对乙酰氨基酚(CAS 103-90-2):分子式 C8H9NO2、分子量 151.16。
| CAS号 | 103-90-2 |
|---|---|
| 分子式 | C8H9NO2 |
| 分子量 | 151.16 |
| 熔点 | 336 to 342 °F (NTP, 1992) |
| 沸点 | >500 |
| LogP | 0.5 |
| 应用领域 | Uses: Registered for use in the US for control of brown tree snakes、[NPIRS] Used to make azo dyes、photographic chemicals、and pharmaceuticals、as a stabilizer for hydrogen peroxide、and as a therapeutic analgesic and antipyretic、[HSDB]、Manufacture of azo dyes、photographic chemicals.、Stabilizer for hydrogen peroxide、An analgesic used as an aspirin substitute、Analgesics、Non-Narcotic、Antipyretics、For more Uses (Complete) data for ACETAMINOPHEN (6 total)、please visit the HSDB record page.、Use (kg) in Switzerland (2009): >100000、Use (kg、approx.) in Germany (2009): >500000、exact) in Germany (2009): 564712、Use (kg) in USA (2002): 5790000、Use (kg) in France (2004): 3303077、Consumption (g per capita) in Switzerland (2009): 13、Consumption (g per capita、approx.) in Germany (2009): 6.1、exact) in Germany (2009): 6.9、Consumption (g per capita) in the USA (2002): 21、Consumption (g per capita) in France (2004): 55、Excretion rate: 0.037、Calculated removal (%): 75.1、An over-the-counter analgesic (pain reliever) and antipyretic (fever reducer). It is commonly used for the relief of fever、headaches、and other minor aches and pains、and is a major ingredient in numerous cold and flu remedies.、Use Classification: Cosmetics -> Stabilizing、Pharmaceuticals -> Animal Drugs -> Approved in Taiwan、Methods of Manufacturing: p-Nitrophenol is reduced and the resulting p-aminophenol is acetylated by means of heating with a mixture of acetic anhydride and glacial acetic acid. The crude product may be purified by recrystallization from an ethanol-water mixture.、Production is by the acetylation of 4-aminophenol. This can be achieved with acetic acid and acetic anhydride at 80 °C、with acetic anhydride in pyridine at 100 °C、with acetyl chloride and pyridine in toluene at 60 °C、or by the action of ketene in alcoholic suspension. 4-Hydroxyacetanilide also may be synthesized directly from 4-nitrophenol. The available reduction-acetylation systems include tin with acetic acid、hydrogenation over Pd-C in acetic anhydride、and hydrogenation over platinum in acetic acid.、Preparation: ... Wilbert、De Angelis、United States of America patent 2998450 (1961 to Warner-Lambert).、Formulations、Preparations: Table: Acetaminophen Preparations [Table#4343]、Ofirmev: (acetaminophen) injection: 1000 mg、100mL (10 mg、mL)、Common combination products containing acetaminophen include the following: Darvocet、Excedrin ES、Lorcet、Norco、NyQuil、Percocet、Unisom dual relief formula、Sominex 2、tylenol with Codeine、Tylenol PM、Tylox、Vicks formula 44-D、and Vicodin.、Proprietary Preparation: Crocin (India)、Consumption Patterns: PRINCIPALLY USED AS A MEDICINAL (1976).、Acetaminophen. Analgesic、75%、exports、25%.、CHEMICAL PROFILE: Acetaminophen. Demand: 1987: 30 million lb、1988: 30.5 million lb、1992、projected、: 31.5 million lb (Includes exports、but not imports、which totaled about 5 million lb last year.)、U.S. Production: (1975) 4.5X10+9 GRAMS (INCL PHENACETIN)、(1976) GREATER THAN 2.27X10+6 GRAMS、Acetaminophen was one of the most used pharmaceuticals in England during 2002、at an amount used per year of 390、954.26 kg and has been detected in the environment.、Production volumes for non-confidential chemicals reported under the Inventory Update Rule.[Table#4345]、For more U.S. Production (Complete) data for ACETAMINOPHEN (6 total)、U.S. Imports: (1972) 9.1X10+7 GRAMS (PRINCPL CUSTMS DISTS)、(1975) 3.46X10+8 GRAMS (PRINCPL CUSTMS DISTS)、General Manufacturing Information: Acetamide、N-(4-hydroxyphenyl)-: ACTIVE |
