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对乙酰氨基酚

CAS 103-90-2C8H9NO2MW 151.16

对乙酰氨基酚(CAS 103-90-2):分子式 C8H9NO2、分子量 151.16。

产品概览

CAS号103-90-2
分子式C8H9NO2
分子量151.16
熔点336 to 342 °F (NTP, 1992)
沸点>500
LogP0.5
应用领域Uses: Registered for use in the US for control of brown tree snakes、[NPIRS] Used to make azo dyes、photographic chemicals、and pharmaceuticals、as a stabilizer for hydrogen peroxide、and as a therapeutic analgesic and antipyretic、[HSDB]、Manufacture of azo dyes、photographic chemicals.、Stabilizer for hydrogen peroxide、An analgesic used as an aspirin substitute、Analgesics、Non-Narcotic、Antipyretics、For more Uses (Complete) data for ACETAMINOPHEN (6 total)、please visit the HSDB record page.、Use (kg) in Switzerland (2009): >100000、Use (kg、approx.) in Germany (2009): >500000、exact) in Germany (2009): 564712、Use (kg) in USA (2002): 5790000、Use (kg) in France (2004): 3303077、Consumption (g per capita) in Switzerland (2009): 13、Consumption (g per capita、approx.) in Germany (2009): 6.1、exact) in Germany (2009): 6.9、Consumption (g per capita) in the USA (2002): 21、Consumption (g per capita) in France (2004): 55、Excretion rate: 0.037、Calculated removal (%): 75.1、An over-the-counter analgesic (pain reliever) and antipyretic (fever reducer). It is commonly used for the relief of fever、headaches、and other minor aches and pains、and is a major ingredient in numerous cold and flu remedies.、Use Classification: Cosmetics -> Stabilizing、Pharmaceuticals -> Animal Drugs -> Approved in Taiwan、Methods of Manufacturing: p-Nitrophenol is reduced and the resulting p-aminophenol is acetylated by means of heating with a mixture of acetic anhydride and glacial acetic acid. The crude product may be purified by recrystallization from an ethanol-water mixture.、Production is by the acetylation of 4-aminophenol. This can be achieved with acetic acid and acetic anhydride at 80 °C、with acetic anhydride in pyridine at 100 °C、with acetyl chloride and pyridine in toluene at 60 °C、or by the action of ketene in alcoholic suspension. 4-Hydroxyacetanilide also may be synthesized directly from 4-nitrophenol. The available reduction-acetylation systems include tin with acetic acid、hydrogenation over Pd-C in acetic anhydride、and hydrogenation over platinum in acetic acid.、Preparation: ... Wilbert、De Angelis、United States of America patent 2998450 (1961 to Warner-Lambert).、Formulations、Preparations: Table: Acetaminophen Preparations [Table#4343]、Ofirmev: (acetaminophen) injection: 1000 mg、100mL (10 mg、mL)、Common combination products containing acetaminophen include the following: Darvocet、Excedrin ES、Lorcet、Norco、NyQuil、Percocet、Unisom dual relief formula、Sominex 2、tylenol with Codeine、Tylenol PM、Tylox、Vicks formula 44-D、and Vicodin.、Proprietary Preparation: Crocin (India)、Consumption Patterns: PRINCIPALLY USED AS A MEDICINAL (1976).、Acetaminophen. Analgesic、75%、exports、25%.、CHEMICAL PROFILE: Acetaminophen. Demand: 1987: 30 million lb、1988: 30.5 million lb、1992、projected、: 31.5 million lb (Includes exports、but not imports、which totaled about 5 million lb last year.)、U.S. Production: (1975) 4.5X10+9 GRAMS (INCL PHENACETIN)、(1976) GREATER THAN 2.27X10+6 GRAMS、Acetaminophen was one of the most used pharmaceuticals in England during 2002、at an amount used per year of 390、954.26 kg and has been detected in the environment.、Production volumes for non-confidential chemicals reported under the Inventory Update Rule.[Table#4345]、For more U.S. Production (Complete) data for ACETAMINOPHEN (6 total)、U.S. Imports: (1972) 9.1X10+7 GRAMS (PRINCPL CUSTMS DISTS)、(1975) 3.46X10+8 GRAMS (PRINCPL CUSTMS DISTS)、General Manufacturing Information: Acetamide、N-(4-hydroxyphenyl)-: ACTIVE

