula C14H10BNO3; molecular weight — g/mol.

What other names is 5-(4-cyanophenoxy)-2,3-dihydro-1-hydroxy-2,1-benzoxaborole known by?

Crisaborole, 906673-24-3, AN-2728, AN2728, Eucrisa, AN 2728.

Is 5-(4-cyanophenoxy)-2,3-dihydro-1-hydroxy-2,1-benzoxaborole classified as hazardous?

6.5% of GHS notifications report no hazard classification (2 of 31).

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.