Acetaminophen

Acetaminophen (CAS 103-90-2) — formula C8H9NO2, molecular weight 151.16.

Product Overview

Applications

Documented applications: Uses: Registered for use in the US for control of brown tree snakes, [NPIRS] Used to make azo dyes, photographic chemicals, and pharmaceuticals, as a stabilizer for hydrogen peroxide, and as a therapeutic analgesic and antipyretic, [HSDB], Manufacture of azo dyes, photographic chemicals., Stabilizer for hydrogen peroxide, An analgesic used as an aspirin substitute, Analgesics, Non-Narcotic, Antipyretics, For more Uses (Complete) data for ACETAMINOPHEN (6 total), please visit the HSDB record page., Use (kg) in Switzerland (2009): >100000, Use (kg, approx.) in Germany (2009): >500000, exact) in Germany (2009): 564712, Use (kg) in USA (2002): 5790000, Use (kg) in France (2004): 3303077, Consumption (g per capita) in Switzerland (2009): 13, Consumption (g per capita, approx.) in Germany (2009): 6.1, exact) in Germany (2009): 6.9, Consumption (g per capita) in the USA (2002): 21, Consumption (g per capita) in France (2004): 55, Excretion rate: 0.037, Calculated removal (%): 75.1, An over-the-counter analgesic (pain reliever) and antipyretic (fever reducer). It is commonly used for the relief of fever, headaches, and other minor aches and pains, and is a major ingredient in numerous cold and flu remedies., Use Classification: Cosmetics -> Stabilizing, Pharmaceuticals -> Animal Drugs -> Approved in Taiwan, Methods of Manufacturing: p-Nitrophenol is reduced and the resulting p-aminophenol is acetylated by means of heating with a mixture of acetic anhydride and glacial acetic acid. The crude product may be purified by recrystallization from an ethanol-water mixture., Production is by the acetylation of 4-aminophenol. This can be achieved with acetic acid and acetic anhydride at 80 °C, with acetic anhydride in pyridine at 100 °C, with acetyl chloride and pyridine in toluene at 60 °C, or by the action of ketene in alcoholic suspension. 4-Hydroxyacetanilide also may be synthesized directly from 4-nitrophenol. The available reduction-acetylation systems include tin with acetic acid, hydrogenation over Pd-C in acetic anhydride, and hydrogenation over platinum in acetic acid., Preparation: ... Wilbert, De Angelis, United States of America patent 2998450 (1961 to Warner-Lambert)., Formulations, Preparations: Table: Acetaminophen Preparations [Table#4343], Ofirmev: (acetaminophen) injection: 1000 mg, 100mL (10 mg, mL), Common combination products containing acetaminophen include the following: Darvocet, Excedrin ES, Lorcet, Norco, NyQuil, Percocet, Unisom dual relief formula, Sominex 2, tylenol with Codeine, Tylenol PM, Tylox, Vicks formula 44-D, and Vicodin., Proprietary Preparation: Crocin (India), Consumption Patterns: PRINCIPALLY USED AS A MEDICINAL (1976)., Acetaminophen. Analgesic, 75%, exports, 25%., CHEMICAL PROFILE: Acetaminophen. Demand: 1987: 30 million lb, 1988: 30.5 million lb, 1992, projected, : 31.5 million lb (Includes exports, but not imports, which totaled about 5 million lb last year.), U.S. Production: (1975) 4.5X10+9 GRAMS (INCL PHENACETIN), (1976) GREATER THAN 2.27X10+6 GRAMS, Acetaminophen was one of the most used pharmaceuticals in England during 2002, at an amount used per year of 390, 954.26 kg and has been detected in the environment., Production volumes for non-confidential chemicals reported under the Inventory Update Rule.[Table#4345], For more U.S. Production (Complete) data for ACETAMINOPHEN (6 total), U.S. Imports: (1972) 9.1X10+7 GRAMS (PRINCPL CUSTMS DISTS), (1975) 3.46X10+8 GRAMS (PRINCPL CUSTMS DISTS), General Manufacturing Information: Acetamide, N-(4-hydroxyphenyl)-: ACTIVE.

Technical Profile

What this product is

Acetaminophen is a chemical compound with CAS registry number 103-90-2 and molecular formula C8H9NO2 (molecular weight 151.16).

Identification

CAS number: 103-90-2

Its molecular formula C8H9NO2 comprises 8 C, 9 H, 1 N, 2 O atoms.

Also known as: Acetaminophen · 对乙酰氨基酚

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