应用领域

登记用途:Uses: Registered for use in the US for control of brown tree snakes、[NPIRS] Used to make azo dyes、photographic chemicals、and pharmaceuticals、as a stabilizer for hydrogen peroxide、and as a therapeutic analgesic and antipyretic、[HSDB]、Manufacture of azo dyes、photographic chemicals.、Stabilizer for hydrogen peroxide、An analgesic used as an aspirin substitute、Analgesics、Non-Narcotic、Antipyretics、For more Uses (Complete) data for ACETAMINOPHEN (6 total)、please visit the HSDB record page.、Use (kg) in Switzerland (2009): >100000、Use (kg、approx.) in Germany (2009): >500000、exact) in Germany (2009): 564712、Use (kg) in USA (2002): 5790000、Use (kg) in France (2004): 3303077、Consumption (g per capita) in Switzerland (2009): 13、Consumption (g per capita、approx.) in Germany (2009): 6.1、exact) in Germany (2009): 6.9、Consumption (g per capita) in the USA (2002): 21、Consumption (g per capita) in France (2004): 55、Excretion rate: 0.037、Calculated removal (%): 75.1、An over-the-counter analgesic (pain reliever) and antipyretic (fever reducer). It is commonly used for the relief of fever、headaches、and other minor aches and pains、and is a major ingredient in numerous cold and flu remedies.、Use Classification: Cosmetics -> Stabilizing、Pharmaceuticals -> Animal Drugs -> Approved in Taiwan、Methods of Manufacturing: p-Nitrophenol is reduced and the resulting p-aminophenol is acetylated by means of heating with a mixture of acetic anhydride and glacial acetic acid. The crude product may be purified by recrystallization from an ethanol-water mixture.、Production is by the acetylation of 4-aminophenol. This can be achieved with acetic acid and acetic anhydride at 80 °C、with acetic anhydride in pyridine at 100 °C、with acetyl chloride and pyridine in toluene at 60 °C、or by the action of ketene in alcoholic suspension. 4-Hydroxyacetanilide also may be synthesized directly from 4-nitrophenol. The available reduction-acetylation systems include tin with acetic acid、hydrogenation over Pd-C in acetic anhydride、and hydrogenation over platinum in acetic acid.、Preparation: ... Wilbert、De Angelis、United States of America patent 2998450 (1961 to Warner-Lambert).、Formulations、Preparations: Table: Acetaminophen Preparations [Table#4343]、Ofirmev: (acetaminophen) injection: 1000 mg、100mL (10 mg、mL)、Common combination products containing acetaminophen include the following: Darvocet、Excedrin ES、Lorcet、Norco、NyQuil、Percocet、Unisom dual relief formula、Sominex 2、tylenol with Codeine、Tylenol PM、Tylox、Vicks formula 44-D、and Vicodin.、Proprietary Preparation: Crocin (India)、Consumption Patterns: PRINCIPALLY USED AS A MEDICINAL (1976).、Acetaminophen. Analgesic、75%、exports、25%.、CHEMICAL PROFILE: Acetaminophen. Demand: 1987: 30 million lb、1988: 30.5 million lb、1992、projected、: 31.5 million lb (Includes exports、but not imports、which totaled about 5 million lb last year.)、U.S. Production: (1975) 4.5X10+9 GRAMS (INCL PHENACETIN)、(1976) GREATER THAN 2.27X10+6 GRAMS、Acetaminophen was one of the most used pharmaceuticals in England during 2002、at an amount used per year of 390、954.26 kg and has been detected in the environment.、Production volumes for non-confidential chemicals reported under the Inventory Update Rule.[Table#4345]、For more U.S. Production (Complete) data for ACETAMINOPHEN (6 total)、U.S. Imports: (1972) 9.1X10+7 GRAMS (PRINCPL CUSTMS DISTS)、(1975) 3.46X10+8 GRAMS (PRINCPL CUSTMS DISTS)、General Manufacturing Information: Acetamide、N-(4-hydroxyphenyl)-: ACTIVE。

技术档案

这个产品是什么

对乙酰氨基酚 是一种化工化合物,登记 CAS 号为 103-90-2,分子式 C8H9NO2(分子量 151.16)。

识别信息

登记 CAS 号:103-90-2

其分子式 C8H9NO2 由 8 个碳、9 个氢、1 个氮、2 个氧 组成。

别名/同义词:对乙酰氨基酚 · Acetaminophen

常见问题

对乙酰氨基酚 的 CAS 号是多少?

对乙酰氨基酚 的 CAS 登记号为 103-90-2。

对乙酰氨基酚 的分子式与分子量是多少?

分子式 C8H9NO2,分子量 151.16。

对乙酰氨基酚 还有哪些别名?

别名/同义词:对乙酰氨基酚、Acetaminophen。

对乙酰氨基酚 的登记用途是什么?