登记用途:Uses: Registered for use in the US for control of brown tree snakes、[NPIRS] Used to make azo dyes、photographic chemicals、and pharmaceuticals、as a stabilizer for hydrogen peroxide、and as a therapeutic analgesic and antipyretic、[HSDB]、Manufacture of azo dyes、photographic chemicals.、Stabilizer for hydrogen peroxide、An analgesic used as an aspirin substitute、Analgesics、Non-Narcotic、Antipyretics、For more Uses (Complete) data for ACETAMINOPHEN (6 total)、please visit the HSDB record page.、Use (kg) in Switzerland (2009): >100000、Use (kg、approx.) in Germany (2009): >500000、exact) in Germany (2009): 564712、Use (kg) in USA (2002): 5790000、Use (kg) in France (2004): 3303077、Consumption (g per capita) in Switzerland (2009): 13、Consumption (g per capita、approx.) in Germany (2009): 6.1、exact) in Germany (2009): 6.9、Consumption (g per capita) in the USA (2002): 21、Consumption (g per capita) in France (2004): 55、Excretion rate: 0.037、Calculated removal (%): 75.1、An over-the-counter analgesic (pain reliever) and antipyretic (fever reducer). It is commonly used for the relief of fever、headaches、and other minor aches and pains、and is a major ingredient in numerous cold and flu remedies.、Use Classification: Cosmetics -> Stabilizing、Pharmaceuticals -> Animal Drugs -> Approved in Taiwan、Methods of Manufacturing: p-Nitrophenol is reduced and the resulting p-aminophenol is acetylated by means of heating with a mixture of acetic anhydride and glacial acetic acid. The crude product may be purified by recrystallization from an ethanol-water mixture.、Production is by the acetylation of 4-aminophenol. This can be achieved with acetic acid and acetic anhydride at 80 °C、with acetic anhydride in pyridine at 100 °C、with acetyl chloride and pyridine in toluene at 60 °C、or by the action of ketene in alcoholic suspension. 4-Hydroxyacetanilide also may be synthesized directly from 4-nitrophenol. The available reduction-acetylation systems include tin with acetic acid、hydrogenation over Pd-C in acetic anhydride、and hydrogenation over platinum in acetic acid.、Preparation: ... Wilbert、De Angelis、United States of America patent 2998450 (1961 to Warner-Lambert).、Formulations、Preparations: Table: Acetaminophen Preparations [Table#4343]、Ofirmev: (acetaminophen) injection: 1000 mg、100mL (10 mg、mL)、Common combination products containing acetaminophen include the following: Darvocet、Excedrin ES、Lorcet、Norco、NyQuil、Percocet、Unisom dual relief formula、Sominex 2、tylenol with Codeine、Tylenol PM、Tylox、Vicks formula 44-D、and Vicodin.、Proprietary Preparation: Crocin (India)、Consumption Patterns: PRINCIPALLY USED AS A MEDICINAL (1976).、Acetaminophen. Analgesic、75%、exports、25%.、CHEMICAL PROFILE: Acetaminophen. Demand: 1987: 30 million lb、1988: 30.5 million lb、1992、projected、: 31.5 million lb (Includes exports、but not imports、which totaled about 5 million lb last year.)、U.S. Production: (1975) 4.5X10+9 GRAMS (INCL PHENACETIN)、(1976) GREATER THAN 2.27X10+6 GRAMS、Acetaminophen was one of the most used pharmaceuticals in England during 2002、at an amount used per year of 390、954.26 kg and has been detected in the environment.、Production volumes for non-confidential chemicals reported under the Inventory Update Rule.[Table#4345]、For more U.S. Production (Complete) data for ACETAMINOPHEN (6 total)、U.S. Imports: (1972) 9.1X10+7 GRAMS (PRINCPL CUSTMS DISTS)、(1975) 3.46X10+8 GRAMS (PRINCPL CUSTMS DISTS)、General Manufacturing Information: Acetamide、N-(4-hydroxyphenyl)-: ACTIVE。
对乙酰氨基酚 是一种化工化合物,登记 CAS 号为 103-90-2,分子式 C8H9NO2(分子量 151.16)。
登记 CAS 号:103-90-2
其分子式 C8H9NO2 由 8 个碳、9 个氢、1 个氮、2 个氧 组成。
别名/同义词:对乙酰氨基酚 · Acetaminophen
对乙酰氨基酚 的 CAS 登记号为 103-90-2。
分子式 C8H9NO2,分子量 151.16。
别名/同义词:对乙酰氨基酚、Acetaminophen。
登记用途:Uses: Registered for use in the US for control of brown tree snakes、[NPIRS] Used to make azo dyes、photographic chemicals、and pharmaceuticals、as a stabilizer for hydrogen peroxide、and as a therapeutic analgesic and antipyretic、[HSDB]、Manufacture of azo dyes、photographic chemicals.、Stabilizer for hydrogen peroxide、An analgesic used as an aspirin substitute、Analgesics、Non-Narcotic、Antipyretics、For more Uses (Complete) data for ACETAMINOPHEN (6 total)、please visit the HSDB record page.、Use (kg) in Switzerland (2009): >100000、Use (kg、approx.) in Germany (2009): >500000、exact) in Germany (2009): 564712、Use (kg) in USA (2002): 5790000、Use (kg) in France (2004): 3303077、Consumption (g per capita) in Switzerland (2009): 13、Consumption (g per capita、approx.) in Germany (2009): 6.1、exact) in Germany (2009): 6.9、Consumption (g per capita) in the USA (2002): 21、Consumption (g per capita) in France (2004): 55、Excretion rate: 0.037、Calculated removal (%): 75.1、An over-the-counter analgesic (pain reliever) and antipyretic (fever reducer). It is commonly used for the relief of fever、headaches、and other minor aches and pains、and is a major ingredient in numerous cold and flu remedies.