Tris Base (CAS 77-86-1) — formula C4H11NO3, molecular weight 121.14; category pharmaceutical intermediates and APIs.
| CAS Number | 77-86-1 |
|---|---|
| Molecular Formula | C4H11NO3 |
| Molecular Weight | 121.14 |
| Melting Point | 171-172 °C |
| Boiling Point | 219-220 °C at 10 mm Hg |
| LogP | -2.9 |
| Packaging | 25/50kg woven bags, 20/25/50kg fibre drums, 200kg plastic drums, 1000kg IBC (subject to order confirmation) |
| Category | Pharmaceutical Raw Materials |
Tris Base is a pharmaceutical intermediate or API compound with CAS registry number 77-86-1 and molecular formula C4H11NO3 (molecular weight 121.14), belonging to the pharmaceutical intermediates and APIs segment of chemical raw materials.
CAS number: 77-86-1
Its molecular formula C4H11NO3 comprises 4 C, 11 H, 1 N, 3 O atoms.
Also known as: Tris Base · 三羟甲基氨基甲烷 · Tris(hydroxymethyl)aminomethane
Category: pharmaceutical intermediates and APIs
The CAS registry number of Tris Base is 77-86-1.
Molecular formula C4H11NO3, molecular weight 121.14.
It is also registered under: Tris Base, 三羟甲基氨基甲烷, Tris(hydroxymethyl)aminomethane.
Category: Pharmaceutical Raw Materials.
Packaging is agreed per order, from lab-scale packs to bulk, and confirmed with each order rather than fixed on the page. A Certificate of Analysis (COA) ships with every batch and MSDS is available; where the end use carries a regulatory limit (food contact, pharmaceutical or cosmetic), state the standard at enquiry and the grade is set against it.
Independent reference data for Tris Base (CAS 77-86-1), compiled from public chemistry databases.
| CAS Number | 77-86-1 |
|---|---|
| PubChem CID | 6503 |
| Molecular Formula | C4H11NO3 |
| IUPAC Name | 2-amino-2-(hydroxymethyl)propane-1,3-diol |
| UNII (FDA) | 023C2WHX2V |
| Molecular Weight | 121.14 |
|---|---|
| XLogP3 | -2.9 |
| Hydrogen Bond Donor Count | 4 |
| Hydrogen Bond Acceptor Count | 4 |
| Rotatable Bond Count | 3 |
| Exact Mass | 121.07389321 |
| Monoisotopic Mass | 121.07389321 |
| Topological Polar Surface Area | 86.7 |
| Heavy Atom Count | 8 |
| Boiling Point | 219-220 °C at 10 mm Hg |
|---|---|
| Melting Point | 171-172 °C |
| Solubility | In water, 5.50X10+5 mg/L at 25 °C |
| Vapor Pressure | 0.000022 [mmHg] |
| Ionization Efficiency | 2.41 |
| Ionization Efficiency | 2.7 |
| Ionization Efficiency | MeCN (80%) |
| Ionization Efficiency | DOI:10.1007/s13361-016-1563-2 |
| Dissociation Constants | 8.08 |
| Dissociation Constants | pKa = 8.07 |
| Regulatory & food contact | CIR / INCI: Cosmetic ingredients (Tromethamine) -> CIR (Cosmetic Ingredient Review) |
|---|---|
| GHS notifications | 19.7% (235 / 1192) |
| GHS notifications | 19.7% (235 / 1192) |
|---|---|
| Notified hazard statements | H315 (80.2%), H319 (80.3%), H335 (70.8%) |
Source: PubChem / Wikidata; the batch COA governs where values differ.
Supplier: Jinan Shenghe Chemical Co., Ltd.
中文页面: 三羟甲基氨基甲烷