登记用途:Uses: Registered for use in the US for control of brown tree snakes、[NPIRS] Used to make azo dyes、photographic chemicals、and pharmaceuticals、as a stabilizer for hydrogen peroxide、and as a therapeutic analgesic and antipyretic、[HSDB]、Manufacture of azo dyes、photographic chemicals.、Stabilizer for hydrogen peroxide、An analgesic used as an aspirin substitute、Analgesics、Non-Narcotic、Antipyretics、For more Uses (Complete) data for ACETAMINOPHEN (6 total)、please visit the HSDB record page.、Use (kg) in Switzerland (2009): >100000、Use (kg、approx.) in Germany (2009): >500000、exact) in Germany (2009): 564712、Use (kg) in USA (2002): 5790000、Use (kg) in France (2004): 3303077、Consumption (g per capita) in Switzerland (2009): 13、Consumption (g per capita、approx.) in Germany (2009): 6.1、exact) in Germany (2009): 6.9、Consumption (g per capita) in the USA (2002): 21、Consumption (g per capita) in France (2004): 55、Excretion rate: 0.037、Calculated removal (%): 75.1、An over-the-counter analgesic (pain reliever) and antipyretic (fever reducer). It is commonly used for the relief of fever、headaches、and other minor aches and pains、and is a major ingredient in numerous cold and flu remedies.、Use Classification: Cosmetics -> Stabilizing、Pharmaceuticals -> Animal Drugs -> Approved in Taiwan、Methods of Manufacturing: p-Nitrophenol is reduced and the resulting p-aminophenol is acetylated by means of heating with a mixture of acetic anhydride and glacial acetic acid. The crude product may be purified by recrystallization from an ethanol-water mixture.、Production is by the acetylation of 4-aminophenol. This can be achieved with acetic acid and acetic anhydride at 80 °C、with acetic anhydride in pyridine at 100 °C、with acetyl chloride and pyridine in toluene at 60 °C、or by the action of ketene in alcoholic suspension. 4-Hydroxyacetanilide also may be synthesized directly from 4-nitrophenol. The available reduction-acetylation systems include tin with acetic acid、hydrogenation over Pd-C in acetic anhydride、and hydrogenation over platinum in acetic acid.、Preparation: ... Wilbert、De Angelis、United States of America patent 2998450 (1961 to Warner-Lambert).、Formulations、Preparations: Table: Acetaminophen Preparations [Table#4343]、Ofirmev: (acetaminophen) injection: 1000 mg、100mL (10 mg、mL)、Common combination products containing acetaminophen include the following: Darvocet、Excedrin ES、Lorcet、Norco、NyQuil、Percocet、Unisom dual relief formula、Sominex 2、tylenol with Codeine、Tylenol PM、Tylox、Vicks formula 44-D、and Vicodin.、Proprietary Preparation: Crocin (India)、Consumption Patterns: PRINCIPALLY USED AS A MEDICINAL (1976).、Acetaminophen. Analgesic、75%、exports、25%.、CHEMICAL PROFILE: Acetaminophen. Demand: 1987: 30 million lb、1988: 30.5 million lb、1992、projected、: 31.5 million lb (Includes exports、but not imports、which totaled about 5 million lb last year.)、U.S. Production: (1975) 4.5X10+9 GRAMS (INCL PHENACETIN)、(1976) GREATER THAN 2.27X10+6 GRAMS、Acetaminophen was one of the most used pharmaceuticals in England during 2002、at an amount used per year of 390、954.26 kg and has been detected in the environment.、Production volumes for non-confidential chemicals reported under the Inventory Update Rule.[Table#4345]、For more U.S. Production (Complete) data for ACETAMINOPHEN (6 total)、U.S. Imports: (1972) 9.1X10+7 GRAMS (PRINCPL CUSTMS DISTS)、(1975) 3.46X10+8 GRAMS (PRINCPL CUSTMS DISTS)、General Manufacturing Information: Acetamide、N-(4-hydroxyphenyl)-: ACTIVE。

PubChem 公开数据

对乙酰氨基酚(CAS 103-90-2)的独立参考数据,整理自公开化学数据库。

各数据库的登记标识

CAS 号103-90-2
PubChem CID1983
分子式C8H9NO2
IUPAC 名称N-(4-hydroxyphenyl)acetamide
UNII(FDA)362O9ITL9D

计算分子描述符

Molecular Weight151.16
XLogP30.5
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count2
Rotatable Bond Count1
Exact Mass151.063328530
Monoisotopic Mass151.063328530
Topological Polar Surface Area49.3
Heavy Atom Count11

在册的理化数值

Boiling Point>500
Boiling Point>500 °C
Melting Point336 to 342 °F (NTP, 1992)
Melting Point168-172
Melting Point168 °C
Melting PointMP: 169-170.5 °C
Melting Point170 °C
Melting Point169-170 °C
Solubility1 to 5 mg/mL at 72 °F (NTP, 1992)
SolubilityIn water, 14,000 mg/L at 25 °C

同义词与商品名

acetaminophen; Paracetamol; 4-Acetamidophenol; 103-90-2; N-(4-Hydroxyphenyl)acetamide; Tylenol; APAP; 4'-Hydroxyacetanilide; Datril; Panadol; N-Acetyl-p-aminophenol; Acetaminofen; Algotropyl; p-Acetamidophenol; p-Hydroxyacetanilide; Doliprane

已收录的法规名录

法规与食品接触CIR / INCI: Stabilizing
GHS 通报统计1.2% (5 / 432)

GHS 危害分类

GHS 通报统计1.2% (5 / 432)
已通报的危害声明H302 (98.1%), H315 (17.4%), H319 (17.1%), H412 (36.8%), H401, H411, H341, H370

公开数据库对它的描述

扑热息痛 · CAS 103-90-2 · C8H9NO2. UNII 362O9ITL9D. Boiling Point: >500; Boiling Point: >500 °C; Melting Point: 336 to 342 °F (NTP, 1992).

数据来源:PubChem / Wikidata;与随货 COA 不一致时以 COA 为准。

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