、Use Classification: Cosmetics -> Stabilizing、Pharmaceuticals -> Animal Drugs -> Approved in Taiwan、Methods of Manufacturing: p-Nitrophenol is reduced and the resulting p-aminophenol is acetylated by means of heating with a mixture of acetic anhydride and glacial acetic acid. The crude product may be purified by recrystallization from an ethanol-water mixture.、Production is by the acetylation of 4-aminophenol. This can be achieved with acetic acid and acetic anhydride at 80 °C、with acetic anhydride in pyridine at 100 °C、with acetyl chloride and pyridine in toluene at 60 °C、or by the action of ketene in alcoholic suspension. 4-Hydroxyacetanilide also may be synthesized directly from 4-nitrophenol. The available reduction-acetylation systems include tin with acetic acid、hydrogenation over Pd-C in acetic anhydride、and hydrogenation over platinum in acetic acid.、Preparation: ... Wilbert、De Angelis、United States of America patent 2998450 (1961 to Warner-Lambert).、Formulations、Preparations: Table: Acetaminophen Preparations [Table#4343]、Ofirmev: (acetaminophen) injection: 1000 mg、100mL (10 mg、mL)、Common combination products containing acetaminophen include the following: Darvocet、Excedrin ES、Lorcet、Norco、NyQuil、Percocet、Unisom dual relief formula、Sominex 2、tylenol with Codeine、Tylenol PM、Tylox、Vicks formula 44-D、and Vicodin.、Proprietary Preparation: Crocin (India)、Consumption Patterns: PRINCIPALLY USED AS A MEDICINAL (1976).、Acetaminophen. Analgesic、75%、exports、25%.、CHEMICAL PROFILE: Acetaminophen. Demand: 1987: 30 million lb、1988: 30.5 million lb、1992、projected、: 31.5 million lb (Includes exports、but not imports、which totaled about 5 million lb last year.)、U.S. Production: (1975) 4.5X10+9 GRAMS (INCL PHENACETIN)、(1976) GREATER THAN 2.27X10+6 GRAMS、Acetaminophen was one of the most used pharmaceuticals in England during 2002、at an amount used per year of 390、954.26 kg and has been detected in the environment.、Production volumes for non-confidential chemicals reported under the Inventory Update Rule.[Table#4345]、For more U.S. Production (Complete) data for ACETAMINOPHEN (6 total)、U.S. Imports: (1972) 9.1X10+7 GRAMS (PRINCPL CUSTMS DISTS)、(1975) 3.46X10+8 GRAMS (PRINCPL CUSTMS DISTS)、General Manufacturing Information: Acetamide、N-(4-hydroxyphenyl)-: ACTIVE。
对乙酰氨基酚(CAS 103-90-2)的独立参考数据,整理自公开化学数据库。
| CAS 号 | 103-90-2 |
|---|---|
| PubChem CID | 1983 |
| 分子式 | C8H9NO2 |
| IUPAC 名称 | N-(4-hydroxyphenyl)acetamide |
| UNII(FDA) | 362O9ITL9D |
| Molecular Weight | 151.16 |
|---|---|
| XLogP3 | 0.5 |
| Hydrogen Bond Donor Count | 2 |
| Hydrogen Bond Acceptor Count | 2 |
| Rotatable Bond Count | 1 |
| Exact Mass | 151.063328530 |
| Monoisotopic Mass | 151.063328530 |
| Topological Polar Surface Area | 49.3 |
| Heavy Atom Count | 11 |
| Boiling Point | >500 |
|---|---|
| Boiling Point | >500 °C |
| Melting Point | 336 to 342 °F (NTP, 1992) |
| Melting Point | 168-172 |
| Melting Point | 168 °C |
| Melting Point | MP: 169-170.5 °C |
| Melting Point | 170 °C |
| Melting Point | 169-170 °C |
| Solubility | 1 to 5 mg/mL at 72 °F (NTP, 1992) |
| Solubility | In water, 14,000 mg/L at 25 °C |
acetaminophen; Paracetamol; 4-Acetamidophenol; 103-90-2; N-(4-Hydroxyphenyl)acetamide; Tylenol; APAP; 4'-Hydroxyacetanilide; Datril; Panadol; N-Acetyl-p-aminophenol; Acetaminofen; Algotropyl; p-Acetamidophenol; p-Hydroxyacetanilide; Doliprane
| 法规与食品接触 | CIR / INCI: Stabilizing |
|---|---|
| GHS 通报统计 | 1.2% (5 / 432) |
| GHS 通报统计 | 1.2% (5 / 432) |
|---|---|
| 已通报的危害声明 | H302 (98.1%), H315 (17.4%), H319 (17.1%), H412 (36.8%), H401, H411, H341, H370 |
扑热息痛 · CAS 103-90-2 · C8H9NO2. UNII 362O9ITL9D. Boiling Point: >500; Boiling Point: >500 °C; Melting Point: 336 to 342 °F (NTP, 1992).
数据来源:PubChem / Wikidata;与随货 COA 不一致时以 COA 为准。
English page: Acetaminophen